N',2-dihydroxy-2-phenylethanimidamide

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: Following the general method as outlined in Example 59, starting from (2S,4EZ)-1-(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidine-carboxylic acid (Intermediate 2), [1,1′-biphenyl]-4-carbonyl chloride, and (2RS)-N′,2-dihydroxy-2-phenylethanimidamide (an Intermediate 7), the title compound was obtained in 75% purity by HPLC. MS(ESI+): m/z=469.3.