N,N-dimethyl-1-[(2R)-morpholin-2-yl]methanamine

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: (S)-4-Benzyl-2-(N,N-dimethylaminomethyl)morpholine (78.9 g) was dissolved in ethanol (800 ml) and 10% palladium carbon (31.1 g) and hydrazine monohydrate (22.1 g) were added with stirring at room temperature. The mixture was refluxed with stirring for 1 hour. After cooling, the reaction mixture was filtered through celite and the solvent was distilled off to give 42.8 g of (R)-2-(N,N-dimethylaminomethyl)morpholine as a pale-yellow oil. The mixture was refluxed with stirring for 1 hour After cooling the reaction mixture was filtered through celite the solvent was distilled off

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: (S)-4-Benzyl-2-(N,N-dimethylaminomethyl)morpholine (78.9 g) was dissolved in ethanol (800 ml) and 10% palladium carbon (31.1 g) and hydrazine monohydrate (22.1 g) were added with stirring at room temperature. The mixture was refluxed with stirring for 1 hour. After cooling, the reaction mixture was filtered through celite and the solvent was distilled off to give 42.8 g of (R)-2-(N,N-dimethylaminomethyl)morpholine as a pale-yellow oil. The mixture was refluxed with stirring for 1 hour After cooling the reaction mixture was filtered through celite the solvent was distilled off