N-methyl-1-(2-phenylphenyl)methanamine

Conditions: temp:0.00; pressure:0.00; stir:

Conditions: temp:0.00; pressure:0.00; stir:

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: N-methyl-2-phenylbenzylamine (2.57 g) was dissolved in 17 ml of N,N-dimethylformamide (DMF), followed by the addition of 1.39 g of sodium carbonate. While stirring the resulting mixture under ice cooling, a solution of 2.5 g of 1-bromo-6,6-dimethyl-2-hepten-4-yne in DMF was added dropwise. The temperature of the mixture was allowed to rise to room temperature, at which a reaction was allowed to proceed for 16 hours. After the reaction mixture was concentrated under reduced pressure, water and diethyl ether were added to subject the resulting concentrate to liquid-liquid extraction. The organic layer was collected and then dried over magnesium sulfate. The solvent was then distilled off. The residue was purified by chromatography on a silica gel (eluent:hexane/ethyl acetate=10/1), whereby trans-N-(6,6-dimethyl-2-hepten-4-yn-1-yl)-N-methyl-2-phenylbenzylamine (Compound 5) and cis-N-(6,6-dimethyl-2-hepten-4-yn-1-yl)-N-methyl-2-phenylbenzylamine (Compound 6) were obtained in amounts of 2.15 g (yield: 54.5%) and 0.73 g (yield: 18.5%), respectively. The followings are their NMR spectrum data: to rise to room temperature, at which After the reaction mixture was concentrated under reduced pressure, water and diethyl ether were added concentrate to liquid-liquid extraction The organic layer was collected dried over magnesium sulfate The solvent was then distilled off The residue was purified by chromatography on a silica gel (eluent:hexane/ethyl acetate=10/1), whereby trans-N-(6,6-dimethyl-2-hepten-4-yn-1-yl)-N-methyl-2-phenylbenzylamine (Compound 5)

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: Orthophenylbenzoic acid (10 g) and thionyl chloride (18.7 g) were mixed with 100 ml of chloroform, followed by heating for 4 hours under reflux. The reaction mixture was concentrated under reduced pressure, and the resulting concentrate was added dropwise to 40 ml of a 40% aqueous solution of methylamine under ice cooling. The temperature of the resulting mixture was allowed to rise to room temperature, at which a reaction was allowed to proceed under stirring for 4 days. 2 N hydrochloric acid was added to terminate the reaction, followed by the extraction of the resulting mixture with chloroform. The organic layer was washed with a saturated aqueous solution of sodium hydrogencarbonate. The organic layer was collected, from which the solvent was distilled off so that N-methyl-2-phenylbenzoic acid amide was obtained. The acid amide was reduced with 0.54 g of lithium aluminum hydride in diethyl ether, whereby 1.46 g of N-methyl-2-phenylbenzylamine were obtained. The benzylamine was reacted with an acid chloride, which had been derived from 1.45 g of p-tert-butylbenzoic acid, in the presence of triethylamine in benzene. Water and chloroform were added to the reaction mixture for extraction. The organic layer was collected and was then washed successively with dilute hydrochloric acid, a saturated aqueous solution of sodium hydrogencarbonate, water and a saturated aqueous solution of sodium chloride in the order that they are presented. The solvent was distilled off, whereby 2.42 g of N-methyl-N-(2-phenylbenzyl)-4-tert-butylbenzoic acid amide were obtained as yellow crystals. The acid amide was reduced with lithium aluminum hydride in tetrahydrofuran and the reduction product was extracted with diethyl ether, whereby 0.83 g of 4-tert-butyl-N-methyl-N-(2-phenylbenzyl)benzylamine (Compound 1) was obtained (yield: 35.7%). The following is its NMR spectrum data. The organic layer was collected was then washed successively with dilute hydrochloric acid The solvent was distilled off

Conditions: temp:0.00; pressure:0.00; stir:

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: N-methyl-2-phenylbenzylamine (2.57 g) was dissolved in 17 ml of N,N-dimethylformamide (DMF), followed by the addition of 1.39 g of sodium carbonate. While stirring the resulting mixture under ice cooling, a solution of 2.5 g of 1-bromo-6,6-dimethyl-2-hepten-4-yne in DMF was added dropwise. The temperature of the mixture was allowed to rise to room temperature, at which a reaction was allowed to proceed for 16 hours. After the reaction mixture was concentrated under reduced pressure, water and diethyl ether were added to subject the resulting concentrate to liquid-liquid extraction. The organic layer was collected and then dried over magnesium sulfate. The solvent was then distilled off. The residue was purified by chromatography on a silica gel (eluent:hexane/ethyl acetate=10/1), whereby trans-N-(6,6-dimethyl-2-hepten-4-yn-1-yl)-N-methyl-2-phenylbenzylamine (Compound 5) and cis-N-(6,6-dimethyl-2-hepten-4-yn-1-yl)-N-methyl-2-phenylbenzylamine (Compound 6) were obtained in amounts of 2.15 g (yield: 54.5%) and 0.73 g (yield: 18.5%), respectively. The followings are their NMR spectrum data: to rise to room temperature, at which After the reaction mixture was concentrated under reduced pressure, water and diethyl ether were added concentrate to liquid-liquid extraction The organic layer was collected dried over magnesium sulfate The solvent was then distilled off The residue was purified by chromatography on a silica gel (eluent:hexane/ethyl acetate=10/1), whereby trans-N-(6,6-dimethyl-2-hepten-4-yn-1-yl)-N-methyl-2-phenylbenzylamine (Compound 5)

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: Orthophenylbenzoic acid (10 g) and thionyl chloride (18.7 g) were mixed with 100 ml of chloroform, followed by heating for 4 hours under reflux. The reaction mixture was concentrated under reduced pressure, and the resulting concentrate was added dropwise to 40 ml of a 40% aqueous solution of methylamine under ice cooling. The temperature of the resulting mixture was allowed to rise to room temperature, at which a reaction was allowed to proceed under stirring for 4 days. 2 N hydrochloric acid was added to terminate the reaction, followed by the extraction of the resulting mixture with chloroform. The organic layer was washed with a saturated aqueous solution of sodium hydrogencarbonate. The organic layer was collected, from which the solvent was distilled off so that N-methyl-2-phenylbenzoic acid amide was obtained. The acid amide was reduced with 0.54 g of lithium aluminum hydride in diethyl ether, whereby 1.46 g of N-methyl-2-phenylbenzylamine were obtained. The benzylamine was reacted with an acid chloride, which had been derived from 1.45 g of p-tert-butylbenzoic acid, in the presence of triethylamine in benzene. Water and chloroform were added to the reaction mixture for extraction. The organic layer was collected and was then washed successively with dilute hydrochloric acid, a saturated aqueous solution of sodium hydrogencarbonate, water and a saturated aqueous solution of sodium chloride in the order that they are presented. The solvent was distilled off, whereby 2.42 g of N-methyl-N-(2-phenylbenzyl)-4-tert-butylbenzoic acid amide were obtained as yellow crystals. The acid amide was reduced with lithium aluminum hydride in tetrahydrofuran and the reduction product was extracted with diethyl ether, whereby 0.83 g of 4-tert-butyl-N-methyl-N-(2-phenylbenzyl)benzylamine (Compound 1) was obtained (yield: 35.7%). The following is its NMR spectrum data. The organic layer was collected was then washed successively with dilute hydrochloric acid The solvent was distilled off