No renderable structure data available
CS(=O)(=O)CCCOS(=O)(=O)CChemical Intermediate
Structures, identifiers and computed properties have been matched to the database record by CAS.
| Intermediates | 3-methylsulfonylpropyl methanesulfonate |
|---|---|
| IUPAC Name | — |
| CAS Number | 357913-53-2 |
| Database ID | 10262758 |
| Molecular Formula | — |
| Molecular Weight | — |
Product Information
3-methylsulfonylpropyl methanesulfonate (CAS 357913-53-2) product identity, structure identifiers and related reaction data for chemical intermediate research and sourcing review.
Potential Applications
For professional research and industrial use only
Database ID 10262758
Safety Notice
For professional research and industrial use only. Review the supplier safety data sheet before handling.
Synthesis data
12 reactions · 12 references
Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-b8773db525994ce78d2fa01a461867aeConditions: temp:70.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: Step B To a solution of 3-methoxy-4-nitrophenol (0.5 g, 3 mmol) prepared in Example 132 Step A in anhydrous DMF (25 mL) were added K2CO3 (0.8 g, 5.9 mmol) and methanesulfonic acid 3-methanesulfonyl-propyl ester (0.7 g, 3.2 mmol) sequentially. The reaction mixture was heated at 70° C. for 4 h. The mixture was cooled to room temperature, and diluted with water. The mixture was extracted with ethyl acetate three times. The combined organic extract was washed with water, brine, dried over MgSO4, and concentrated to give 2-methoxy-4-(3-(methylsulfonyl)propoxy)-1-nitrobenzene as a off white solid (0.58 g, 68%). The mixture was cooled to room temperature The mixture was extracted with ethyl acetate three times The combined organic extract was washed with water, brine dried over MgSO4 concentrated
Source ID: ord-847e28c761324cefae5dca718d8fae0bConditions: temp:0.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: Step A To a solution of 3-methanesulfonyl-propan-1-ol (Cambridge) (0.5 g, 3.6 mmol) in dichloromethane (3 mL) at 0° C. was added triethylamine (0.5 g, 5 mmol), and methanesulfonyl chloride (0.3 mL, 4 mmol, Aldrich). The reaction mixture was stirred at 0° C. for 2 h. The mixture was poured into water, extracted with dichloromethane. The organic layer was separated, washed with water, brine, dried over MgSO4, and concentrated to give crude methanesulfonic acid 3-methanesulfonyl-propyl ester as a yellow oil (Yield 0.7 g, 90%). extracted with dichloromethane The organic layer was separated washed with water, brine dried over MgSO4 concentrated
Source ID: ord-f0bbd623ad704d3fb4e1c7c6bfa3c612Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 1-(3-Methanesulfonyl-propyl)-piperazine dihydrochloride was prepared from 1-tert-butyloxycarbonyl-piperazine and methanesulfonic acid 3-methanesulfonyl-propyl ester (prepared according to Baerlocher, F. J. et al. Aust. J. Chem. 1999, 52, 167-172) in an analogous manner as described for the preparation of N-(2-methoxy-1-methyl-ethyl)-2-piperazin-1-yl-acetamide dihydrochloride (example 40).
Source ID: ord-2d00d5a416a84e138dbe3dd3a13d688fConditions: temp:70.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: Step B To a solution of 3-methoxy-4-nitrophenol (0.5 g, 3 mmol) prepared in Example 132 Step A in anhydrous DMF (25 mL) were added K2CO3 (0.8 g, 5.9 mmol) and methanesulfonic acid 3-methanesulfonyl-propyl ester (0.7 g, 3.2 mmol) sequentially. The reaction mixture was heated at 70° C. for 4 h. The mixture was cooled to room temperature, and diluted with water. The mixture was extracted with ethyl acetate three times. The combined organic extract was washed with water, brine, dried over MgSO4, and concentrated to give 2-methoxy-4-(3-(methylsulfonyl)propoxy)-1-nitrobenzene as a off white solid (0.58 g, 68%). The mixture was cooled to room temperature The mixture was extracted with ethyl acetate three times The combined organic extract was washed with water, brine dried over MgSO4 concentrated
Source ID: ord-847e28c761324cefae5dca718d8fae0bConditions: temp:70.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: Step B To a solution of 3-methoxy-4-nitrophenol (0.5 g, 3 mmol) prepared in Example 132 Step A in anhydrous DMF (25 mL) were added K2CO3 (0.8 g, 5.9 mmol) and methanesulfonic acid 3-methanesulfonyl-propyl ester (0.7 g, 3.2 mmol) sequentially. The reaction mixture was heated at 70° C. for 4 h. The mixture was cooled to room temperature, and diluted with water. The mixture was extracted with ethyl acetate three times. The combined organic extract was washed with water, brine, dried over MgSO4, and concentrated to give 2-methoxy-4-(3-(methylsulfonyl)propoxy)-1-nitrobenzene as a off white solid (0.58 g, 68%). The mixture was cooled to room temperature The mixture was extracted with ethyl acetate three times The combined organic extract was washed with water, brine dried over MgSO4 concentrated
Source ID: ord-847e28c761324cefae5dca718d8fae0bConditions: temp:0.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: Step A To a solution of 3-methanesulfonyl-propan-1-ol (Cambridge) (0.5 g, 3.6 mmol) in dichloromethane (3 mL) at 0° C. was added triethylamine (0.5 g, 5 mmol), and methanesulfonyl chloride (0.3 mL, 4 mmol, Aldrich). The reaction mixture was stirred at 0° C. for 2 h. The mixture was poured into water, extracted with dichloromethane. The organic layer was separated, washed with water, brine, dried over MgSO4, and concentrated to give crude methanesulfonic acid 3-methanesulfonyl-propyl ester as a yellow oil (Yield 0.7 g, 90%). extracted with dichloromethane The organic layer was separated washed with water, brine dried over MgSO4 concentrated
Source ID: ord-f0bbd623ad704d3fb4e1c7c6bfa3c612Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-b8773db525994ce78d2fa01a461867aeConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: The title compound was prepared from 1-tert-butyloxycarbonyl-piperazine and methanesulfonic acid 3-methanesulfonyl-propyl ester (prepared according to Baerlocher, F. J. et al. Aust. J. Chem. 1999, 52, 167-172) in an analogous manner as described in example 21.
Source ID: ord-e89528e1153b4018ab2e50b6865cba63Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 1-(3-Methanesulfonyl-propyl)-piperazine dihydrochloride was prepared from 1-tert-butyloxycarbonyl-piperazine and methanesulfonic acid 3-methanesulfonyl-propyl ester (prepared according to Baerlocher, F. J. et al. Aust. J. Chem. 1999, 52, 167-172) in an analogous manner as described for the preparation of N-(2-methoxy-1-methyl-ethyl)-2-piperazin-1-yl-acetamide dihydrochloride (example 40).
Source ID: ord-2d00d5a416a84e138dbe3dd3a13d688fConditions: temp:70.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: Step B To a solution of 3-methoxy-4-nitrophenol (0.5 g, 3 mmol) prepared in Example 132 Step A in anhydrous DMF (25 mL) were added K2CO3 (0.8 g, 5.9 mmol) and methanesulfonic acid 3-methanesulfonyl-propyl ester (0.7 g, 3.2 mmol) sequentially. The reaction mixture was heated at 70° C. for 4 h. The mixture was cooled to room temperature, and diluted with water. The mixture was extracted with ethyl acetate three times. The combined organic extract was washed with water, brine, dried over MgSO4, and concentrated to give 2-methoxy-4-(3-(methylsulfonyl)propoxy)-1-nitrobenzene as a off white solid (0.58 g, 68%). The mixture was cooled to room temperature The mixture was extracted with ethyl acetate three times The combined organic extract was washed with water, brine dried over MgSO4 concentrated
Source ID: ord-847e28c761324cefae5dca718d8fae0bConditions: temp:0.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: Step A To a solution of 3-methanesulfonyl-propan-1-ol (Cambridge) (0.5 g, 3.6 mmol) in dichloromethane (3 mL) at 0° C. was added triethylamine (0.5 g, 5 mmol), and methanesulfonyl chloride (0.3 mL, 4 mmol, Aldrich). The reaction mixture was stirred at 0° C. for 2 h. The mixture was poured into water, extracted with dichloromethane. The organic layer was separated, washed with water, brine, dried over MgSO4, and concentrated to give crude methanesulfonic acid 3-methanesulfonyl-propyl ester as a yellow oil (Yield 0.7 g, 90%). extracted with dichloromethane The organic layer was separated washed with water, brine dried over MgSO4 concentrated
Source ID: ord-f0bbd623ad704d3fb4e1c7c6bfa3c612PubChem References
These sources are listed in the compound's public database record.
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