No renderable structure data available
C1COCCN1C(C#N)C2=CC=CC=C2Chemical Intermediate
Structures, identifiers and computed properties have been matched to the database record by CAS.
| Intermediates | 2-morpholin-4-yl-2-phenylacetonitrile |
|---|---|
| IUPAC Name | — |
| CAS Number | 15190-10-0 |
| Database ID | 85812 |
| Molecular Formula | — |
| Molecular Weight | — |
Product Information
2-morpholin-4-yl-2-phenylacetonitrile (CAS 15190-10-0) product identity, structure identifiers and related reaction data for chemical intermediate research and sourcing review.
Potential Applications
For professional research and industrial use only
Database ID 85812
Safety Notice
For professional research and industrial use only. Review the supplier safety data sheet before handling.
Synthesis data
8 reactions · 8 references
Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-4c90a3462a0d409abd8fcb694e112f1fConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: NaH (0.975 mol) was washed with hexane. After the hexane was decanted off, the NaH was stirred in DMF (1950 mL) at room temperature. Morpholin-4-yl-phenyl-acetonitrile (0.70 mol) in DMF (300 mL) was added dropwise under N2 gas. The reaction mixture was stirred at room temperature for 2 hours. The reaction mixture was cooled in an ice bath and 4-chloro-2-dimethoxymethyl-1-nitrobenzene (0.86 mol) in DMF (150 mL) was added dropwise. The reaction mixture was stirred at 0° C. for 2 hours and at room temperature overnight. The reaction mixture was poured on ice/water and extracted with diisopropyl ether. The organic layer washed with water, dried (MgSO4) and evaporated to yield the title compound as a solid. After the hexane was decanted off The reaction mixture was stirred at room temperature for 2 hours The reaction mixture was cooled in an ice bath The reaction mixture was stirred at 0° C. for 2 hours and at room temperature overnight The reaction mixture was poured on ice/water extracted with diisopropyl ether The organic layer washed with water dried (MgSO4) evaporated
Source ID: ord-1d31b37ec4e2482dbbf6c21164ab279fConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: NaH (0.975 mol) was washed with hexane. After the hexane was decanted off, the NaH was stirred in DMF (1950 mL) at room temperature. Morpholin-4-yl-phenyl-acetonitrile (0.70 mol) in DMF (300 mL) was added dropwise under N2 gas. The reaction mixture was stirred at room temperature for 2 hours. The reaction mixture was cooled in an ice bath and 4-chloro-2-dimethoxymethyl-1-nitrobenzene (0.86 mol) in DMF (150 mL) was added dropwise. The reaction mixture was stirred at 0° C. for 2 hours and at room temperature overnight. The reaction mixture was poured on ice/water and extracted with diisopropyl ether. The organic layer washed with water, dried (MgSO4) and evaporated to yield the title compound as a solid. After the hexane was decanted off The reaction mixture was stirred at room temperature for 2 hours The reaction mixture was cooled in an ice bath The reaction mixture was stirred at 0° C. for 2 hours and at room temperature overnight The reaction mixture was poured on ice/water extracted with diisopropyl ether The organic layer washed with water dried (MgSO4) evaporated
Source ID: ord-1d31b37ec4e2482dbbf6c21164ab279fConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: NaH (0.975 mol) was washed with hexane. After the hexane was decanted off, the NaH was stirred in DMF (1950 mL) at room temperature. Morpholin-4-yl-phenyl-acetonitrile (0.70 mol) in DMF (300 mL) was added dropwise under N2 gas. The reaction mixture was stirred at room temperature for 2 hours. The reaction mixture was cooled in an ice bath and 4-chloro-2-dimethoxymethyl-1-nitrobenzene (0.86 mol) in DMF (150 mL) was added dropwise. The reaction mixture was stirred at 0° C. for 2 hours and at room temperature overnight. The reaction mixture was poured on ice/water and extracted with diisopropyl ether. The organic layer washed with water, dried (MgSO4) and evaporated to yield the title compound as a solid. After the hexane was decanted off The reaction mixture was stirred at room temperature for 2 hours The reaction mixture was cooled in an ice bath The reaction mixture was stirred at 0° C. for 2 hours and at room temperature overnight The reaction mixture was poured on ice/water extracted with diisopropyl ether The organic layer washed with water dried (MgSO4) evaporated
Source ID: ord-1d31b37ec4e2482dbbf6c21164ab279fConditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-4c90a3462a0d409abd8fcb694e112f1fConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: NaH (0.975 mol) was washed with hexane. After the hexane was decanted off, the NaH was stirred in DMF (1950 mL) at room temperature. Morpholin-4-yl-phenyl-acetonitrile (0.70 mol) in DMF (300 mL) was added dropwise under N2 gas. The reaction mixture was stirred at room temperature for 2 hours. The reaction mixture was cooled in an ice bath and 4-chloro-2-dimethoxymethyl-1-nitrobenzene (0.86 mol) in DMF (150 mL) was added dropwise. The reaction mixture was stirred at 0° C. for 2 hours and at room temperature overnight. The reaction mixture was poured on ice/water and extracted with diisopropyl ether. The organic layer washed with water, dried (MgSO4) and evaporated to yield the title compound as a solid. After the hexane was decanted off The reaction mixture was stirred at room temperature for 2 hours The reaction mixture was cooled in an ice bath The reaction mixture was stirred at 0° C. for 2 hours and at room temperature overnight The reaction mixture was poured on ice/water extracted with diisopropyl ether The organic layer washed with water dried (MgSO4) evaporated
Source ID: ord-55a1f5e107c14e8697880f43e929cea7Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: NaH (0.975 mol) was washed with hexane. After the hexane was decanted off, the NaH was stirred in DMF (1950 mL) at room temperature. Morpholin-4-yl-phenyl-acetonitrile (0.70 mol) in DMF (300 mL) was added dropwise under N2 gas. The reaction mixture was stirred at room temperature for 2 hours. The reaction mixture was cooled in an ice bath and 4-chloro-2-dimethoxymethyl-1-nitrobenzene (0.86 mol) in DMF (150 mL) was added dropwise. The reaction mixture was stirred at 0° C. for 2 hours and at room temperature overnight. The reaction mixture was poured on ice/water and extracted with diisopropyl ether. The organic layer washed with water, dried (MgSO4) and evaporated to yield the title compound as a solid. After the hexane was decanted off The reaction mixture was stirred at room temperature for 2 hours The reaction mixture was cooled in an ice bath The reaction mixture was stirred at 0° C. for 2 hours and at room temperature overnight The reaction mixture was poured on ice/water extracted with diisopropyl ether The organic layer washed with water dried (MgSO4) evaporated
Source ID: ord-1106e43de9964d15ba9fc24340713797Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: NaH (0.975 mol) was washed with hexane. After the hexane was decanted off, the NaH was stirred in DMF (1950 mL) at room temperature. Morpholin-4-yl-phenyl-acetonitrile (0.70 mol) in DMF (300 mL) was added dropwise under N2 gas. The reaction mixture was stirred at room temperature for 2 hours. The reaction mixture was cooled in an ice bath and 4-chloro-2-dimethoxymethyl-1-nitrobenzene (0.86 mol) in DMF (150 mL) was added dropwise. The reaction mixture was stirred at 0° C. for 2 hours and at room temperature overnight. The reaction mixture was poured on ice/water and extracted with diisopropyl ether. The organic layer washed with water, dried (MgSO4) and evaporated to yield the title compound as a solid. After the hexane was decanted off The reaction mixture was stirred at room temperature for 2 hours The reaction mixture was cooled in an ice bath The reaction mixture was stirred at 0° C. for 2 hours and at room temperature overnight The reaction mixture was poured on ice/water extracted with diisopropyl ether The organic layer washed with water dried (MgSO4) evaporated
Source ID: ord-1d31b37ec4e2482dbbf6c21164ab279fPubChem References
These sources are listed in the compound's public database record.
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