No renderable structure data available
C1=CC(=C(C=C1F)F)S(=O)(=O)NChemical Intermediate
Structures, identifiers and computed properties have been matched to the database record by CAS.
| Intermediates | 2,4-difluorobenzenesulfonamide |
|---|---|
| IUPAC Name | — |
| CAS Number | 13656-60-5 |
| Database ID | 574964 |
| Molecular Formula | — |
| Molecular Weight | — |
Product Information
2,4-difluorobenzenesulfonamide (CAS 13656-60-5) product identity, structure identifiers and related reaction data for chemical intermediate research and sourcing review.
Potential Applications
For professional research and industrial use only
Database ID 574964
Safety Notice
For professional research and industrial use only. Review the supplier safety data sheet before handling.
Synthesis data
12 reactions · 12 references
Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-c1b21ea7f6474ef8ab31205de8a1ccf1Conditions: temp:120.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To a solution of 2,4-difluorobenzenesulfonamide (1.56 g) and 1-((4′-chlorobiphenyl-2-yl)methyl)piperazine (2.32 g) in dimethylsulfoxide (20 mL) was added N,N-diisopropylethylamine (5 mL). The mixture was stirred at 120° C. overnight. The mixture was diluted with ethyl acetate (300 mL) and washed with water (3×) brine and dried over Na2SO4. After filtration and evaporation of the solvent, the residue was loaded on a column and eluted with 40% ethyl acetate in hexane to give the title compound. washed with water (3×) brine dried over Na2SO4 After filtration and evaporation of the solvent eluted with 40% ethyl acetate in hexane
Source ID: ord-8cac9bae68ad4633939b1532b1265d05Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: The title compound was prepared according to the procedure described in step 1 of Example 42 from phenyl 2-(4-{4-[3-(aminocarbonyl)phenyl]-3,5-dimethyl-1H-pyrazol-1-yl}phenyl)ethylcarbamate (step 6 of example 72) and 2,4-difluorobenzensulfonamide: MS (ESI) m/z 554 [M+H]+, 552 [M−H]−, 1H-NMR (CDCl3) δ 8.00-7.98 (1H, m), 7.83-7.73 (3H, m), 7.56-7.44 (2H, m), 7.22 (4H, s), 7.05-6.94 (1H, m), 6.20 (1H, br.s), 5.66 (1H, br.s), 3.47 (2H, t, J=6.2 Hz), 2.85 (2H, t, J=6.2 Hz), 2.21 (3H, s), 2.20 (3H, s).
Source ID: ord-5ab8beeca5c847d088a3e041baf66788Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: The title compound was prepared according to the procedure described in step 1 of Example 42 from phenyl 2-(4-{4-[3-(aminocarbonyl)phenyl]-3,5-dimethyl-1H-pyrazol-1-yl}phenyl)ethylcarbamate (step 6 of example 72) and 2,4-difluorobenzensulfonamide: MS (ESI) m/z 554 [M+H]+, 552 [M−H]−, 1H-NMR (CDCl3) δ 8.00-7.98 (1H, m), 7.83-7.73 (3H, m), 7.56-7.44 (2H, m), 7.22 (4H, s), 7.05-6.94 (1H, m), 6.20 (1H, br.s), 5.66 (1H, br.s), 3.47 (2H, t, J=6.2 Hz), 2.85 (2H, t, J=6.2 Hz), 2.21 (3H, s), 2.20 (3H, s).
Source ID: ord-5ab8beeca5c847d088a3e041baf66788Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: The title compound was prepared according to the procedure described in step 1 of Example 42 from phenyl 2-[4-(3,5-dimethyl-4-phenyl-1H-pyrazol-1-yl)phenyl]ethylcarbamate (step 1 of Example 22) and 2,4-difluorobenzenesulfonamide: 1H-NMR (CDCl3) δ 7.98-7.90 (1H, m), 7.47-7.41 (2H, m), 7.35-7.22 (7H, m), 7.07-6.92 (2H, m), 6.16 (1H, br.s), 3.50-3.43 (2H, m), 2.84 (2H, t, J=6.6 Hz), 2.33 (3H, s), 2.23 (3H, s).
Source ID: ord-4daed609f4064dcb91ffb0ecec291147Conditions: temp:120.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To a solution of 2,4-difluorobenzenesulfonamide (1.56 g) and 1-((4′-chlorobiphenyl-2-yl)methyl)piperazine (2.32 g) in dimethylsulfoxide (20 mL) was added N,N-diisopropylethylamine (5 mL). The mixture was stirred at 120° C. overnight. The mixture was diluted with ethyl acetate (300 mL) and washed with water (3×) brine and dried over Na2SO4. After filtration and evaporation of the solvent, the residue was loaded on a column and eluted with 40% ethyl acetate in hexane to give the title compound. washed with water (3×) brine dried over Na2SO4 After filtration and evaporation of the solvent eluted with 40% ethyl acetate in hexane
Source ID: ord-c4da5895f7504bc5a6f5ece6a70ad6a4Conditions: temp:120.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To a solution of 2,4-difluorobenzenesulfonamide (1.56 g) and 1-((4′-chlorobiphenyl-2-yl)methyl)piperazine (2.32 g) in dimethylsulfoxide (20 mL) was added N,N-diisopropylethylamine (5 mL). The mixture was stirred at 120° C. overnight. The mixture was diluted with ethyl acetate (300 mL) and washed with water (3×) brine and dried over Na2SO4. After filtration and evaporation of the solvent, the residue was loaded on a column and eluted with 40% ethyl acetate in hexane to give the title compound. washed with water (3×) brine dried over Na2SO4 After filtration and evaporation of the solvent eluted with 40% ethyl acetate in hexane
Source ID: ord-c4da5895f7504bc5a6f5ece6a70ad6a4Conditions: temp:120.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To a solution of 2,4-difluorobenzenesulfonamide (1.56 g) and 1-((4′-chlorobiphenyl-2-yl)methyl)piperazine (2.32 g) in dimethylsulfoxide (20 mL) was added N,N-diisopropylethylamine (5 mL). The mixture was stirred at 120° C. overnight. The mixture was diluted with ethyl acetate (300 mL) and washed with water (3×) brine and dried over Na2SO4. After filtration and evaporation of the solvent, the residue was loaded on a column and eluted with 40% ethyl acetate in hexane to give the title compound. washed with water (3×) brine dried over Na2SO4 After filtration and evaporation of the solvent eluted with 40% ethyl acetate in hexane
Source ID: ord-31e6bfefcef94dfead04a0b89ae7da3cConditions: temp:120.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To a solution of 2,4-difluorobenzenesulfonamide (1.56 g) and 1-((4′-chlorobiphenyl-2-yl)methyl)piperazine (2.32 g) in dimethylsulfoxide (20 mL) was added N,N-diisopropylethylamine (5 mL). The mixture was stirred at 120° C. overnight. The mixture was diluted with ethyl acetate (300 mL) and washed with water (3×) brine and dried over Na2SO4. After filtration and evaporation of the solvent, the residue was loaded on a column and eluted with 40% ethyl acetate in hexane to give the title compound. washed with water (3×) brine dried over Na2SO4 After filtration and evaporation of the solvent eluted with 40% ethyl acetate in hexane
Source ID: ord-31e6bfefcef94dfead04a0b89ae7da3cConditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-c1b21ea7f6474ef8ab31205de8a1ccf1Conditions: temp:120.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To a solution of 2,4-difluorobenzenesulfonamide (1.56 g) and 1-((4′-chlorobiphenyl-2-yl)methyl)piperazine (2.32 g) in dimethylsulfoxide (20 mL) was added N,N-diisopropylethylamine (5 mL). The mixture was stirred at 120° C. overnight. The mixture was diluted with ethyl acetate (300 mL) and washed with water (3×) brine and dried over Na2SO4. After filtration and evaporation of the solvent, the residue was loaded on a column and eluted with 40% ethyl acetate in hexane to give the title compound. washed with water (3×) brine dried over Na2SO4 After filtration and evaporation of the solvent eluted with 40% ethyl acetate in hexane
Source ID: ord-e5d21e09030749808107654fc1c1f91aConditions: temp:120.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To a solution of 2,4-difluorobenzenesulfonamide (1.56 g) and 1-((4′-chlorobiphenyl-2-yl)methyl)piperazine (2.32 g) in dimethylsulfoxide (20 mL) was added N,N-diisopropylethylamine (5 mL). The mixture was stirred at 120° C. overnight. The mixture was diluted with ethyl acetate (300 mL) and washed with water (3×) brine and dried over Na2SO4. After filtration and evaporation of the solvent, the residue was loaded on a column and eluted with 40% ethyl acetate in hexane to give the title compound. washed with water (3×) brine dried over Na2SO4 After filtration and evaporation of the solvent eluted with 40% ethyl acetate in hexane
Source ID: ord-8cac9bae68ad4633939b1532b1265d05PubChem References
These sources are listed in the compound's public database record.
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