tert-butyl N-[(2S)-1-cyano-4-methylpentan-2-yl]carbamate

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: To a solution of the compound prepared in Reference Example 3 (2.04 g) in N,N-dimethylformamide (15 ml) were added imidazole (1.26 g) and t-butyldimethylsilylchloride (2.79 g) and the mixture was stirred for 3 hours at room temperature. To the reaction mixture was added water and was extracted with ethyl acetate. The organic layer was washed with water, saturated aqueous solution of sodium chloride and dried and concentrated. The residue was purified by column chromatography on silica gel (n-hexane:ethyl acetate=19:1) to give the title compound (3.06 g) having the following physical data. was extracted with ethyl acetate The organic layer was washed with water, saturated aqueous solution of sodium chloride dried concentrated The residue was purified by column chromatography on silica gel (n-hexane:ethyl acetate=19:1)

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: To a solution of the compound prepared in Reference Example 3 (2.04 g) in N,N-dimethylformamide (15 ml) were added imidazole (1.26 g) and t-butyldimethylsilylchloride (2.79 g) and the mixture was stirred for 3 hours at room temperature. To the reaction mixture was added water and was extracted with ethyl acetate. The organic layer was washed with water, saturated aqueous solution of sodium chloride and dried and concentrated. The residue was purified by column chromatography on silica gel (n-hexane:ethyl acetate=19:1) to give the title compound (3.06 g) having the following physical data. was extracted with ethyl acetate The organic layer was washed with water, saturated aqueous solution of sodium chloride dried concentrated The residue was purified by column chromatography on silica gel (n-hexane:ethyl acetate=19:1)