ethyl 3-fluoro-2-oxopiperidine-3-carboxylate

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: Samples were prepared in batches according to the following method: ethyl-3-fluoro-2-oxo-3-piperidinecarboxylate (25 g) was dissolved in ethanol (450 ml) with gentle heating and sonication. The solution was then filtered through a Pall Acrodisc 37 mm syringe filter with 1 μm glass fibre membrane to remove fines and undissolved material. The filtered solution was adjusted to a total volume of 500 ml with ethanol to give a solution with nominal concentration of 50 mg/mL. Samples were prepared in batches with gentle heating sonication The solution was then filtered through a Pall Acrodisc 37 mm syringe filter with 1 μm glass fibre membrane to remove fines and undissolved material to give a solution with nominal concentration of 50 mg/mL

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: Samples were prepared in batches according to the following method: ethyl-3-fluoro-2-oxo-3-piperidinecarboxylate (25 g) was dissolved in ethanol (450 ml) with gentle heating and sonication. The solution was then filtered through a Pall Acrodisc 37 mm syringe filter with 1 μm glass fibre membrane to remove fines and undissolved material. The filtered solution was adjusted to a total volume of 500 ml with ethanol to give a solution with nominal concentration of 50 mg/mL. Samples were prepared in batches with gentle heating sonication The solution was then filtered through a Pall Acrodisc 37 mm syringe filter with 1 μm glass fibre membrane to remove fines and undissolved material to give a solution with nominal concentration of 50 mg/mL

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: Samples were prepared in batches according to the following method: ethyl-3-fluoro-2-oxo-3-piperidinecarboxylate (25 g) was dissolved in ethanol (450 ml) with gentle heating and sonication. The solution was then filtered through a Pall Acrodisc 37 mm syringe filter with 1 μm glass fibre membrane to remove fines and undissolved material. The filtered solution was adjusted to a total volume of 500 ml with ethanol to give a solution with nominal concentration of 50 mg/mL. Samples were prepared in batches with gentle heating sonication The solution was then filtered through a Pall Acrodisc 37 mm syringe filter with 1 μm glass fibre membrane to remove fines and undissolved material to give a solution with nominal concentration of 50 mg/mL