(1R,2R)-2-(methylamino)-2,3-dihydro-1H-inden-1-ol

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: To a solution of trans-2-methylamino-1-indanol (4.9 g, 0.03 m) in 100 ml of ethanol was added 2.8 g (0.033 m) of diketene. After stirring about 1 hour the mixture was concentrated to dryness in vacuo. The residue was dissolved in acetonitrile and the solvent was evaporated in vacuo to 6.3 g (85%) of an oily residue which was used directly in the next step. was concentrated to dryness in vacuo The residue was dissolved in acetonitrile the solvent was evaporated in vacuo to 6.3 g (85%) of an oily residue which