(3R,4S)-3-fluoro-N,N-dimethylpiperidin-4-amine

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: Following the procedures to prepare 104, racemic cis-3-fluoro-N,N-dimethylpiperidin-4-amine was converted to 1-((2-(1H-indol-3-yl)-9-methyl-6-morpholino-9H-purin-8-yl)methyl)-3-fluoro-N,N-dimethylpiperidin-4-amine. The enantiomers of the final product were separated by SFC to give 123. LCMS: M+H+=493.2. 1H-NMR (400 MHz, DMSO-d6): δ 11.5 (s, 1H), 8.61 (m, 1H), 8.13 (m, 1H), 7.42 (m, 1H), 7.14 (m, 2H), 4.27 (s, br, 4H), 3.85 (s, 3H), 3.79 (m, 6H), 3.04 (m, 1H), 2.91 (m, 1H), 2.05-2.29 (m, 5H), 1.59-1.84 (m, 2H), 1.17 (t, 1H) The enantiomers of the final product were separated by SFC