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CC(C(=O)C1=CC=C(C=C1)F)BrChemical Intermediate
Structures, identifiers and computed properties have been matched to the database record by CAS.
| Intermediates | 2-bromo-1-(4-fluorophenyl)propan-1-one |
|---|---|
| IUPAC Name | — |
| CAS Number | 345-94-8 |
| Database ID | 13051652 |
| Molecular Formula | — |
| Molecular Weight | — |
Product Information
2-bromo-1-(4-fluorophenyl)propan-1-one (CAS 345-94-8) product identity, structure identifiers and related reaction data for chemical intermediate research and sourcing review.
Potential Applications
For professional research and industrial use only
Database ID 13051652
Safety Notice
For professional research and industrial use only. Review the supplier safety data sheet before handling.
Synthesis data
9 reactions · 9 references
Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-dd5f56c418384014b0daa50ff5c201e6Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: The reaction is performed under the conditions of Example 4a, starting with 9.24 g (0.04 mole) of 2-bromo-1-(4-fluorophenyl)-1-propanone, 10.05 g (0.04 mole) of 2-(4-fluorophenyl)-2-(4-piperidyl)1,3-dioxolane and 5.56 g of potassium carbonate in 150 ml of acetonitrile.
Source ID: ord-8b283410461c45ed90d138e288973eb1Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: In anhydrous ethanol (10 ml) was dissolved 3-amino-3-morpholinoacrylonitrile, as prepared from ethyl 2-cyano-acetimidate (1.0 g) and morpholine (0.78 g) as in Reference Example 3, followed by addition of sodium hydrogen carbonate (0.95 g). Then, a solution of 2-bromo-4'-fluoropropiophenone (2.06 g) in ethanol was added dropwise thereto at room temperature with stirring. The mixture was refluxed for 10 minutes and, then, stirred at room temperature overnight. The separated crystal crop was collected by filtration and recrystallized from ethanol to provide the title compound as colorless crystals (0.12 g). m.p. 245-247° C. The mixture was refluxed for 10 minutes stirred at room temperature overnight The separated crystal crop was collected by filtration recrystallized from ethanol
Source ID: ord-26083fae6cec4dfd85d3186086ac8543Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: In anhydrous ethanol (10 ml) was dissolved 3-amino-3-morpholinoacrylonitrile, as prepared from ethyl 2-cyano-acetimidate (1.0 g) and morpholine (0.78 g) as in Reference Example 3, followed by addition of sodium hydrogen carbonate (0.95 g). Then, a solution of 2-bromo-4′-fluoropropiophenone (2.06 g) in ethanol was added dropwise thereto at room temperature with stirring. The mixture was refluxed for 10 minutes and, then, stirred at room temperature overnight. The separated crystal crop was collected by filtration and recrystallized from ethanol to provide the title compound as colorless crystals (0.12 g). m.p. 245-247° C. The mixture was refluxed for 10 minutes stirred at room temperature overnight The separated crystal crop was collected by filtration recrystallized from ethanol
Source ID: ord-5d75846c7ee841dbba65f3b2e16abd9aConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: In anhydrous ethanol (10 ml) was dissolved 3-amino-3-morpholinoacrylonitrile, as prepared from ethyl 2-cyano-acetimidate (1.0 g) and morpholine (0.78 g) as in Reference Example 3, followed by addition of sodium hydrogen carbonate (0.95 g). Then, a solution of 2-bromo-4′-fluoropropiophenone (2.06 g) in ethanol was added dropwise thereto at room temperature with stirring. The mixture was refluxed for 10 minutes and, then, stirred at room temperature overnight. The separated crystal crop was collected by filtration and recrystallized from ethanol to provide the title compound as colorless crystals (0.12 g). m.p. 245-247° C. The mixture was refluxed for 10 minutes stirred at room temperature overnight The separated crystal crop was collected by filtration recrystallized from ethanol
Source ID: ord-5d75846c7ee841dbba65f3b2e16abd9aConditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-dd5f56c418384014b0daa50ff5c201e6Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: The reaction is performed under the conditions of Example 4a, starting with 9.24 g (0.04 mole) of 2-bromo-1-(4-fluorophenyl)-1-propanone, 10.05 g (0.04 mole) of 2-(4-fluorophenyl)-2-(4-piperidyl)1,3-dioxolane and 5.56 g of potassium carbonate in 150 ml of acetonitrile.
Source ID: ord-8b283410461c45ed90d138e288973eb1Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: In anhydrous ethanol (10 ml) was dissolved 3-amino-3-morpholinoacrylonitrile, as prepared from ethyl 2-cyano-acetimidate (1.0 g) and morpholine (0.78 g) as in Reference Example 3, followed by addition of sodium hydrogen carbonate (0.95 g). Then, a solution of 2-bromo-4'-fluoropropiophenone (2.06 g) in ethanol was added dropwise thereto at room temperature with stirring. The mixture was refluxed for 10 minutes and, then, stirred at room temperature overnight. The separated crystal crop was collected by filtration and recrystallized from ethanol to provide the title compound as colorless crystals (0.12 g). m.p. 245-247° C. The mixture was refluxed for 10 minutes stirred at room temperature overnight The separated crystal crop was collected by filtration recrystallized from ethanol
Source ID: ord-26083fae6cec4dfd85d3186086ac8543Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: In anhydrous ethanol (10 ml) was dissolved 3-amino-3-morpholinoacrylonitrile, as prepared from ethyl 2-cyano-acetimidate (1.0 g) and morpholine (0.78 g) as in Reference Example 3, followed by addition of sodium hydrogen carbonate (0.95 g). Then, a solution of 2-bromo-4′-fluoropropiophenone (2.06 g) in ethanol was added dropwise thereto at room temperature with stirring. The mixture was refluxed for 10 minutes and, then, stirred at room temperature overnight. The separated crystal crop was collected by filtration and recrystallized from ethanol to provide the title compound as colorless crystals (0.12 g). m.p. 245-247° C. The mixture was refluxed for 10 minutes stirred at room temperature overnight The separated crystal crop was collected by filtration recrystallized from ethanol
Source ID: ord-5d75846c7ee841dbba65f3b2e16abd9aPubChem References
These sources are listed in the compound's public database record.
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