355423-48-2

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: To 97C (2.0 g, 10 mmol) in acetone (30 mL) was added K2CO3 (4.1 g) and iodoethane (2.4 mL). The mixture was stirred at rt overnight. After TLC (10% EtOAc/Hexane) indicated the reaction was complete, the mixture was diluted with diethyl ether, washed with water and brine. The organic layer was dried over MgSO4 and concentrated to give 97D as an colorless oil (1.7 g, 72% yield). 1H NMR (400 MHz, CDCl3) δ ppm 1.44 (t, J=7.03 Hz, 3H) 4.07 (q, J=7.03 Hz, 2H) 6.94 (dd, J=10.77, 8.13 Hz, 1H) 7.11 (dd, J=8.35, 6.59 Hz, 1H). washed with water and brine The organic layer was dried over MgSO4 concentrated