(3R,5S,8R,9S,10S,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-amine

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: To a solution of 2.04 g (4.83 mmol) 3α-azido-5α-cholestane in 50 ml THF, 16 ml (16 mmol) of a 1M solution of LiAlH4 in ether are carefully added dropwise. The mixture is heated for 4 h under reflow, cooled to RT, followed by cautious addition of 5 ml of a saturated NH4Cl solution. After filtration and washing of the residual filtrate twice with ether, the ether phase is dried over Na2SO4 and concentrated. The amine is obtained as white solid and directly processed further. Yield 96%, F=95-97° C. C27H49N (387.7), calc. C, 83.65; H, 12.74; N, 3.61. found: C, 83.30; H, 12.42; N, 3.65. The mixture is heated for 4 h under reflow After filtration washing of the residual filtrate twice with ether the ether phase is dried over Na2SO4 concentrated

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: To a solution of 2.04 g (4.83 mmol) 3α-azido-5α-cholestane in 50 ml THF, 16 ml (16 mmol) of a 1M solution of LiAlH4 in ether are carefully added dropwise. The mixture is heated for 4 h under reflow, cooled to RT, followed by cautious addition of 5 ml of a saturated NH4Cl solution. After filtration and washing of the residual filtrate twice with ether, the ether phase is dried over Na2SO4 and concentrated. The amine is obtained as white solid and directly processed further. Yield 96%, F=95-97° C. C27H49N (387.7), calc. C, 83.65; H, 12.74; N, 3.61. found: C, 83.30; H, 12.42; N, 3.65. The mixture is heated for 4 h under reflow After filtration washing of the residual filtrate twice with ether the ether phase is dried over Na2SO4 concentrated