No renderable structure data available
B(C1=CC=CC=C1C(=O)OC(C)C)(O)OChemical Intermediate
Structures, identifiers and computed properties have been matched to the database record by CAS.
| Intermediates | 2-(Isopropoxycarbonyl)phenylboronic acid |
|---|---|
| IUPAC Name | — |
| CAS Number | 339538-60-2 |
| Database ID | 53435142 |
| Molecular Formula | — |
| Molecular Weight | — |
Product Information
2-(Isopropoxycarbonyl)phenylboronic acid (CAS 339538-60-2) product identity, structure identifiers and related reaction data for chemical intermediate research and sourcing review.
Potential Applications
For professional research and industrial use only
Database ID 53435142
Safety Notice
For professional research and industrial use only. Review the supplier safety data sheet before handling.
Synthesis data
9 reactions · 9 references
Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-06db46463df34a549caf9abc3aa1e02fConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 2-(Isopropylcarboxy)-phenylboronic acid (S. Caron and J. M. Hawkins, J. Org. Chem. 1998, 63, 2054-2055) (2.2 g, 10.6 mmol) and 2-chloro-5-trifluoromethylpyridine (500 mg, 2.75 mmol) were dissolved in toluene. Tetrakis(triphenylphosphine)palladium (160 mg, 0.14 mmol) was added and the reaction vessel purged by alternating vacuum and nitrogen gas three times. 8 ml of a 10% sodium carbonate solution was added and the reaction mixture was heated at reflux for 1.5 h. The resulting mixture was extracted with ethyl acetate, the combined organic layers dried (magnesium sulfate), filtered and concentrated under vacuum. Purification of the residue by column chromatography eluting with 10% ethyl acetate in hexanes provided the title compound in approximately 70% yield. the reaction vessel purged 8 ml of a 10% sodium carbonate solution was added the reaction mixture was heated at reflux for 1.5 h The resulting mixture was extracted with ethyl acetate the combined organic layers dried (magnesium sulfate) filtered concentrated under vacuum Purification of the residue by column chromatography eluting with 10% ethyl acetate in hexanes
Source ID: ord-8bb323db14634dfba0d4059e3722cebeConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 2-(Isopropylcarboxy)-phenylboronic acid (S. Caron and J. M. Hawkins, J. Org. Chem. 1998, 63, 2054-2055) (2.2 g, 10.6 mmol) and 2-chloro-5-trifluoromethylpyridine (500 mg, 2.75 mmol) were dissolved in toluene. Tetrakis(triphenylphosphine)palladium (160 mg, 0.14 mmol) was added and the reaction vessel purged by alternating vacuum and nitrogen gas three times. 8 ml of a 10% sodium carbonate solution was added and the reaction mixture was heated at reflux for 1.5 h. The resulting mixture was extracted with ethyl acetate, the combined organic layers dried (magnesium sulfate), filtered and concentrated under vacuum. Purification of the residue by column chromatography eluting with 10% ethyl acetate in hexanes provided the title compound in approximately 70% yield. the reaction vessel purged 8 ml of a 10% sodium carbonate solution was added the reaction mixture was heated at reflux for 1.5 h The resulting mixture was extracted with ethyl acetate the combined organic layers dried (magnesium sulfate) filtered concentrated under vacuum Purification of the residue by column chromatography eluting with 10% ethyl acetate in hexanes
Source ID: ord-8bb323db14634dfba0d4059e3722cebeConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 2-(Isopropylcarboxy)-phenylboronic acid (S. Caron and J. M. Hawkins, J. Org. Chem. 1998, 63, 2054-2055) (2.2 g, 10.6 mmol) and 2-chloro-5-trifluoromethylpyridine (500 mg, 2.75 mmol) were dissolved in toluene. Tetrakis(triphenylphosphine)palladium (160 mg, 0.14 mmol) was added and the reaction vessel purged by alternating vacuum and nitrogen gas three times. 8 ml of a 10% sodium carbonate solution was added and the reaction mixture was heated at reflux for 1.5 h. The resulting mixture was extracted with ethyl acetate, the combined organic layers dried (magnesium sulfate), filtered and concentrated under vacuum. Purification of the residue by column chromatography eluting with 10% ethyl acetate in hexanes provided the title compound in approximately 70% yield. the reaction vessel purged 8 ml of a 10% sodium carbonate solution was added the reaction mixture was heated at reflux for 1.5 h The resulting mixture was extracted with ethyl acetate the combined organic layers dried (magnesium sulfate) filtered concentrated under vacuum Purification of the residue by column chromatography eluting with 10% ethyl acetate in hexanes
Source ID: ord-3da357480ed243f08b79952da60fad6eConditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-06db46463df34a549caf9abc3aa1e02fConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 2-(Isopropylcarboxy)-phenylboronic acid (S. Caron and J. M. Hawkins, J. Org. Chem. 1998, 63, 2054-2055) (2.2 g, 10.6 mmol) and 2-chloro-5-trifluoromethylpyridine (500 mg, 2.75 mmol) were dissolved in toluene. Tetrakis(triphenylphosphine)palladium (160 mg, 0.14 mmol) was added and the reaction vessel purged by alternating vacuum and nitrogen gas three times. 8 ml of a 10% sodium carbonate solution was added and the reaction mixture was heated at reflux for 1.5 h. The resulting mixture was extracted with ethyl acetate, the combined organic layers dried (magnesium sulfate), filtered and concentrated under vacuum. Purification of the residue by column chromatography eluting with 10% ethyl acetate in hexanes provided the title compound in approximately 70% yield. the reaction vessel purged 8 ml of a 10% sodium carbonate solution was added the reaction mixture was heated at reflux for 1.5 h The resulting mixture was extracted with ethyl acetate the combined organic layers dried (magnesium sulfate) filtered concentrated under vacuum Purification of the residue by column chromatography eluting with 10% ethyl acetate in hexanes
Source ID: ord-3da357480ed243f08b79952da60fad6eConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 2-(Isopropylcarboxy)-phenylboronic acid (S. Caron and J. M. Hawkins, J. Org. Chem. 1998, 63, 2054-2055) (2.2 g, 10.6 mmol) and 2-chloro-5-trifluoromethylpyridine (500 mg, 2.75 mmol) were dissolved in toluene. Tetrakis(triphenylphosphine)palladium (160 mg, 0.14 mmol) was added and the reaction vessel purged by alternating vacuum and nitrogen gas three times. 8 ml of a 10% sodium carbonate solution was added and the reaction mixture was heated at reflux for 1.5 h. The resulting mixture was extracted with ethyl acetate, the combined organic layers dried (magnesium sulfate), filtered and concentrated under vacuum. Purification of the residue by column chromatography eluting with 10% ethyl acetate in hexanes provided the title compound in approximately 70% yield. the reaction vessel purged 8 ml of a 10% sodium carbonate solution was added the reaction mixture was heated at reflux for 1.5 h The resulting mixture was extracted with ethyl acetate the combined organic layers dried (magnesium sulfate) filtered concentrated under vacuum Purification of the residue by column chromatography eluting with 10% ethyl acetate in hexanes
Source ID: ord-8bb323db14634dfba0d4059e3722cebeConditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-06db46463df34a549caf9abc3aa1e02fConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 2-(Isopropylcarboxy)-phenylboronic acid (S. Caron and J. M. Hawkins, J. Org. Chem. 1998, 63, 2054-2055) (2.2 g, 10.6 mmol) and 2-chloro-5-trifluoromethylpyridine (500 mg, 2.75 mmol) were dissolved in toluene. Tetrakis(triphenylphosphine)palladium (160 mg, 0.14 mmol) was added and the reaction vessel purged by alternating vacuum and nitrogen gas three times. 8 ml of a 10% sodium carbonate solution was added and the reaction mixture was heated at reflux for 1.5 h. The resulting mixture was extracted with ethyl acetate, the combined organic layers dried (magnesium sulfate), filtered and concentrated under vacuum. Purification of the residue by column chromatography eluting with 10% ethyl acetate in hexanes provided the title compound in approximately 70% yield. the reaction vessel purged 8 ml of a 10% sodium carbonate solution was added the reaction mixture was heated at reflux for 1.5 h The resulting mixture was extracted with ethyl acetate the combined organic layers dried (magnesium sulfate) filtered concentrated under vacuum Purification of the residue by column chromatography eluting with 10% ethyl acetate in hexanes
Source ID: ord-3da357480ed243f08b79952da60fad6ePubChem References
These sources are listed in the compound's public database record.
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