(5S)-5-(aminomethyl)pyrrolidin-2-one

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: The (S)-5-(aminomethyl)pyrrolidin-2-one was reacted with 3-bromo-6-fluoroimidazo[1,2-b]pyridazine under the amine displacement conditions described in example 5.6.42, Part A, to obtain the titled in 62% yield. 1H NMR (400 MHz, METHANOL-d4) δ ppm 1.90-2.04 (m, 1H) 2.24-2.50 (m, 3H) 3.46-3.56 (m, 2H) 4.09 (quin, J=5.84 Hz, 1H) 6.74 (d, J=9.70 Hz, 1H) 7.43 (s, 1H) 7.60 (d, J=9.70 Hz, 1H); LRMS (ESI) m/310.0 doublet [(M+H)+, calcd for C11H12BrN5O 309.0]. to obtain the

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: The (S)-5-(aminomethyl)pyrrolidin-2-one was reacted with 3-bromo-6-fluoroimidazo[1,2-b]pyridazine under the amine displacement conditions described in example 5.6.42, Part A, to obtain the titled in 62% yield. 1H NMR (400 MHz, METHANOL-d4) δ ppm 1.90-2.04 (m, 1H) 2.24-2.50 (m, 3H) 3.46-3.56 (m, 2H) 4.09 (quin, J=5.84 Hz, 1H) 6.74 (d, J=9.70 Hz, 1H) 7.43 (s, 1H) 7.60 (d, J=9.70 Hz, 1H); LRMS (ESI) m/310.0 doublet [(M+H)+, calcd for C11H12BrN5O 309.0]. to obtain the

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: The (S)-5-(aminomethyl)pyrrolidin-2-one was reacted with 3-bromo-6-fluoroimidazo[1,2-b]pyridazine under the amine displacement conditions described in example 5.6.42, Part A, to obtain the titled in 62% yield. 1H NMR (400 MHz, METHANOL-d4) δ ppm 1.90-2.04 (m, 1H) 2.24-2.50 (m, 3H) 3.46-3.56 (m, 2H) 4.09 (quin, J=5.84 Hz, 1H) 6.74 (d, J=9.70 Hz, 1H) 7.43 (s, 1H) 7.60 (d, J=9.70 Hz, 1H); LRMS (ESI) m/310.0 doublet [(M+H)+, calcd for C11H12BrN5O 309.0]. to obtain the