No renderable structure data available
CC(C)(C)OC(=O)N1CCSCC1Chemical Intermediate
Structures, identifiers and computed properties have been matched to the database record by CAS.
| Intermediates | tert-butyl thiomorpholine-4-carboxylate |
|---|---|
| IUPAC Name | — |
| CAS Number | 220655-09-4 |
| Database ID | 21949316 |
| Molecular Formula | — |
| Molecular Weight | — |
Product Information
tert-butyl thiomorpholine-4-carboxylate (CAS 220655-09-4) product identity, structure identifiers and related reaction data for chemical intermediate research and sourcing review.
Potential Applications
For professional research and industrial use only
Database ID 21949316
Safety Notice
For professional research and industrial use only. Review the supplier safety data sheet before handling.
Synthesis data
12 reactions · 12 references
Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-ec6a769743374b81ad58df9583bb3742Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-03a76309c11e4044a3cc590a79ab8425Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-ec6a769743374b81ad58df9583bb3742Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-03a76309c11e4044a3cc590a79ab8425Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: tert-Butyl thiomorpholine-4-carboxylate (1.91 g, 9.42 mmol) was dissolved in dichloromethane (50 ml); m-chloroperbenzoic acid (5.0 g, 19 mmol) was gradually added while cooled with ice bath, stirred, and under nitrogen atmosphere; and the reaction mixture was stirred at room temperature for 12 hours. After addition of a saturated aqueous solution of sodium thiosulfate, the reaction mixture was kept stirred for a while; and this was subjected to extraction with ethyl acetate, washed with brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. Triethylamine (8.1 ml, 58 mmol) were added to the obtained crystals; and the reaction mixture was stirred at room temperature. tert-Butoxycarbonyl dicarbonate (13.3 ml, 58 mmol) was added thereto; and the reaction mixture was stirred at room temperature for 10 hours. The reaction mixture was concentrated under reduced pressure; and the obtained crystals were suspended with a solvent mixture of diethyl ether:ethanol=10:1, filtered off, washed with diethyl ether and dried under aeration to yield the title compound as colorless crystals (2.03 g, 8.63 mmol, 91.6%). while cooled with ice bath and the reaction mixture was stirred at room temperature for 12 hours the reaction mixture was kept stirred for a while and this was subjected to extraction with ethyl acetate washed with brine dried over anhydrous sodium sulfate concentrated under reduced pressure and the reaction mixture was stirred at room temperature and the reaction mixture was stirred at room temperature for 10 hours The reaction mixture was concentrated under reduced pressure and the obtained crystals were suspended with a solvent mixture of diethyl ether ethanol=10:1, filtered off washed with diethyl ether dried under aeration
Source ID: ord-ca9ed8b2450f46f89d37934466d5ddf2Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: Thiomorpholine (5.0 ml, 53 mmol) was dissolved in tetrahydrofuran (200 ml); triethylamine (8.1 ml, 58 mmol) was added thereto; and the reaction mixture was stirred at room temperature. tert-Butoxycarbonyl dicarbonate (13.3 ml, 58 mmol) was added thereto and the reaction mixture was stirred at room temperature for 10 hours. The reaction mixture was concentrated under reduced pressure; and the residue was purified by silica gel column (eluent; hexane:ethyl acetate=from 80:20, 75:25 to 70:30) to yield the title compound as colorless crystals (10.4 g, 51 mmol). the reaction mixture was stirred at room temperature for 10 hours The reaction mixture was concentrated under reduced pressure and the residue was purified by silica gel column (eluent; hexane:ethyl acetate=from 80:20, 75:25 to 70:30)
Source ID: ord-1291f0e48b6f454687c05243ca8ecd72Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: Thiomorpholine (5.0 ml, 53 mmol) was dissolved in tetrahydrofuran (200 ml); triethylamine (8.1 ml, 58 mmol) was added thereto; and the reaction mixture was stirred at room temperature. tert-Butoxycarbonyl dicarbonate (13.3 ml, 58 mmol) was added thereto and the reaction mixture was stirred at room temperature for 10 hours. The reaction mixture was concentrated under reduced pressure; and the residue was purified by silica gel column (eluent; hexane:ethyl acetate=from 80:20, 75:25 to 70:30) to yield the title compound as colorless crystals (10.4 g, 51 mmol). the reaction mixture was stirred at room temperature for 10 hours The reaction mixture was concentrated under reduced pressure and the residue was purified by silica gel column (eluent; hexane:ethyl acetate=from 80:20, 75:25 to 70:30)
Source ID: ord-1291f0e48b6f454687c05243ca8ecd72Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: Thiomorpholine (5.0 ml, 53 mmol) was dissolved in tetrahydrofuran (200 ml); triethylamine (8.1 ml, 58 mmol) was added thereto; and the reaction mixture was stirred at room temperature. tert-Butoxycarbonyl dicarbonate (13.3 ml, 58 mmol) was added thereto and the reaction mixture was stirred at room temperature for 10 hours. The reaction mixture was concentrated under reduced pressure; and the residue was purified by silica gel column (eluent; hexane:ethyl acetate=from 80:20, 75:25 to 70:30) to yield the title compound as colorless crystals (10.4 g, 51 mmol). the reaction mixture was stirred at room temperature for 10 hours The reaction mixture was concentrated under reduced pressure and the residue was purified by silica gel column (eluent; hexane:ethyl acetate=from 80:20, 75:25 to 70:30)
Source ID: ord-1291f0e48b6f454687c05243ca8ecd72Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: tert-Butyl thiomorpholine-4-carboxylate (1.91 g, 9.42 mol) was dissolved in dichloromethane (50 ml); m-chloroperbenzoic acid (5.0 g, 19 mmol) was gradually added while cooled with ice bath, stirred, and under nitrogen atmosphere; and the reaction mixture was stirred at room temperature for 12 hours. After addition of a saturated aqueous solution of sodium thiosulfate, the reaction mixture was kept stirred for a while; and this was subjected to extraction with ethyl acetate, washed with brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. Triethylamine (8.1 ml, 58 ml) were added to the obtained crystals; and the reaction mixture was stirred at room temperature. tert-Butoxycarbonyl dicarbonate (13.3 ml, 58 mmol) was added thereto; and the reaction mixture was stirred at room temperature for 10 hours. The reaction mixture was concentrated under reduced pressure; and the obtained crystals were suspended with a solvent mixture of diethyl ether:ethanol=10:1, filtered off, washed with diethyl ether and dried under aeration to yield the title compound as colorless crystals (2.03 g, 8.63 mmol, 91.6%). while cooled with ice bath and the reaction mixture was stirred at room temperature for 12 hours the reaction mixture was kept stirred for a while and this was subjected to extraction with ethyl acetate washed with brine dried over anhydrous sodium sulfate concentrated under reduced pressure Triethylamine (8.1 ml, 58 ml) were added to the obtained crystals and the reaction mixture was stirred at room temperature and the reaction mixture was stirred at room temperature for 10 hours The reaction mixture was concentrated under reduced pressure and the obtained crystals were suspended with a solvent mixture of diethyl ether ethanol=10:1, filtered off washed with diethyl ether dried under aeration
Source ID: ord-78ccffa65a344032b23a9b0f65240757Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: Thiomorpholine (5.0 ml, 53 mol) was dissolved in tetrahydrofuran (200 ml); triethylamine (8.1 ml, 58 ml) was added thereto; and the reaction mixture was stirred at room temperature. tert-Butoxycarbonyl dicarbonate (13.3 ml, 58 mmol) was added thereto and the reaction mixture was stirred at room temperature for 10 hours. The reaction mixture was concentrated under reduced pressure; and the residue was purified by silica gel column (eluent; hexane:ethyl acetate=from 80:20, 75:25 to 70:30) to yield the title compound as colorless crystals (10.4 g, 51 mmol). the reaction mixture was stirred at room temperature for 10 hours The reaction mixture was concentrated under reduced pressure and the residue was purified by silica gel column (eluent; hexane:ethyl acetate=from 80:20, 75:25 to 70:30)
Source ID: ord-1f78b47ce5144d6ba73f778e4299dc27Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: Thiomorpholine (5.0 ml, 53 mol) was dissolved in tetrahydrofuran (200 ml); triethylamine (8.1 ml, 58 ml) was added thereto; and the reaction mixture was stirred at room temperature. tert-Butoxycarbonyl dicarbonate (13.3 ml, 58 mmol) was added thereto and the reaction mixture was stirred at room temperature for 10 hours. The reaction mixture was concentrated under reduced pressure; and the residue was purified by silica gel column (eluent; hexane:ethyl acetate=from 80:20, 75:25 to 70:30) to yield the title compound as colorless crystals (10.4 g, 51 mmol). the reaction mixture was stirred at room temperature for 10 hours The reaction mixture was concentrated under reduced pressure and the residue was purified by silica gel column (eluent; hexane:ethyl acetate=from 80:20, 75:25 to 70:30)
Source ID: ord-1f78b47ce5144d6ba73f778e4299dc27Conditions: temp:0.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A mechanically-stirred mixture of tert-butyl thiomorpholine-4-carboxylate (243 g, 1.19 mol), MeOH (1.5 L), and H2O (1.5 L) was cooled to 0° C. Solid NaIO4 (280 g, 1.3 mol) was added in portions over a 2 hour period. For convenience, the suspension was stirred for 3 days at room temperature. The solids were filtered, washing with MeOH (3×500 mL). The filtrate was concentrated. Residual water was saturated with solid NaCl, and the aqueous phase was extracted with EtOAc (4×200 mL). The combined organic phases were dried (MgSO4), filtered, and concentrated to obtain the product (255 g, 97%). The solids were filtered washing with MeOH (3×500 mL) The filtrate was concentrated the aqueous phase was extracted with EtOAc (4×200 mL) The combined organic phases were dried (MgSO4) filtered concentrated
Source ID: ord-40b3be5885594677ad86d2aec0f85ec0PubChem References
These sources are listed in the compound's public database record.
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