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C1=CC=C(C=C1)CC2=CC=C(C=C2)CClChemical Intermediate
Structures, identifiers and computed properties have been matched to the database record by CAS.
| Intermediates | 1-benzyl-4-(chloromethyl)benzene |
|---|---|
| IUPAC Name | — |
| CAS Number | 14297-39-3 |
| Database ID | 84334 |
| Molecular Formula | — |
| Molecular Weight | — |
Product Information
1-benzyl-4-(chloromethyl)benzene (CAS 14297-39-3) product identity, structure identifiers and related reaction data for chemical intermediate research and sourcing review.
Potential Applications
For professional research and industrial use only
Database ID 84334
Safety Notice
For professional research and industrial use only. Review the supplier safety data sheet before handling.
Synthesis data
10 reactions · 10 references
Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-d39bcde50c2c46d38aa780ebb0cc40deConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To a solution of 4-benzylbenzyl chloride (198.34 g) in dimethylchloride (DMF) (50 ml) was added in turn sodium hydrogen carbonate (76.88 g) and sodium cyanide (56.07 g). In that case, the solution was cooled as occasion demands, since heat is slightly generated. After stirring at room temperature for 17 hours, DMF (100 ml) was further added. After stirring at room temperature for 67 hours, ethyl acetate (300 ml) was added, and the precipitate was filtered, washed with ethyl acetate (300 ml). The filtrate and the washings were combined, washed with saturated aqueouse sodium chloride solution (20 ml×4), dried over anhydrous sodium sulfate, concentrated under reduced pressure to give the title compound (189.69 g). In that case, the solution was cooled as occasion demands since heat After stirring at room temperature for 67 hours the precipitate was filtered washed with ethyl acetate (300 ml) washed with saturated aqueouse sodium chloride solution (20 ml×4) dried over anhydrous sodium sulfate concentrated under reduced pressure
Source ID: ord-4c1ecbddd4414acc87fc0d9410bce41bConditions: temp:0.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 4-benzylbenzyl alcohol (181.47 g) was dissolved into chloroform (100 ml), and thionyl chloride (66.8 ml) was added with stirring at a 0° C. After stirring at 0° C. for 4 hours, reaction mixture was concentrated under reduced pressure to give the title compound (198.34 g). This product was used in the subsequent procedure without purification. was added After stirring at 0° C. for 4 hours reaction mixture was concentrated under reduced pressure
Source ID: ord-398b48610b59430bad1b318ae6ff4a76Conditions: temp:0.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 4-benzylbenzyl alcohol (181.47 g) was dissolved into chloroform (100 ml), and thionyl chloride (66.8 ml) was added with stirring at a 0° C. After stirring at 0° C. for 4 hours, reaction mixture was concentrated under reduced pressure to give the title compound (198.34 g). This product was used in the subsequent procedure without purification. was added After stirring at 0° C. for 4 hours reaction mixture was concentrated under reduced pressure
Source ID: ord-398b48610b59430bad1b318ae6ff4a76Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-d39bcde50c2c46d38aa780ebb0cc40deConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To a solution of 4-benzylbenzyl chloride (198.34 g) in dimethylchloride (DMF) (50 ml) was added in turn sodium hydrogen carbonate (76.88 g) and sodium cyanide (56.07 g). In that case, the solution was cooled as occasion demands, since heat is slightly generated. After stirring at room temperature for 17 hours, DMF (100 ml) was further added. After stirring at room temperature for 67 hours, ethyl acetate (300 ml) was added, and the precipitate was filtered, washed with ethyl acetate (300 ml). The filtrate and the washings were combined, washed with saturated aqueouse sodium chloride solution (20 ml×4), dried over anhydrous sodium sulfate, concentrated under reduced pressure to give the title compound (189.69 g). In that case, the solution was cooled as occasion demands since heat After stirring at room temperature for 67 hours the precipitate was filtered washed with ethyl acetate (300 ml) washed with saturated aqueouse sodium chloride solution (20 ml×4) dried over anhydrous sodium sulfate concentrated under reduced pressure
Source ID: ord-baf799d6036b470ebd16cdd14f1468d7Conditions: temp:0.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 4-benzylbenzyl alcohol (181.47 g) was dissolved into chloroform (100 ml), and thionyl chloride (66.8 ml) was added with stirring at a 0° C. After stirring at 0° C. for 4 hours, reaction mixture was concentrated under reduced pressure to give the title compound (198.34 g). This product was used in the subsequent procedure without purification. was added After stirring at 0° C. for 4 hours reaction mixture was concentrated under reduced pressure
Source ID: ord-c2e8066147ea49d88dd46e764deb3f52Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To a solution of 4-benzylbenzyl chloride (198.34 g) in dimethylchloride (DMF) (50 ml) was added in turn sodium hydrogen carbonate (76.88 g) and sodium cyanide (56.07 g). In that case, the solution was cooled as occasion demands, since heat is slightly generated. After stirring at room temperature for 17 hours, DMF (100 ml) was further added. After stirring at room temperature for 67 hours, ethyl acetate (300 ml) was added, and the precipitate was filtered, washed with ethyl acetate (300 ml). The filtrate and the washings were combined, washed with saturated aqueouse sodium chloride solution (20 ml×4), dried over anhydrous sodium sulfate, concentrated under reduced pressure to give the title compound (189.69 g). In that case, the solution was cooled as occasion demands since heat After stirring at room temperature for 67 hours the precipitate was filtered washed with ethyl acetate (300 ml) washed with saturated aqueouse sodium chloride solution (20 ml×4) dried over anhydrous sodium sulfate concentrated under reduced pressure
Source ID: ord-4c1ecbddd4414acc87fc0d9410bce41bConditions: temp:0.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 4-benzylbenzyl alcohol (181.47 g) was dissolved into chloroform (100 ml), and thionyl chloride (66.8 ml) was added with stirring at a 0° C. After stirring at 0° C. for 4 hours, reaction mixture was concentrated under reduced pressure to give the title compound (198.34 g). This product was used in the subsequent procedure without purification. was added After stirring at 0° C. for 4 hours reaction mixture was concentrated under reduced pressure
Source ID: ord-398b48610b59430bad1b318ae6ff4a76Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-d39bcde50c2c46d38aa780ebb0cc40dePubChem References
These sources are listed in the compound's public database record.
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