7-bromo-6-fluoro-1-benzofuran

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: Beginning with 12.7 gm (59 mMol) 6-fluoro-7-bromobenzofuran and 13.2 gm (65 mMol) 1-benzyl-3-methyl-4-oxopiperidine, 18 gm of the desired compound was prepared as an orange oil essentially as described in EXAMPLE 19.

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: Beginning with 5.22 gm (24.3 mMol) 6-fluoro-7-bromobenzofuran and 5.19 gm (25.5 mMol) 1-benzyl-3-methyl-4-oxopiperidine, 4.89 gm (59%) of the desired compound were prepared as a mixture of cis- and trans-isomers, essentially as described in EXAMPLE 3.