1-(phenylmethoxymethyl)cyclopropane-1-sulfonyl chloride

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: Using the same reaction conditions and workup as described for the preparation of Example 19A, 8-amino-7-(2-fluoro-4-iodo-phenylamino)-6-methyl-2,3-dihydro-thiazolo[3,2-a]pyridin-5-one (I-19f: 0.2 g, 0.048 mmol) in pyridine (2 mL) was reacted with 1-benzyloxymethyl-cyclopropanesulfonyl chloride (137 mg, 0.52 mmol) to afford the crude product. Purification by column chromatography on silica gel (50% ethylacetate in hexane) afforded 0.21 g of the product (70% yield). the same reaction conditions and workup to afford the crude product Purification by column chromatography on silica gel (50% ethylacetate in hexane)

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: Using the same reaction conditions and workup as described for the preparation of Example 7A, 8-amino-7-(2-fluoro-4-iodo-phenylamino)-6-methyl-2,3-dihydro-oxazolo[3,2-a]pyridin-5-one (I-7f: 0.35 g, 0.873 mmol) in pyridine (3 mL) was reacted with 1-benzyloxymethyl-cyclopropanesulfonyl chloride (0.34 mg, 1.30 mmol) to afford the crude product. Purification by column chromatography on silica gel (2% MeOH in CHCl3) afforded 0.27 g of the product (50% yield). the same reaction conditions and workup to afford the crude product Purification by column chromatography on silica gel (2% MeOH in CHCl3)