No renderable structure data available
COC(=O)COC1=CC=CC(=C1)NChemical Intermediate
Structures, identifiers and computed properties have been matched to the database record by CAS.
| Intermediates | methyl 2-(3-aminophenoxy)acetate |
|---|---|
| IUPAC Name | — |
| CAS Number | 158196-47-5 |
| Database ID | 10678961 |
| Molecular Formula | — |
| Molecular Weight | — |
Product Information
methyl 2-(3-aminophenoxy)acetate (CAS 158196-47-5) product identity, structure identifiers and related reaction data for chemical intermediate research and sourcing review.
Potential Applications
For professional research and industrial use only
Database ID 10678961
Safety Notice
For professional research and industrial use only. Review the supplier safety data sheet before handling.
Synthesis data
12 reactions · 12 references
Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-a0f0fa8be9264b39ab6d773edfb0a75cConditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-e6ecc336840741d98030c0469c1e8fa2Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-f083ac8f1a6a4a069a3f53c3e1e59a68Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-b01c516839534e8aa3407dcdf39e78bdConditions: temp:100.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 10 g of 3-aminophenoxyacetic acid methylester are solved in 19 g benzyl chloride. Subsequently, 14 g of sodium carbonate are added portionwise and the temperature is raised to 100° C. The reaction mixture is stirred at this temperature for 3 hours. The insoluble salt is filtered off and washed with 100 ml of ethyl acetate. The combined filtrates are kept at 5° C. for 12 h. After the extraction with water and brine, the organic phase is dried with sodium sulfate and the solvent is removed in vacuum (50° C., 10−2 mbar). Yield: 22 g (dark oil). The insoluble salt is filtered off washed with 100 ml of ethyl acetate The combined filtrates are kept at 5° C. for 12 h After the extraction with water and brine the organic phase is dried with sodium sulfate the solvent is removed in vacuum (50° C., 10−2 mbar)
Source ID: ord-d8f41782269540beb5e0c23e78fbed88Conditions: temp:45.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 22 g of 3-aminophenoxyacetic acid methylester are solved in 63 g allyl bromide. Subsequently, 10 g of sodium carbonate are added portionwise and the temperature is raised to 45° C. The reaction mixture is stirred at this temperature for 4.5 hours. The insoluble salt is filtered off and washed with 70 g of ethyl acetate. The combined filtrates are kept at 5° C. for 12 h. After the extraction with water, the organic phase is dried with sodium sulfate and the solvent is removed in vacuum (60° C., 28 mbar). Yield: 24 g (dark oil). The insoluble salt is filtered off washed with 70 g of ethyl acetate The combined filtrates are kept at 5° C. for 12 h After the extraction with water the organic phase is dried with sodium sulfate the solvent is removed in vacuum (60° C., 28 mbar)
Source ID: ord-20083fe33d1a49cbb7c1acb3fb1d8cb1Conditions: temp:100.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 10 g of 3-aminophenoxyacetic acid methylester are solved in 19 g benzyl chloride. Subsequently, 14 g of sodium carbonate are added portionwise and the temperature is raised to 100° C. The reaction mixture is stirred at this temperature for 3 hours. The insoluble salt is filtered off and washed with 100 ml of ethyl acetate. The combined filtrates are kept at 5° C. for 12 h. After the extraction with water and brine, the organic phase is dried with sodium sulfate and the solvent is removed in vacuum (50° C., 10−2 mbar). Yield: 22 g (dark oil). The insoluble salt is filtered off washed with 100 ml of ethyl acetate The combined filtrates are kept at 5° C. for 12 h After the extraction with water and brine the organic phase is dried with sodium sulfate the solvent is removed in vacuum (50° C., 10−2 mbar)
Source ID: ord-d8f41782269540beb5e0c23e78fbed88Conditions: temp:100.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 10 g of 3-aminophenoxyacetic acid methylester are solved in 19 g benzyl chloride. Subsequently, 14 g of sodium carbonate are added portionwise and the temperature is raised to 100° C. The reaction mixture is stirred at this temperature for 3 hours. The insoluble salt is filtered off and washed with 100 ml of ethyl acetate. The combined filtrates are kept at 5° C. for 12 h. After the extraction with water and brine, the organic phase is dried with sodium sulfate and the solvent is removed in vacuum (50° C., 10−2 mbar). Yield: 22 g (dark oil). The insoluble salt is filtered off washed with 100 ml of ethyl acetate The combined filtrates are kept at 5° C. for 12 h After the extraction with water and brine the organic phase is dried with sodium sulfate the solvent is removed in vacuum (50° C., 10−2 mbar)
Source ID: ord-d8f41782269540beb5e0c23e78fbed88Conditions: temp:45.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 22 g of 3-aminophenoxyacetic acid methylester are solved in 63 g allyl bromide. Subsequently, 10 g of sodium carbonate are added portionwise and the temperature is raised to 45° C. The reaction mixture is stirred at this temperature for 4.5 hours. The insoluble salt is filtered off and washed with 70 g of ethyl acetate. The combined filtrates are kept at 5° C. for 12 h. After the extraction with water, the organic phase is dried with sodium sulfate and the solvent is removed in vacuum (60° C., 28 mbar). Yield: 24 g (dark oil). The insoluble salt is filtered off washed with 70 g of ethyl acetate The combined filtrates are kept at 5° C. for 12 h After the extraction with water the organic phase is dried with sodium sulfate the solvent is removed in vacuum (60° C., 28 mbar)
Source ID: ord-20083fe33d1a49cbb7c1acb3fb1d8cb1Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-a0f0fa8be9264b39ab6d773edfb0a75cConditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-e6ecc336840741d98030c0469c1e8fa2Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-f083ac8f1a6a4a069a3f53c3e1e59a68PubChem References
These sources are listed in the compound's public database record.
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