N',N'-dipropylethane-1,2-diamine

Conditions: temp:0.00; pressure:0.00; stir:

Conditions: temp:0.00; pressure:0.00; stir:

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: N1,N1-Dipropyl-1,2-ethanediamine (297) (0.27 g, 1.9 mmol) was added to a stirred solution of chloride 21 (298 mg, 1.3 mmol) in DME (50 mL) and the solution stirred at reflux temperature for 2 h. The solvent was evaporated and the residue partitioned between DCM (100 mL) and dilute aqueous NH3 solution (50 mL). The organic fraction was dried and the solvent evaporated. The residue was purified by chromatography, eluting with a gradient (0-10%) of MeOH/DCM, to give 1-oxide 28 (325 mg, 74%) as a yellow powder: mp (MeOH/EtOAc) 95-97° C.; 1H NMR δ 8.07 (s, 1H, H-9), 7.39 (s, 1H, H-5), 5.80 (br s, 1H, NH), 3.46-3.53 (m, 2H, CH2N), 2.96-3.03 (m, 4H, 2×CH2N), 2.68 (dd, J=6.0, 5.8 Hz, 2H, CH2N), 2.38-2.45 (m, 4H, H-6, H-8), 2.10-2.18 (m, 2H, H-7), 1.41-1.51 (m, 4H, 2×CH2), 0.87 (t, J=7.1 Hz, 6H, 2×CH3); 13C NMR δ 158.7, 154.4, 148.8, 143.0, 129.8, 120.5, 114.7, 55.9 (2), 52.6, 38.9, 31.1, 32.3, 25.7, 20.3 (2), 11.9 (2). Anal. calcd for C18H27N5O: C, 65.6; H, 8.3; N, 21.3. Found: C, 65.4; H, 8.4; N, 21.3%. at reflux temperature for 2 h The solvent was evaporated the residue partitioned between DCM (100 mL) and dilute aqueous NH3 solution (50 mL) The organic fraction was dried the solvent evaporated The residue was purified by chromatography eluting with a gradient (0-10%) of MeOH/DCM

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: N,N-Dipropyl-1,2-ethanediamine (297) (0.53 g, 3.7 mmol) was added to a stirred solution of chloride 5 (325 mg, 1.5 mmol) in DME (30 mL) and the solution stirred at reflux temperature for 2 h. The solvent was evaporated and the residue was partitioned between DCM (100 mL) and dilute aqueous NH3 solution (50 mL). The organic fraction was dried and the solvent evaporated. The residue was purified by chromatography, eluting with a gradient (0-10%) of MeOH/DCM, to give 1-oxide 10 (454 mg, 94%) as a pale yellow solid: mp (MeOH) 148-151° C.; 1H NMR δ 7.54 (d, J=8.4 Hz, 1H, H-6), 7.40 (d, J=8.4 Hz, 1H, H-5), 5.77 (br s, 1H, NH), 3.63-3.68 (m, 2H, H-9), 3.48-3.52 (m, 2H, CH2N), 2.95-3.00 (m, 2H, H-7), 2.68 (dd, J=6.0, 5.8 Hz, 2H, CH2N), 2.40-2.45 (m, 4H, 2×CH2N), 2.16-2.23 (m, 2H, H-8), 1.43-1.52 (m, 4H, 2×CH2), 0.90 (t, J=7.3 Hz, 6H, 2×CH3); 13C NMR δ 158.5, 149.0, 142.0, 137.3, 132.2, 129.2, 124.7, 55.9 (2), 52.6, 38.9, 35.3, 32.9, 24.8, 20.3 (2), 11.9 (2). Anal. calcd for C18H27N5O: C, 65.6; H, 8.3; N, 21.3. Found: C, 65.7; H, 8.6; N, 21.5%. at reflux temperature for 2 h The solvent was evaporated the residue was partitioned between DCM (100 mL) and dilute aqueous NH3 solution (50 mL) The organic fraction was dried the solvent evaporated The residue was purified by chromatography eluting with a gradient (0-10%) of MeOH/DCM