benzyl 2-piperazin-1-ylacetate

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: The same procedure as in Example 2-(6-2) was performed with N-4-cyanobenzoyl-β-phenyl-α,α-dimethyl-β-alanine (0.4 g, 1.24 mmol) and piperazineacetic acid benzyl ester (0.87 g, 3.72 mmol) to yield an oil of N-4-cyanobenzoyl-β-phenyl-α,α-dimethyl-β-alanyl-4-piperazineacetic acid benzyl ester (0.48 g, 70.0%).

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: The same procedure as in Example 2-(6-2) was performed with N-4-cyanobenzoyl-β-phenyl-α,α-dimethyl-β-alanine (0.4 g, 1.24 mmol) and piperazineacetic acid benzyl ester (0.87 g, 3.72 mmol) to yield an oil of N-4-cyanobenzoyl-β-phenyl-α,α-dimethyl-β-alanyl-4-piperazineacetic acid benzyl ester (0.48 g, 70.0%).

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: 4-(4-Amidinobenzamidoacetyl)piperazin-1-ylacetic acid, FAB 348, is obtained analogously from 4-(4-BOC-amidinobenzamidoacetyl)piperazin-1-ylacetic acid (FAB 448; obtainable by condensing 4-BOC-amidinobenzamidoacetic acid with benzyl piperazin-1-ylacetate to give benzyl 4-(4-BOC-amidinobenzamidoacetyl)piperazin-1-ylacetate and hydrogenolyzing the benzyl ester group).

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: The same procedure as in Example 2-(6-2) was performed with N-4-cyanobenzoyl-β-phenyl-α,α-dimethyl-β-alanine (0.4 g, 1.24 mmol) and piperazineacetic acid benzyl ester (0.87 g, 3.72 mmol) to yield an oil of N-4-cyanobenzoyl-β-phenyl-α,α-dimethyl-β-alanyl-4-piperazineacetic acid benzyl ester (0.48 g, 70.0%).