2-bromo-2-methyl-N-phenylpropanamide

Conditions: temp:0.00; pressure:0.00; stir:

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: A neat mixture of AlCl3 (8.28 g) and the amide obtained in Step 1. above (5 g) is heated slowly to about 135°-140° C. and maintained at this temperature for about 10-15 min. Ice water is added slowly to the reaction mixture and the residue is extracted with ether. The organic extract is washed with 1N HCl, 10% aqueous sodium carbonate, dried, filtered and evaporated affording a solid. The solid is purified by flash chromatography (silica gel; 2% methanol/methylene chloride) affording the desired product as a white crystalline solid, M.P.=151°-152° C. above (5 g) is heated slowly to about 135°-140° C. maintained at this temperature for about 10-15 min the residue is extracted with ether The organic extract is washed with 1N HCl, 10% aqueous sodium carbonate dried filtered evaporated affording a solid The solid is purified by flash chromatography (silica gel; 2% methanol/methylene chloride)

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: A neat mixture of AlCl3 (8.28 g) and the amide obtained in Step 1. above (5 g) is heated slowly to about 135°-140° C. and maintained at this temperature for about 10-15 min. Ice water is added slowly to the reaction mixture and the residue is extracted with ether. The organic extract is washed with 1N HCl, 10% aqueous sodium carbonate, dried, filtered and evaporated affording a solid. The solid is purified by flash chromatography (silica gel; 2% methanol/methylene chloride) affording the desired product as a white crystalline solid, M.P.=151°-152° C. above (5 g) is heated slowly to about 135°-140° C. maintained at this temperature for about 10-15 min the residue is extracted with ether The organic extract is washed with 1N HCl, 10% aqueous sodium carbonate dried filtered evaporated affording a solid The solid is purified by flash chromatography (silica gel; 2% methanol/methylene chloride)

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: A neat mixture of AlCl3 (8.28 g) and the amide obtained in Step 1. above (5 g) is heated slowly to about 135°-140° C. and maintained at this temperature for about 10-15 min. Ice water is added slowly to the reaction mixture and the residue is extracted with ether. The organic extract is washed with 1N HCl, 10% aqueous sodium carbonate, dried, filtered and evaporated affording a solid. The solid is purified by flash chromatography (silica gel; 2% methanol/methylene chloride) affording the desired product as a white crystalline solid, M.P.=151°-152° C. above (5 g) is heated slowly to about 135°-140° C. maintained at this temperature for about 10-15 min the residue is extracted with ether The organic extract is washed with 1N HCl, 10% aqueous sodium carbonate dried filtered evaporated affording a solid The solid is purified by flash chromatography (silica gel; 2% methanol/methylene chloride)