2,4-difluorobenzenecarbothioamide

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: 2,4-Difluorobenzenecarboximidic hydrazide hydriodide salt was made from 2,4-difluorothiobenzamide using the method described in Example 24. (4-Fluoro-3-trifluoromethylphenyl)oxoacetaldehyde was reacted with 2,4-difluorobenzenecarboximidic hydrazide hydriodide salt using the method described in Example 1 to give 3-(2,4-difluorophenyl)-5-(4-fluoro-3-trifluoromethylphenyl)-[1,2,4]triazine as a yellow solid (795 mg): δH (400 MHz, CDCl3) 7.01-7.13 (2H, m), 7.45 (1H, t, J 9.2 Hz), 8.32-8.38 (1H, m), 8.46-8.50 (1H, m), 8.55 (1H, dd, J 2.3, 6.7 Hz), 9.66 (1H, s); m/z (ES+) 356.

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: 2,4-Difluorobenzenecarboximidic hydrazide hydriodide salt was made from 2,4-difluorothiobenzamide using the method described in Example 24. (4-Fluoro-3-trifluoromethylphenyl)oxoacetaldehyde was reacted with 2,4-difluorobenzenecarboximidic hydrazide hydriodide salt using the method described in Example 1 to give 3-(2,4-difluorophenyl)-5-(4-fluoro-3-trifluoromethylphenyl)-[1,2,4]triazine as a yellow solid (795 mg): δH (400 MHz, CDCl3) 7.01-7.13 (2H, m), 7.45 (1H, t, J 9.2 Hz), 8.32-8.38 (1H, m), 8.46-8.50 (1H, m), 8.55 (1H, dd, J 2.3, 6.7 Hz), 9.66 (1H, s); m/z (ES+) 356.