No renderable structure data available
C1=CC=C(C(=C1)CC#N)ClChemical Intermediate
Structures, identifiers and computed properties have been matched to the database record by CAS.
| Intermediates | 2-(2-chlorophenyl)acetonitrile |
|---|---|
| IUPAC Name | — |
| CAS Number | 2856-63-5 |
| Database ID | 76112 |
| Molecular Formula | — |
| Molecular Weight | — |
Product Information
2-(2-chlorophenyl)acetonitrile (CAS 2856-63-5) product identity, structure identifiers and related reaction data for chemical intermediate research and sourcing review.
Potential Applications
For professional research and industrial use only
Database ID 76112
Safety Notice
For professional research and industrial use only. Review the supplier safety data sheet before handling.
Synthesis data
12 reactions · 12 references
Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-ff1203a825c04729a3438245ab978288Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-7a8125aff77c43b591fcf863d04acdecConditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-a6b5c682f25c4f1c9c5929309c70f4ddConditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-9ea905a3c3a64b3a91486f82a65f9002Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: An oven dried resealable Schlenk tube was evacuated and backfilled with argon and charged with palladium acetate (2.2 mg, 0.01 mmol, 1.0 mol %), 2-(di-tert-butylphosphino)biphenyl (6.0 mg, 0.020 mmol, 2.0 mol %), phenylboron dihydroxide (183 mg. 1.5 mmol), and potassium fluoride (174 mg, 3.0 mmol). The tube was evacuated and backfilled with argon, and THF (1 mL) and 2-chlorobenzyl cyanide (152 mg, 1.0 mmol) were added through a rubber septum. The tube was sealed with a teflon screwcap, and the reaction mixture was stirred at room temperature until the starting aryl chloride had been completely consumed as judged by GC analysis. The reaction mixture was then diluted with ether (30 mL) and poured into a separatory funnel. The mixture was washed with 1.0 M NaOH (20 mL), and the aqueous layer was extracted with ether (20 mL). The combined organic layers were washed with brine (20 mL), dried over anhydrous magnesium sulfate, filtered, and concentrated. The crude material was purified by flash chromatography on silica gel to afford 178 mg (92%) of the title compound. An oven dried resealable Schlenk tube was evacuated The tube was evacuated were added through a rubber septum had been completely consumed The reaction mixture was then diluted with ether (30 mL) poured into a separatory funnel The mixture was washed with 1.0 M NaOH (20 mL) the aqueous layer was extracted with ether (20 mL) The combined organic layers were washed with brine (20 mL) dried over anhydrous magnesium sulfate filtered concentrated The crude material was purified by flash chromatography on silica gel
Source ID: ord-70312105dcc04818b1d5a943b306a257Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-ff1203a825c04729a3438245ab978288Conditions: temp:0.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To a solution of 2-chloro-phenyl-acetonitrile (15.0 g, 99.0 mmol) in the dichloromethane (50 mL) and H2SO4 (40 mL) is slowly added a mixture of H2SO4 (14 mL) and HNO3 (5.5 mL) at 0° C. The reaction mixture is stirred at 0° C. for 20 minutes, warmed to room temperature for 30 minutes and then concentrated to remove organic solvent. The solution is poured into a beaker containing ice-water (400 mL) to give a crystalline precipitate, which is collected by vacuum filtration and washed with water to give the title intermediate (13.4 g, 69.0%). warmed to room temperature for 30 minutes concentrated to remove organic solvent The solution is poured into a beaker containing ice-water (400 mL) to give a crystalline precipitate, which is collected by vacuum filtration washed with water
Source ID: ord-ded8d23858084359b46e86f8f1efb434Conditions: temp:75.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: Sodium hydride (60% dispersion in mineral oil, 1.28 g, 45 mmol) was suspended in DMF (20 mL) and cooled in an ice bath under a nitrogen atmosphere. (2-Chloro-phenyl)-acetonitrile (1.77 g, 11.7 mmol) in DMF (5 mL) was added slowly, and the mixture stirred for 2 hours. Bis-(2-chloro-ethyl)-carbamic acid tert-butyl ester (3.3 g, 11.1 mmol) in DMF (5 mL) was then added and the mixture heated to 75° C. for 6 hours. The solvent was removed by evaporation under vacuum and the residue dissolved in ethyl acetate (50 mL), washed with water, then brine, dried over magnesium sulphate, filtered and the solvent removed by evaporation under vacuum. The residue was purified by silica chromatography eluting with a mixture of ethyl acetate and hexane. The fractions containing the desired products were combined and the solvent removed by evaporation to give the title compound as an orange gum (1.1 g). LCMS m/z 321.0 [M+H]+. R.T.=4.76 min (Analytical Method 4). cooled in an ice bath under a nitrogen atmosphere The solvent was removed by evaporation under vacuum the residue dissolved in ethyl acetate (50 mL) washed with water brine, dried over magnesium sulphate filtered the solvent removed by evaporation under vacuum The residue was purified by silica chromatography eluting with a mixture of ethyl acetate and hexane The fractions containing the desired products the solvent removed by evaporation
Source ID: ord-6dfa5d3e38844f079e39111db87f1805Conditions: temp:0.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 4-Bromoaniline (6.4 g, 37 mmol) was placed into a three-neck reactor, and the reactor was flushed with argon for 20 min. 60 mL anhydrous toluene was added. After cooling to 0° C., trimethylaluminum (28 mL, 2.0M solution in toluene, 56 mmol) was added slowly to keep the inner temperature below 20° C. Over 0.5 h, the addition was completed. Ice bath was removed, and the reaction mixture was warmed to room temperature and then stirred for additional 2.5 hrs. A solution of 2-chlorobenzyl cyanide (8.4 g, 55 mmol) in 35 mL anhydrous toluene was added, and the reaction mixture was heated to 80° C. After 18 hrs, the reaction mixture was cooled to room temperature and poured over a slurry of silica gel in CHCl3/MeOH (4/1, 400 mL). After stirring for 30 min, the mixture was filtered and the residue was washed with a mixture of CHCl3/MeOH (4/1). The combined filtrates were concentrated in vacuo, and the resulting solid was washed with hexane to give a light pink solid (5.78 g, 48% yield). the reactor was flushed with argon for 20 min 60 mL anhydrous toluene was added the inner temperature below 20° C the addition Ice bath was removed the reaction mixture was warmed to room temperature the reaction mixture was heated to 80° C After 18 hrs the reaction mixture was cooled to room temperature After stirring for 30 min the mixture was filtered the residue was washed with a mixture of CHCl3/MeOH (4/1) The combined filtrates were concentrated in vacuo the resulting solid was washed with hexane
Source ID: ord-f5ec7e642343404b86726cd26ec977bcConditions: temp:0.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 4-Bromoaniline (6.4 g, 37 mmol) was placed into a three-neck reactor, and the reactor was flushed with argon for 20 min. 60 mL anhydrous toluene was added. After cooling to 0° C., trimethylaluminum (28 mL, 2.0M solution in toluene, 56 mmol) was added slowly to keep the inner temperature below 20° C. Over 0.5 h, the addition was completed. Ice bath was removed, and the reaction mixture was warmed to room temperature and then stirred for additional 2.5 hrs. A solution of 2-chlorobenzyl cyanide (8.4 g, 55 mmol) in 35 mL anhydrous toluene was added, and the reaction mixture was heated to 80° C. After 18 hrs, the reaction mixture was cooled to room temperature and poured over a slurry of silica gel in CHCl3/MeOH (4/1, 400 mL). After stirring for 30 min, the mixture was filtered and the residue was washed with a mixture of CHCl3/MeOH (4/1). The combined filtrates were concentrated in vacuo, and the resulting solid was washed with hexane to give a light pink solid (5.78 g, 48% yield). the reactor was flushed with argon for 20 min 60 mL anhydrous toluene was added the inner temperature below 20° C the addition Ice bath was removed the reaction mixture was warmed to room temperature the reaction mixture was heated to 80° C After 18 hrs the reaction mixture was cooled to room temperature After stirring for 30 min the mixture was filtered the residue was washed with a mixture of CHCl3/MeOH (4/1) The combined filtrates were concentrated in vacuo the resulting solid was washed with hexane
Source ID: ord-f5ec7e642343404b86726cd26ec977bcConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A solution of bis(2-chloroethyl)-N-(1,1-dimethylethoxy)carbonyl amine (9.298 g, 38.4 mmol) and 2-chlorophenylacetonitrile (5.0 g, 32.0 mmol) in a 4:1 mixture of THF/DMF (15 mL) was treated with NaH (2.82 g, 70.4 mmol) at 60 OC (7 d). The solvent was removed in vacuo, the residue dissolved in EtOAc (200 ml) and washed with saturated NaHCO3 (50 ml), H2O (2×50ml), and saturated aqueous NaCl (50 ml), dried Na2SO4) and concentrated in vacuo. Trituration of the residue with 100% MeOH afforded 4-(2-chlorophenyl)4-cyano-N-(1,1-dimethylethoxy) carbonyl piperidine as a white solid. The solvent was removed in vacuo the residue dissolved in EtOAc (200 ml) washed with saturated NaHCO3 (50 ml), H2O (2×50ml), and saturated aqueous NaCl (50 ml), dried Na2SO4) and concentrated in vacuo
Source ID: ord-2880c4deeefb4fa4949f94178e64470eConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: An oven dried resealable Schlenk tube was evacuated and backfilled with argon and charged with palladium acetate (2.2 mg, 0.01 mmol, 1.0 mol %), 2-(di-tert-butylphosphino)biphenyl (6.0 mg, 0.020 mmol, 2.0 mol %), phenylboron dihydroxide (183 mg, 1.5 mmol), and potassium fluoride (174 mg, 3.0 mmol). The tube was evacuated and backfilled with argon, and THF (1 mL) and 2-chlorobenzyl cyanide (152 mg, 1.0 mmol) were added through a rubber septum. The tube was sealed with a teflon screwcap, and the reaction mixture was stirred at room temperature until the starting aryl chloride had been completely consumed as judged by GC analysis. The reaction mixture was then diluted with ether (30 mL) and poured into a separatory funnel. The mixture was washed with 1.0 M NaOH (20 mL), and the aqueous layer was extracted with ether (20 mL). The combined organic layers were washed with brine (20 mL), dried over anhydrous magnesium sulfate, filtered, and concentrated. The crude material was purified by flash chromatography on silica gel to afford 178 mg (92%) of the title compound. An oven dried resealable Schlenk tube was evacuated The tube was evacuated were added through a rubber septum had been completely consumed The reaction mixture was then diluted with ether (30 mL) poured into a separatory funnel The mixture was washed with 1.0 M NaOH (20 mL) the aqueous layer was extracted with ether (20 mL) The combined organic layers were washed with brine (20 mL) dried over anhydrous magnesium sulfate filtered concentrated The crude material was purified by flash chromatography on silica gel
Source ID: ord-119d7ae54caf4930861189cb15940807PubChem References
These sources are listed in the compound's public database record.
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