2,4,4-trimethylcyclopent-2-en-1-one

Conditions: temp:0.00; pressure:0.00; stir:

Conditions: temp:0.00; pressure:0.00; stir:

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: 124 g. of 2,4,4-trimethyl-cyclopent-2-en1-one are introduced into 67 g. of nitromethane and, after the addition of 10 ml. of a 40% solution of benzyltrimethylammonium hydroxide in methanol, stirred at 70°C. for 3 days. The mixture is then taken up in ether The ether solution is washed with 10% sulfuric acid, dried over sodium sulfate and evaporated under reduced presssure. The remaining 2,4,4-trimethyl-3-nitromethyl-cyclopentanone boils after rectification in a high vacuum at 97°-100°C/0.2 mmHg. 83 g. of the 2,4,4-trimethyl-3-nitromethyl-cyclopentanone are treated with 36 g. of sodium hydroxide in 600 ml. of water. After the addition of 300 ml. of a saturated aqueous magnesium sulfate solution, the mixture is stirred for 30 minutes, then treated dropwise at 0°C. within 1 hour with a solution of 49.7 g. of potassium permanganate in 800 ml. of water and subsequently filtered. The filtrate is extracted with methylene chloride. The extract is dried over sodium sulfate and evaporated under reduced pressure. There is obtained 1-formyl-3-oxo-2,5,5-trimethyl-cyclopentane, whose 2,4-dinitrophenylhydrazone has a melting point of 174°-177°C. is washed with 10% sulfuric acid dried over sodium sulfate evaporated under reduced presssure at 97°-100°C of the 2,4,4-trimethyl-3-nitromethyl-cyclopentanone are treated with 36 g After the addition of 300 ml treated dropwise at 0°C. within 1 hour with a solution of 49.7 g of water and subsequently filtered The filtrate is extracted with methylene chloride The extract is dried over sodium sulfate evaporated under reduced pressure

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: 2,4,4-trimethyl-cyclopent-2-en-1-one is reacted with nitromethane to give 2,4,4-trimethyl-3-nitromethyl-cyclopentanone which, after treatment with a base, is converted into 1-formyl-3-oxo-2,5,5-trimethyl-cyclopentane either with the aid of an oxidizing agent, such as potassium permanganate, ozone, or with a hydrohalic acid, a mineral acid or titanium trichloride.