No renderable structure data available
C1=CC(=CC=C1CCNC(=O)CCl)FChemical Intermediate
Structures, identifiers and computed properties have been matched to the database record by CAS.
| Intermediates | 2-chloro-N-[2-(4-fluorophenyl)ethyl]acetamide |
|---|---|
| IUPAC Name | — |
| CAS Number | 380346-60-1 |
| Database ID | 2384592 |
| Molecular Formula | — |
| Molecular Weight | — |
Product Information
2-chloro-N-[2-(4-fluorophenyl)ethyl]acetamide (CAS 380346-60-1) product identity, structure identifiers and related reaction data for chemical intermediate research and sourcing review.
Potential Applications
For professional research and industrial use only
Database ID 2384592
Safety Notice
For professional research and industrial use only. Review the supplier safety data sheet before handling.
Synthesis data
10 reactions · 10 references
Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-3b8df41a65b44a39bd366ab3dea1dde8Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-3b8df41a65b44a39bd366ab3dea1dde8Conditions: temp:0.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To a solution of 4-fluorophenylethylamine (1.0 equivalent) in dried THF was added Hunig's base (DIEA)(1 equivalent). The mixture was then stirred for 3 minutes at 0° C. Thereafter, a solution of chloroacetylchloride (1.0 equivalent) in THF was added via a syringe over a period of 7 minutes. The reaction mixture was then stirred at room temperature for 1 hour after which time the reaction mixture was condensed in vacuo, quenched with water, extracted with ethyl acetate (3×) and dried over Na2SO4. After concentration in vacuo, compound 1 shown above was obtained, which was carried on further without further purification. LC/MS=M+H 216.1 at 2.18 minutes. The reaction mixture was then stirred at room temperature for 1 hour after which time the reaction mixture condensed in vacuo quenched with water extracted with ethyl acetate (3×) dried over Na2SO4 After concentration in vacuo, compound 1 above was obtained further without further purification LC/MS=M+H 216.1 at 2.18 minutes
Source ID: ord-2336c037773448028dab4503ff9284e9Conditions: temp:0.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To a solution of 4-fluorophenylethylamine (1.0 equivalent) in dried THF was added Hunig's base (DIEA)(1 equivalent). The mixture was then stirred for 3 minutes at 0° C. Thereafter, a solution of chloroacetylchloride (1.0 equivalent) in THF was added via a syringe over a period of 7 minutes. The reaction mixture was then stirred at room temperature for 1 hour after which time the reaction mixture was condensed in vacuo, quenched with water, extracted with ethyl acetate (3×) and dried over Na2SO4. After concentration in vacuo, compound 1 shown above was obtained, which was carried on further without further purification. LC/MS=M+H 216.1 at 2.18 minutes. The reaction mixture was then stirred at room temperature for 1 hour after which time the reaction mixture condensed in vacuo quenched with water extracted with ethyl acetate (3×) dried over Na2SO4 After concentration in vacuo, compound 1 above was obtained further without further purification LC/MS=M+H 216.1 at 2.18 minutes
Source ID: ord-2336c037773448028dab4503ff9284e9Conditions: temp:0.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To a solution of 4-fluorophenylethylamine (1.0 equivalent) in dried THF was added Hunig's base (DIEA) (1 equivalent). The mixture was then stirred for 3 minutes at 0° C. Thereafter, a solution of chloroacetylchloride (1.0 equivalent) in THF was added via a syringe over a period of 7 minutes. The reaction mixture was then stirred at room temperature for 1 hour after which time the reaction mixture was condensed in vacuo, quenched with water, extracted with ethyl acetate (3×) and dried over Na2SO4. After concentration in vacuo, compound 1 shown above was obtained, which was carried on further without further purification. LC/MS=M+H 216.1 at 2.18 minutes. The reaction mixture was then stirred at room temperature for 1 hour after which time the reaction mixture condensed in vacuo quenched with water extracted with ethyl acetate (3×) dried over Na2SO4 After concentration in vacuo, compound 1 above was obtained further without further purification LC/MS=M+H 216.1 at 2.18 minutes
Source ID: ord-38008694e1d74b03ba67e67dbb531d89Conditions: temp:0.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To a solution of 4-fluorophenylethylamine (1.0 equivalent) in dried THF was added Hunig's base (DIEA)(1 equivalent). The mixture was then stirred for 3 minutes at 0° C. Thereafter, a solution of chloroacetylchloride (1.0 equivalent) in THF was added via a syringe over a period of 7 minutes. The reaction mixture was then stirred at room temperature for 1 hour after which time the reaction mixture was condensed in vacuo, quenched with water, extracted with ethyl acetate (3×) and dried over Na2SO4. After concentration in vacuo, compound 1 shown above was obtained, which was carried on further without further purification. LC/MS=M+H 216.1 at 2.18 minutes. The reaction mixture was then stirred at room temperature for 1 hour after which time the reaction mixture condensed in vacuo quenched with water extracted with ethyl acetate (3×) dried over Na2SO4 After concentration in vacuo, compound 1 above was obtained further without further purification LC/MS=M+H 216.1 at 2.18 minutes
Source ID: ord-cbe8f3bffcdc42deb8c1ebb6dc49e7c0Conditions: temp:0.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To a solution of 4-fluorophenylethylamine (1.0 equivalent) in dried THF was added Hunig's base (DIEA)(1 equivalent). The mixture was then stirred for 3 minutes at 0° C. Thereafter, a solution of chloroacetylchloride (1.0 equivalent) in THF was added via a syringe over a period of 7 minutes. The reaction mixture was then stirred at room temperature for 1 hour after which time the reaction mixture was condensed in vacuo, quenched with water, extracted with ethyl acetate (3×) and dried over Na2SO4. After concentration in vacuo, compound 1 shown above was obtained, which was carried on further without further purification. LC/MS=M+H 216.1 at 2.18 minutes. The reaction mixture was then stirred at room temperature for 1 hour after which time the reaction mixture condensed in vacuo quenched with water extracted with ethyl acetate (3×) dried over Na2SO4 After concentration in vacuo, compound 1 above was obtained further without further purification LC/MS=M+H 216.1 at 2.18 minutes
Source ID: ord-cbe8f3bffcdc42deb8c1ebb6dc49e7c0Conditions: temp:0.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To a solution of 4-fluorophenylethylamine (1.0 equivalent) in dried THF was added Hunig's base (DIEA)(1 equivalent). The mixture was then stirred for 3 minutes at 0° C. Thereafter, a solution of chloroacetylchloride (1.0 equivalent) in THF was added via a syringe over a period of 7 minutes. The reaction mixture was then stirred at room temperature for 1 hour after which time the reaction mixture was condensed in vacuo, quenched with water, extracted with ethyl acetate (3×) and dried over Na2SO4. After concentration in vacuo, compound 1 shown above was obtained, which was carried on further without further purification. LC/MS=M+H 216.1 at 2.18 minutes. The reaction mixture was then stirred at room temperature for 1 hour after which time the reaction mixture condensed in vacuo quenched with water extracted with ethyl acetate (3×) dried over Na2SO4 After concentration in vacuo, compound 1 above was obtained further without further purification LC/MS=M+H 216.1 at 2.18 minutes
Source ID: ord-cbe8f3bffcdc42deb8c1ebb6dc49e7c0Conditions: temp:0.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To a solution of 4-fluorophenylethylamine (1.0 equivalent) in dried THF was added Hunig's base (DIEA) (1 equivalent). The mixture was then stirred for 3 minutes at 0° C. Thereafter, a solution of chloroacetylchloride (1.0 equivalent) in THF was added via a syringe over a period of 7 minutes. The reaction mixture was then stirred at room temperature for 1 hour after which time the reaction mixture was condensed in vacuo, quenched with water, extracted with ethyl acetate (3×) and dried over Na2SO4. After concentration in vacuo, compound 1 shown above was obtained, which was carried on further without further purification. LC/MS=M+H 216.1 at 2.18 minutes. The reaction mixture was then stirred at room temperature for 1 hour after which time the reaction mixture condensed in vacuo quenched with water extracted with ethyl acetate (3×) dried over Na2SO4 After concentration in vacuo, compound 1 above was obtained further without further purification LC/MS=M+H 216.1 at 2.18 minutes
Source ID: ord-9a339c9a09714690a742bf95be7468a5Conditions: temp:0.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To a solution of 4-fluorophenylethylamine (1.0 equivalent) in dried THF was added Hunig's base (DIEA)(1 equivalent). The mixture was then stirred for 3 minutes at 0° C. Thereafter, a solution of chloroacetylchloride (1.0 equivalent) in THF was added via a syringe over a period of 7 minutes. The reaction mixture was then stirred at room temperature for 1 hour after which time the reaction mixture was condensed in vacuo, quenched with water, extracted with ethyl acetate (3×) and dried over Na2SO4. After concentration in vacuo, compound 1 shown above was obtained, which was carried on further without further purification. LC/MS=M+H 216.1 at 2.18 minutes. The reaction mixture was then stirred at room temperature for 1 hour after which time the reaction mixture condensed in vacuo quenched with water extracted with ethyl acetate (3×) dried over Na2SO4 After concentration in vacuo, compound 1 above was obtained further without further purification LC/MS=M+H 216.1 at 2.18 minutes
Source ID: ord-722cc4d483ea4b8b9bd6def42665c629PubChem References
These sources are listed in the compound's public database record.
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