butyl 2-(4-aminopiperidin-1-yl)acetate

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: A solution of hydrogen chloride in isopropanol (6 ml) was added to 1.35 g of n-butyl 4-tert-butoxycarbonylamino-1-piperidineacetate, and the mixture was stirred at room temperature for 15 minutes. The solvent was evaporated, and the residue was added with 5 ml of tetrahydrofuran and 1.3 ml of triethylamine. The precipitated solid was filtered off, and the solvent of the filtrate was evaporated to obtain 1.04 g of colorless oil. The solvent was evaporated the residue was added with 5 ml of tetrahydrofuran and 1.3 ml of triethylamine The precipitated solid was filtered off the solvent of the filtrate was evaporated

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: A solution of hydrogen chloride in isopropanol (6 ml) was added to 1.35 g of n-butyl 4-tert-butoxycarbonylamino-1-piperidineacetate, and the mixture was stirred at room temperature for 15 minutes. The solvent was evaporated, and the residue was added with 5 ml of tetrahydrofuran and 1.3 ml of triethylamine. The precipitated solid was filtered off, and the solvent of the filtrate was evaporated to obtain 1.04 g of colorless oil. The solvent was evaporated the residue was added with 5 ml of tetrahydrofuran and 1.3 ml of triethylamine The precipitated solid was filtered off the solvent of the filtrate was evaporated