methyl 3-azabicyclo[3.2.1]octane-8-carboxylate;hydrochloride

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: Prepared from methyl 3-azabicyclo[3.2.1]octane-8-carboxylate hydrochloride (0.57 g, 2.8 mmol) and (2-chloropyrimidin-5-yl)boronic acid (0.45 g, 2.8 mmol) in accordance with General Method C to afford the title compound (1 g) as an off-white gum. LCMS (pH 3) MH+ 292, RT 0.79 minutes.

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: Prepared from methyl 3-azabicyclo[3.2.1]octane-8-carboxylate hydrochloride (0.57 g, 2.8 mmol) and (2-chloropyrimidin-5-yl)boronic acid (0.45 g, 2.8 mmol) in accordance with General Method C to afford the title compound (1 g) as an off-white gum. LCMS (pH 3) MH+ 292, RT 0.79 minutes.