3,4a,5,6,7,7a-hexahydro-2H-[1,4]dioxino[2,3-c]pyrrole

Conditions: temp:70.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: A mixture of hexahydro-2H-[1,4]dioxino[2,3-c]pyrrole (0.40 g, 3.01 mmol, 1.0 eq), N-(3-ethynyl-4-fluorophenyl)-6-(3-chloropropoxy)-7-methoxyquinazolin-4-amine (0.87 g, 2.25 mmol, 0.75 eq), anhydrous K2CO3 (1.24 g, 9.0 mmol, 3.0 eq) and tetrabutylammonium iodide (55 mg, 0.15 mmol, 0.05 eq) in DMF (10 mL) was heated at 70° C. for 11 h. The reaction mixture was cooled to room temperature and quenched with water (10 mL). The resulted mixture was diluted with EtOAc (20 mL) and the organic phase was separated from the mixture. The water phase was extracted with EtOAc (20 mL×3). The combined organic phases were dried over anhydrous Na2SO4 and filtered. The filtrate was concentrated in vacuo and the residue was purified by a silica gel column chromatography (20:1 (v/v) CH2Cl2/CH3OH) to give the crude product, which was recrystallized from CH2Cl2/PE to afford the title compound as a pale yellow solid (0.47 g, 44.00%), HPLC: 96.10%. The compound was characterized by the following spectroscopic data: MS (ESI, pos. ion) m/z: 480.1 (M+1); 1H NMR (400 MHz, CDCl3) δ: 2.05 (2H, m), 2.68 (2H, m), 2.72 (2H, m), 2.95 (2H, dd, J=3.6, 10.0 Hz), 3.06 (1H, br s), 3.56 (2H, m), 3.76 (2H, m), 3.95 (3H, s), 4.08 (2H, m), 4.15 (2H, t, J=8.4 Hz), 7.20 (1H, t, J=8.8 Hz), 8.07-8.15 (2H, m), 8.43 (1H, s), 8.64 (1H, s) ppm. The reaction mixture was cooled to room temperature quenched with water (10 mL) The resulted mixture was diluted with EtOAc (20 mL) the organic phase was separated from the mixture The water phase was extracted with EtOAc (20 mL×3) The combined organic phases were dried over anhydrous Na2SO4 filtered The filtrate was concentrated in vacuo the residue was purified by a silica gel column chromatography (20:1 (v/v) CH2Cl2/CH3OH) to give the crude product, which was recrystallized from CH2Cl2/PE

Conditions: temp:70.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: A mixture of hexahydro-2H-[1,4]dioxino[2,3-c]pyrrole (0.40 g, 3.01 mmol, 1.0 eq), N-(3-ethynyl-4-fluorophenyl)-6-(3-chloropropoxy)-7-methoxyquinazolin-4-amine (0.87 g, 2.25 mmol, 0.75 eq), anhydrous K2CO3 (1.24 g, 9.0 mmol, 3.0 eq) and tetrabutylammonium iodide (55 mg, 0.15 mmol, 0.05 eq) in DMF (10 mL) was heated at 70° C. for 11 h. The reaction mixture was cooled to room temperature and quenched with water (10 mL). The resulted mixture was diluted with EtOAc (20 mL) and the organic phase was separated from the mixture. The water phase was extracted with EtOAc (20 mL×3). The combined organic phases were dried over anhydrous Na2SO4 and filtered. The filtrate was concentrated in vacuo and the residue was purified by a silica gel column chromatography (20:1 (v/v) CH2Cl2/CH3OH) to give the crude product, which was recrystallized from CH2Cl2/PE to afford the title compound as a pale yellow solid (0.47 g, 44.00%), HPLC: 96.10%. The compound was characterized by the following spectroscopic data: MS (ESI, pos. ion) m/z: 480.1 (M+1); 1H NMR (400 MHz, CDCl3) δ: 2.05 (2H, m), 2.68 (2H, m), 2.72 (2H, m), 2.95 (2H, dd, J=3.6, 10.0 Hz), 3.06 (1H, br s), 3.56 (2H, m), 3.76 (2H, m), 3.95 (3H, s), 4.08 (2H, m), 4.15 (2H, t, J=8.4 Hz), 7.20 (1H, t, J=8.8 Hz), 8.07-8.15 (2H, m), 8.43 (1H, s), 8.64 (1H, s) ppm. The reaction mixture was cooled to room temperature quenched with water (10 mL) The resulted mixture was diluted with EtOAc (20 mL) the organic phase was separated from the mixture The water phase was extracted with EtOAc (20 mL×3) The combined organic phases were dried over anhydrous Na2SO4 filtered The filtrate was concentrated in vacuo the residue was purified by a silica gel column chromatography (20:1 (v/v) CH2Cl2/CH3OH) to give the crude product, which was recrystallized from CH2Cl2/PE

Conditions: temp:70.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: A mixture of hexahydro-2H-[1,4]dioxino[2,3-c]pyrrole (0.31 g, 2.40 mmol, 1.20 eq), N-(3-ethynylphenyl)-6-(3-chloropropoxy)-7-methoxyquinazolin-4-amine (0.74 g, 2.00 mmol, 1.00 eq), anhydrous K2CO3 (1.00 g, 7.20 mmol, 3.60 eq) and tetrabutylammonium iodide (37 mg, 0.10 mmol, 0.05 eq) in DMF (8 mL) was heated at 70° C. for 11 h. The reaction mixture was cooled to room temperature and quenched with water (10 mL). The resulted mixture was diluted with EtOAc (20 mL) and the organic phase was separated from the mixture. The water phase was extracted with EtOAc (20 mL×3). The combined organic phases were dried over anhydrous Na2SO4 and concentrated in vacuo. The residue was purified by a silica gel column chromatography (20:1 (v/v) CH2Cl2/CH3OH) to give the crude product, which was recrystallized from CH2Cl2/PE to afford the title compound as a pale yellow solid (0.46 g, 50.00%), HPLC: 96.10%. The compound was characterized by the following spectroscopic data: MS (ESI, pos. ion) m/z: 461.2 (M+1); 1H NMR (400 MHz, CDCl3) δ: 1.98 (3H, s), 2.09 (2H, m), 2.73 (2H, m), 2.78 (2H, m), 2.97 (2H, dd, J=4.4, 10.4 Hz), 3.09 (1H, s), 3.55 (2H, m), 3.79 (2H, m), 3.99 (3H, s), 4.11 (2H, m), 4.22 (2H, t, J=6.8 Hz), 7.24 (2H, m), 7.25-7.28 (1H, m), 7.35 (1H, t, J=8.0 Hz), 7.67 (1H, br s), 7.80 (1H, m), 786 (1H, m) ppm. The reaction mixture was cooled to room temperature quenched with water (10 mL) The resulted mixture was diluted with EtOAc (20 mL) the organic phase was separated from the mixture The water phase was extracted with EtOAc (20 mL×3) The combined organic phases were dried over anhydrous Na2SO4 concentrated in vacuo The residue was purified by a silica gel column chromatography (20:1 (v/v) CH2Cl2/CH3OH) to give the crude product, which was recrystallized from CH2Cl2/PE

Conditions: temp:70.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: A mixture of hexahydro-2H-[1,4]dioxino[2,3-c]pyrrole (0.39 g, 3.0 mmol, 1.0 eq), N-(4-fluorophenyl)-6-(3-chloropropoxy)-7-methoxyquinazolin-4-amine (868 mg, 2.40 mmol, 0.80 eq), anhydrous K2CO3 (2.07 g, 15.0 mmol, 5.0 eq) and tetrabutylammonium iodide (55 mg, 0.15 mmol, 0.05 eq) in DMF (10 mL) was heated at 70° C. for 11 h. The reaction mixture was cooled to room temperature and quenched with water (10 mL). The resulted mixture was diluted with EtOAc (20 mL) and the organic phase was separated from the mixture. The water phase was extracted with EtOAc (20 mL×3). The combined organic phases were dried over anhydrous Na2SO4 and concentrated in vacuo. The residue was purified by a silica gel column chromatography (20:1 (v/v) CH2Cl2/CH3OH) to give the crude product, which was recrystallized from CH2Cl2/PE to afford the title compound as a pale yellow solid (196 mg, 22.00%), HPLC:96.21%. The compound was characterized by the following spectroscopic data: MS (ESI, pos. ion) m/z: 455.2 (M+1); 1H NMR (400 MHz, CDCl3) δ: 2.00 (2H, m), 2.63 (2H, m), 2.72 (2H, m), 2.90 (2H, dd, J=2.8, 6.1 Hz), 3.28 (1H, br s), 3.52 (2H, m), 3.76 (2H, m), 3.91 (3H, s), 4.05 (4H, d, J=4.4 Hz), 7.03 (1H, t, J=8.4 Hz), 7.18 (1H, s), 7.29 (1H, s), 7.63 (1H, dd, J=4.8, 8.4 Hz), 8.42 (1H, br s), 8.60 (1H, s) ppm. The reaction mixture was cooled to room temperature quenched with water (10 mL) The resulted mixture was diluted with EtOAc (20 mL) the organic phase was separated from the mixture The water phase was extracted with EtOAc (20 mL×3) The combined organic phases were dried over anhydrous Na2SO4 concentrated in vacuo The residue was purified by a silica gel column chromatography (20:1 (v/v) CH2Cl2/CH3OH) to give the crude product, which was recrystallized from CH2Cl2/PE

Conditions: temp:60.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: A mixture of hexahydro-2H-[1,4]dioxino[2,3-c]pyrrole (1.0 eq), N-(3-chloro-4-fluorophenyl)-6-(3-chloropropoxy)-7-methoxyquinazolin-4-amine (710 mg, 1.8 mmol, 0.95 eq), K2CO3 (524 mg, 3.8 mmol, 2.0 eq) and KI (16 mg, 0.095 mmol, 0.05 eq) in DMF (12 mL) was heated at 60° C. for 3 h and cooled to room temperature. The reaction mixture was quenched with water (10 mL) and diluted with EtOAc (20 mL). The organic phase was separated from the mixture, and the water phase was extracted with EtOAc (20 mL×3). The combined organic phases were dried over anhydrous Na2SO4 and concentrated in vacuo. The residue was purified by a silica gel column chromatography (20:1 (v/v) CH2Cl2/CH3OH) to give the crude product, which was recrystallized from CH2Cl2/PE to afford the title compound as a grayish-white solid (230 mg, 25.00%), HPLC: 99.11%. The compound was characterized by the following spectroscopic data: MS (ESI, pos. ion) m/z: 489.9 (M+1); 1H NMR (400 MHz, CDCl3) δ: 2.09 (2H, m), 2.74 (4H, m), 2.99 (2H, dd, J=3.3, 10.4 Hz), 3.56 (2H, m), 3.80 (2H, m), 3.99 (3H, s), 4.12 (2H, t, J=3.5 Hz), 4.22 (2H, t, J=6.8 Hz), 7.14 (1H, t, J=8.8 Hz), 7.23 (1H, s), 7.29 (1H, d, J=15.8 Hz), 7.60 (1H, m), 7.89 (1H, dd, J=2.5, 6.5 Hz), 8.63 (1H, s) ppm. cooled to room temperature The reaction mixture was quenched with water (10 mL) diluted with EtOAc (20 mL) The organic phase was separated from the mixture the water phase was extracted with EtOAc (20 mL×3) The combined organic phases were dried over anhydrous Na2SO4 concentrated in vacuo The residue was purified by a silica gel column chromatography (20:1 (v/v) CH2Cl2/CH3OH) to give the crude product, which was recrystallized from CH2Cl2/PE

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: To a solution of benzyl tetrahydro-2H-[1,4]dioxino[2,3-c]pyrrole-6(3H)-carboxylate (0.46 g, 1.94 mmol) in MeOH (20 mL) was added two drops of HCO2H followed by 20% Pd(OH)2 (50 mg). The reaction mixture was stirred under H2 for 4 h at rt and was filtered. The filtrate was concentrated in vacuo to give the crude product, which was used for the next step without further purification. was filtered The filtrate was concentrated in vacuo

Conditions: temp:70.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: A mixture of hexahydro-2H-[1,4]dioxino[2,3-c]pyrrole (0.40 g, 3.01 mmol, 1.0 eq), N-(3-ethynyl-4-fluorophenyl)-6-(3-chloropropoxy)-7-methoxyquinazolin-4-amine (0.87 g, 2.25 mmol, 0.75 eq), anhydrous K2CO3 (1.24 g, 9.0 mmol, 3.0 eq) and tetrabutylammonium iodide (55 mg, 0.15 mmol, 0.05 eq) in DMF (10 mL) was heated at 70° C. for 11 h. The reaction mixture was cooled to room temperature and quenched with water (10 mL). The resulted mixture was diluted with EtOAc (20 mL) and the organic phase was separated from the mixture. The water phase was extracted with EtOAc (20 mL×3). The combined organic phases were dried over anhydrous Na2SO4 and filtered. The filtrate was concentrated in vacuo and the residue was purified by a silica gel column chromatography (20:1 (v/v) CH2Cl2/CH3OH) to give the crude product, which was recrystallized from CH2Cl2/PE to afford the title compound as a pale yellow solid (0.47 g, 44.00%), HPLC: 96.10%. The compound was characterized by the following spectroscopic data: MS (ESI, pos. ion) m/z: 480.1 (M+1); 1H NMR (400 MHz, CDCl3) δ: 2.05 (2H, m), 2.68 (2H, m), 2.72 (2H, m), 2.95 (2H, dd, J=3.6, 10.0 Hz), 3.06 (1H, br s), 3.56 (2H, m), 3.76 (2H, m), 3.95 (3H, s), 4.08 (2H, m), 4.15 (2H, t, J=8.4 Hz), 7.20 (1H, t, J=8.8 Hz), 8.07-8.15 (2H, m), 8.43 (1H, s), 8.64 (1H, s) ppm. The reaction mixture was cooled to room temperature quenched with water (10 mL) The resulted mixture was diluted with EtOAc (20 mL) the organic phase was separated from the mixture The water phase was extracted with EtOAc (20 mL×3) The combined organic phases were dried over anhydrous Na2SO4 filtered The filtrate was concentrated in vacuo the residue was purified by a silica gel column chromatography (20:1 (v/v) CH2Cl2/CH3OH) to give the crude product, which was recrystallized from CH2Cl2/PE

Conditions: temp:70.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: A mixture of hexahydro-2H-[1,4]dioxino[2,3-c]pyrrole (0.31 g, 2.40 mmol, 1.20 eq), N-(3-ethynylphenyl)-6-(3-chloropropoxy)-7-methoxyquinazolin-4-amine (0.74 g, 2.00 mmol, 1.00 eq), anhydrous K2CO3 (1.00 g, 7.20 mmol, 3.60 eq) and tetrabutylammonium iodide (37 mg, 0.10 mmol, 0.05 eq) in DMF (8 mL) was heated at 70° C. for 11 h. The reaction mixture was cooled to room temperature and quenched with water (10 mL). The resulted mixture was diluted with EtOAc (20 mL) and the organic phase was separated from the mixture. The water phase was extracted with EtOAc (20 mL×3). The combined organic phases were dried over anhydrous Na2SO4 and concentrated in vacuo. The residue was purified by a silica gel column chromatography (20:1 (v/v) CH2Cl2/CH3OH) to give the crude product, which was recrystallized from CH2Cl2/PE to afford the title compound as a pale yellow solid (0.46 g, 50.00%), HPLC: 96.10%. The compound was characterized by the following spectroscopic data: MS (ESI, pos. ion) m/z: 461.2 (M+1); 1H NMR (400 MHz, CDCl3) δ: 1.98 (3H, s), 2.09 (2H, m), 2.73 (2H, m), 2.78 (2H, m), 2.97 (2H, dd, J=4.4, 10.4 Hz), 3.09 (1H, s), 3.55 (2H, m), 3.79 (2H, m), 3.99 (3H, s), 4.11 (2H, m), 4.22 (2H, t, J=6.8 Hz), 7.24 (2H, m), 7.25-7.28 (1H, m), 7.35 (1H, t, J=8.0 Hz), 7.67 (1H, br s), 7.80 (1H, m), 786 (1H, m) ppm. The reaction mixture was cooled to room temperature quenched with water (10 mL) The resulted mixture was diluted with EtOAc (20 mL) the organic phase was separated from the mixture The water phase was extracted with EtOAc (20 mL×3) The combined organic phases were dried over anhydrous Na2SO4 concentrated in vacuo The residue was purified by a silica gel column chromatography (20:1 (v/v) CH2Cl2/CH3OH) to give the crude product, which was recrystallized from CH2Cl2/PE

Conditions: temp:70.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: A mixture of hexahydro-2H-[1,4]dioxino[2,3-c]pyrrole (0.39 g, 3.0 mmol, 1.0 eq), N-(4-fluorophenyl)-6-(3-chloropropoxy)-7-methoxyquinazolin-4-amine (868 mg, 2.40 mmol, 0.80 eq), anhydrous K2CO3 (2.07 g, 15.0 mmol, 5.0 eq) and tetrabutylammonium iodide (55 mg, 0.15 mmol, 0.05 eq) in DMF (10 mL) was heated at 70° C. for 11 h. The reaction mixture was cooled to room temperature and quenched with water (10 mL). The resulted mixture was diluted with EtOAc (20 mL) and the organic phase was separated from the mixture. The water phase was extracted with EtOAc (20 mL×3). The combined organic phases were dried over anhydrous Na2SO4 and concentrated in vacuo. The residue was purified by a silica gel column chromatography (20:1 (v/v) CH2Cl2/CH3OH) to give the crude product, which was recrystallized from CH2Cl2/PE to afford the title compound as a pale yellow solid (196 mg, 22.00%), HPLC:96.21%. The compound was characterized by the following spectroscopic data: MS (ESI, pos. ion) m/z: 455.2 (M+1); 1H NMR (400 MHz, CDCl3) δ: 2.00 (2H, m), 2.63 (2H, m), 2.72 (2H, m), 2.90 (2H, dd, J=2.8, 6.1 Hz), 3.28 (1H, br s), 3.52 (2H, m), 3.76 (2H, m), 3.91 (3H, s), 4.05 (4H, d, J=4.4 Hz), 7.03 (1H, t, J=8.4 Hz), 7.18 (1H, s), 7.29 (1H, s), 7.63 (1H, dd, J=4.8, 8.4 Hz), 8.42 (1H, br s), 8.60 (1H, s) ppm. The reaction mixture was cooled to room temperature quenched with water (10 mL) The resulted mixture was diluted with EtOAc (20 mL) the organic phase was separated from the mixture The water phase was extracted with EtOAc (20 mL×3) The combined organic phases were dried over anhydrous Na2SO4 concentrated in vacuo The residue was purified by a silica gel column chromatography (20:1 (v/v) CH2Cl2/CH3OH) to give the crude product, which was recrystallized from CH2Cl2/PE

Conditions: temp:60.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: A mixture of hexahydro-2H-[1,4]dioxino[2,3-c]pyrrole (1.0 eq), N-(3-chloro-4-fluorophenyl)-6-(3-chloropropoxy)-7-methoxyquinazolin-4-amine (710 mg, 1.8 mmol, 0.95 eq), K2CO3 (524 mg, 3.8 mmol, 2.0 eq) and KI (16 mg, 0.095 mmol, 0.05 eq) in DMF (12 mL) was heated at 60° C. for 3 h and cooled to room temperature. The reaction mixture was quenched with water (10 mL) and diluted with EtOAc (20 mL). The organic phase was separated from the mixture, and the water phase was extracted with EtOAc (20 mL×3). The combined organic phases were dried over anhydrous Na2SO4 and concentrated in vacuo. The residue was purified by a silica gel column chromatography (20:1 (v/v) CH2Cl2/CH3OH) to give the crude product, which was recrystallized from CH2Cl2/PE to afford the title compound as a grayish-white solid (230 mg, 25.00%), HPLC: 99.11%. The compound was characterized by the following spectroscopic data: MS (ESI, pos. ion) m/z: 489.9 (M+1); 1H NMR (400 MHz, CDCl3) δ: 2.09 (2H, m), 2.74 (4H, m), 2.99 (2H, dd, J=3.3, 10.4 Hz), 3.56 (2H, m), 3.80 (2H, m), 3.99 (3H, s), 4.12 (2H, t, J=3.5 Hz), 4.22 (2H, t, J=6.8 Hz), 7.14 (1H, t, J=8.8 Hz), 7.23 (1H, s), 7.29 (1H, d, J=15.8 Hz), 7.60 (1H, m), 7.89 (1H, dd, J=2.5, 6.5 Hz), 8.63 (1H, s) ppm. cooled to room temperature The reaction mixture was quenched with water (10 mL) diluted with EtOAc (20 mL) The organic phase was separated from the mixture the water phase was extracted with EtOAc (20 mL×3) The combined organic phases were dried over anhydrous Na2SO4 concentrated in vacuo The residue was purified by a silica gel column chromatography (20:1 (v/v) CH2Cl2/CH3OH) to give the crude product, which was recrystallized from CH2Cl2/PE

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: To a solution of benzyl tetrahydro-2H-[1,4]dioxino[2,3-c]pyrrole-6(3H)-carboxylate (0.46 g, 1.94 mmol) in MeOH (20 mL) was added two drops of HCO2H followed by 20% Pd(OH)2 (50 mg). The reaction mixture was stirred under H2 for 4 h at rt and was filtered. The filtrate was concentrated in vacuo to give the crude product, which was used for the next step without further purification. was filtered The filtrate was concentrated in vacuo