2-diethoxyphosphoryl-1,1-dimethoxyethane

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: A mixture consisting of 2.3 gm (0.003mol) of erythromycylamine, 1.4 gm (0.006 mol) of diethylphosphonoacetaldehyde-dimethylacetal, 20 ml of dioxane, 2 ml of water and 12 gm of Dowex W 50 was stirred at room temperature. After 6 hours of stirring the ion exchanger was filtered off and washed with dioxane. Water was added to the filtrate until crystallization started. The white product was suction-filtered off, washed with aqueous dioxane and dried. Yield: 1.4 gm (52% of theory), m.p. 110°-113° C (decomp.). After 6 hours of stirring the ion exchanger was filtered off washed with dioxane Water was added to the filtrate until crystallization The white product was suction-filtered off washed with aqueous dioxane dried