2-bromo-6-propan-2-ylphenol

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: 198.1 ml (3.85 mol) of bromine were added dropwise at -5° to 0° to a solution of 470 g of sodium hydroxide in 2 l of water. The mixture was stirred at this temperature for a further 10 min. The resulting sodium hypobromite solution was added dropwise at -5° to 0° C. to a solution of 464 g of a 40% strength aqueous dimethylamine solution (4.11 mol) in 50 ml of water. The mixture was stirred for a further 30 min, then the organic phase was separated off and the aqueous phase was extracted twice using 750 ml portions of methylene chloride. The combined organic phases were briefly dried over magnesium sulfate and filtered. The filtrate was added dropwise at -10° C. to a solution of 500 g (3.67 mol) of ortho-isopropylphenol in 900 ml of methylene chloride. After addition of about 2/3 of the filtrate, a solid formed and the reaction mixture became viscous and difficult to stir. 500 ml of methylene chloride were added at -10° C. and the mixture was stirred for a further hour. The solid was filtered off with suction, washed with a little cold methylene chloride, suspended in 1.5 l of 2N sulfuric acid and stirred at room temperature until all the solid had changed to an oil. The organic phase was separated off and the aqueous phase was extracted with methylene chloride. The combined organic phases were washed with sodium chloride solution and dried, end the solvent was removed in vacuo. The residue was distilled through a 30 cm Vigreux column in a water jet vacuum. The mixture was stirred for a further 30 min the organic phase was separated off the aqueous phase was extracted twice The combined organic phases were briefly dried over magnesium sulfate filtered After addition of about 2/3 of the filtrate a solid formed difficult to stir the mixture was stirred for a further hour The solid was filtered off with suction washed with a little cold methylene chloride stirred at room temperature until all the solid The organic phase was separated off the aqueous phase was extracted with methylene chloride The combined organic phases were washed with sodium chloride solution dried was removed in vacuo The residue was distilled through a 30 cm Vigreux column in a water jet vacuum

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: 198.1 ml (3.85 mol) of bromine were added dropwise at -5° to 0° to a solution of 470 g of sodium hydroxide in 2 l of water. The mixture was stirred at this temperature for a further 10 min. The resulting sodium hypobromite solution was added dropwise at -5° to 0° C. to a solution of 464 g of a 40% strength aqueous dimethylamine solution (4.11 mol) in 50 ml of water. The mixture was stirred for a further 30 min, then the organic phase was separated off and the aqueous phase was extracted twice using 750 ml portions of methylene chloride. The combined organic phases were briefly dried over magnesium sulfate and filtered. The filtrate was added dropwise at -10° C. to a solution of 500 g (3.67 mol) of ortho-isopropylphenol in 900 ml of methylene chloride. After addition of about 2/3 of the filtrate, a solid formed and the reaction mixture became viscous and difficult to stir. 500 ml of methylene chloride were added at -10° C. and the mixture was stirred for a further hour. The solid was filtered off with suction, washed with a little cold methylene chloride, suspended in 1.5 l of 2N sulfuric acid and stirred at room temperature until all the solid had changed to an oil. The organic phase was separated off and the aqueous phase was extracted with methylene chloride. The combined organic phases were washed with sodium chloride solution and dried, end the solvent was removed in vacuo. The residue was distilled through a 30 cm Vigreux column in a water jet vacuum. The mixture was stirred for a further 30 min the organic phase was separated off the aqueous phase was extracted twice The combined organic phases were briefly dried over magnesium sulfate filtered After addition of about 2/3 of the filtrate a solid formed difficult to stir the mixture was stirred for a further hour The solid was filtered off with suction washed with a little cold methylene chloride stirred at room temperature until all the solid The organic phase was separated off the aqueous phase was extracted with methylene chloride The combined organic phases were washed with sodium chloride solution dried was removed in vacuo The residue was distilled through a 30 cm Vigreux column in a water jet vacuum

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: 6-Bromo-2-isopropylphenol, made as described in Example 2, was reacted with CF3CF2COONa in the presence of CuI (Freskos J N, Synth Comm 18:965-972, 1988). This reaction resulted in the synthesis of 6-pentafluoroethyl-2-isopropylphenol.

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: 6-Bromo-2-isopropylphenol, made as described in Example 2, was reacted with CF3CF2COONa in the presence of CuI (Freskos J N, Synth Comm 18:965-972, 1988). This reaction resulted in the synthesis of 6-pentafluoroethyl-2-isopropylphenol.

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: 198.1 ml (3.85 mol) of bromine were added dropwise at -5° to 0° C. to a solution of 470 g of sodium hydroxide in 2 l of water. The mixture was stirred at this temperature for a further 10 min. The resulting sodium hypobromite solution was added dropwise at -5° to 0° C. to a solution of 464 g of a 40% strength aqueous dimethylamine solution (4.11 mol) in 50 ml of water. The mixture was stirred for a further 30 min, the organic phase was then separated off and the aqueous phase was extracted twice using 750 ml of methylene chloride each time. The combined organic phases were dried briefly over magnesium sulfate and filtered. The filtrate was added dropwise at -10° C. to a solution of 500 g (3.67 mol) of ortho-isopropylphenol in 900 ml of methylene chloride. After adding about 2/3 of the filtrate, a solid formed and the reaction mixture became viscous and could only be stirred with difficulty. 500 ml of methylene chloride were added at -10° C. and the mixture was stirred for a further hour. The solid was filtered off with suction, washed with a little cold methylene chloride, suspended in 1.5 1 of 2N sulfuric acid and stirred at room temperature until all the solid had been converted into an oil. The organic phase was separated off, and the aqueous phase was extracted using methylene chloride. The combined organic phases were washed with sodium chloride solution and dried, and the solvent was removed in vacuo. The residue was distilled through a 30 cm Vigreux column in a water jet vacuum. The mixture was stirred for a further 30 min the organic phase was then separated off the aqueous phase was extracted twice The combined organic phases were dried briefly over magnesium sulfate filtered After adding about 2/3 of the filtrate a solid formed could only be stirred with difficulty the mixture was stirred for a further hour The solid was filtered off with suction washed with a little cold methylene chloride stirred at room temperature until all the solid The organic phase was separated off the aqueous phase was extracted The combined organic phases were washed with sodium chloride solution dried the solvent was removed in vacuo The residue was distilled through a 30 cm Vigreux column in a water jet vacuum

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: 198.1 ml (3.85 mol) of bromine were added dropwise at -5° to 0° to a solution of 470 g of sodium hydroxide in 2 l of water. The mixture was stirred at this temperature for a further 10 min. The resulting sodium hypobromite solution was added dropwise at -5° to 0° C. to a solution of 464 g of a 40% strength aqueous dimethylamine solution (4.11 mol) in 50 ml of water. The mixture was stirred for a further 30 min, then the organic phase was separated off and the aqueous phase was extracted twice using 750 ml portions of methylene chloride. The combined organic phases were briefly dried over magnesium sulfate and filtered. The filtrate was added dropwise at -10° C. to a solution of 500 g (3.67 mol) of ortho-isopropylphenol in 900 ml of methylene chloride. After addition of about 2/3 of the filtrate, a solid formed and the reaction mixture became viscous and difficult to stir. 500 ml of methylene chloride were added at -10° C. and the mixture was stirred for a further hour. The solid was filtered off with suction, washed with a little cold methylene chloride, suspended in 1.5 l of 2N sulfuric acid and stirred at room temperature until all the solid had changed to an oil. The organic phase was separated off and the aqueous phase was extracted with methylene chloride. The combined organic phases were washed with sodium chloride solution and dried, end the solvent was removed in vacuo. The residue was distilled through a 30 cm Vigreux column in a water jet vacuum. The mixture was stirred for a further 30 min the organic phase was separated off the aqueous phase was extracted twice The combined organic phases were briefly dried over magnesium sulfate filtered After addition of about 2/3 of the filtrate a solid formed difficult to stir the mixture was stirred for a further hour The solid was filtered off with suction washed with a little cold methylene chloride stirred at room temperature until all the solid The organic phase was separated off the aqueous phase was extracted with methylene chloride The combined organic phases were washed with sodium chloride solution dried was removed in vacuo The residue was distilled through a 30 cm Vigreux column in a water jet vacuum

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: 198.1 ml (3.85 mol) of bromine were added dropwise at -5° to 0° C. to a solution of 470 g of sodium hydroxide in 2 l of water. The mixture was stirred at this temperature for a further 10 min, The resulting sodium hypobromite solution was added dropwise at -5° to 0° C. to a solution of 464 g of a 40% strength aqueous dimethylamine solution (4.11 mol) in 50 ml of water. The mixture was stirred for a further 30 min, then the organic phase was separated off and the aqueous phase was extracted twice using 750 ml portions of methylene chloride, The combined organic phases were briefly dried over magnesium sulfate and filtered, The filtrate was added dropwise at -10° C. to a solution of 500 g (3.67 mol) of ortho-isopropylphenol in 900 ml of methylene chloride. After addition of about 2/3 of the filtrate, a solid formed and the reaction mixture became viscous and difficult to stir. 500 ml of methylene chloride were added at -10° C. and the mixture was stirred for a further hour. The solid was filtered off with suction, washed with a little cold methylene chloride, suspended in 1.5 1 of 2N sulfuric acid and stirred at room temperature until all the solid had changed to an oil. The organic phase was separated off and the aqueous phase was extracted with methylene chloride. The combined organic phases were washed with sodium chloride solution and dried, and the solvent was removed in vacuo. The residue was distilled through a 30 cm Vigreux column in a water Jet vacuum. The mixture was stirred for a further 30 min the organic phase was separated off the aqueous phase was extracted twice The combined organic phases were briefly dried over magnesium sulfate filtered After addition of about 2/3 of the filtrate a solid formed difficult to stir the mixture was stirred for a further hour The solid was filtered off with suction washed with a little cold methylene chloride stirred at room temperature until all the solid The organic phase was separated off the aqueous phase was extracted with methylene chloride The combined organic phases were washed with sodium chloride solution dried the solvent was removed in vacuo The residue was distilled through a 30 cm Vigreux column in a water Jet vacuum

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: 198.1 ml (3.85 mol) of bromine were added dropwise at -5° to 0° C. to a solution of 470 g of sodium hydroxide in 2 l of water. The mixture was stirred at this temperature for a further 10 min, The resulting sodium hypobromite solution was added dropwise at -5° to 0° C. to a solution of 464 g of a 40% strength aqueous dimethylamine solution (4.11 mol) in 50 ml of water. The mixture was stirred for a further 30 min, then the organic phase was separated off and the aqueous phase was extracted twice using 750 ml portions of methylene chloride, The combined organic phases were briefly dried over magnesium sulfate and filtered, The filtrate was added dropwise at -10° C. to a solution of 500 g (3.67 mol) of ortho-isopropylphenol in 900 ml of methylene chloride. After addition of about 2/3 of the filtrate, a solid formed and the reaction mixture became viscous and difficult to stir. 500 ml of methylene chloride were added at -10° C. and the mixture was stirred for a further hour. The solid was filtered off with suction, washed with a little cold methylene chloride, suspended in 1.5 1 of 2N sulfuric acid and stirred at room temperature until all the solid had changed to an oil. The organic phase was separated off and the aqueous phase was extracted with methylene chloride. The combined organic phases were washed with sodium chloride solution and dried, and the solvent was removed in vacuo. The residue was distilled through a 30 cm Vigreux column in a water Jet vacuum. The mixture was stirred for a further 30 min the organic phase was separated off the aqueous phase was extracted twice The combined organic phases were briefly dried over magnesium sulfate filtered After addition of about 2/3 of the filtrate a solid formed difficult to stir the mixture was stirred for a further hour The solid was filtered off with suction washed with a little cold methylene chloride stirred at room temperature until all the solid The organic phase was separated off the aqueous phase was extracted with methylene chloride The combined organic phases were washed with sodium chloride solution dried the solvent was removed in vacuo The residue was distilled through a 30 cm Vigreux column in a water Jet vacuum

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: 198.1 ml (3.85 mol) of bromine were added dropwise at -5° to 0° C. to a solution of 470 g of sodium hydroxide in 2 l of water. The mixture was stirred at this temperature for a further 10 min. The resulting sodium hypobromite solution was added dropwise at -5° to 0° C. to a solution of 464 g of a 40% strength aqueous dimethylamine solution (4.11 mol) in 50 ml of water. The mixture was stirred for a further 30 min, then the organic phase was separated off and the aqueous phase was extracted twice using 750 ml portions of methylene chloride. The combined organic phases were briefly dried over magnesium sulfate and filtered. The filtrate was added dropwise at -10° C. to a solution of 500 g (3.67 mol) of ortho-isopropylphenol in 900 ml of methylene chloride. After addition of about 2/3 of the filtrate, a solid formed and the reaction mixture became viscous and difficult to stir. 500 ml of methylene chloride were added at -10° C. and the mixture was stirred for a further hour. The solid was filtered off with suction, washed with a little cold methylene chloride, suspended in 1.5 l of 2N sulfuric acid and stirred at room temperature until all the solid had changed to an oil. The organic phase was separated off and the aqueous phase was extracted with methylene chloride. The combined organic phases were washed with sodium chloride solution and dried, and the solvent was removed in vacuo. The residue was distilled through a 30 cm Vigreux column in a water jet vacuum. The mixture was stirred for a further 30 min the organic phase was separated off the aqueous phase was extracted twice The combined organic phases were briefly dried over magnesium sulfate filtered After addition of about 2/3 of the filtrate a solid formed difficult to stir the mixture was stirred for a further hour The solid was filtered off with suction washed with a little cold methylene chloride stirred at room temperature until all the solid The organic phase was separated off the aqueous phase was extracted with methylene chloride The combined organic phases were washed with sodium chloride solution dried the solvent was removed in vacuo The residue was distilled through a 30 cm Vigreux column in a water jet vacuum

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: 6-Bromo-2-isopropylphenol, made as described in Example 2, was reacted with CF3CF2COONa in the presence of CuI (Freskos J N, Synth Comm 18:965-972, 1988). This reaction resulted in the synthesis of 6-pentafluoroethyl-2-isopropylphenol.

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: 198.1 ml (3.85 mol) of bromine were added dropwise at -5° to 0° C. to a solution of 470 g of sodium hydroxide in 2 l of water. The mixture was stirred at this temperature for a further 10 min. The resulting sodium hypobromite solution was added dropwise at -5° to 0° C. to a solution of 464 g of a 40% strength aqueous dimethylamine solution (4.11 mol) in 50 ml of water. The mixture was stirred for a further 30 min, the organic phase was then separated off and the aqueous phase was extracted twice using 750 ml of methylene chloride each time. The combined organic phases were dried briefly over magnesium sulfate and filtered. The filtrate was added dropwise at -10° C. to a solution of 500 g (3.67 mol) of ortho-isopropylphenol in 900 ml of methylene chloride. After adding about 2/3 of the filtrate, a solid formed and the reaction mixture became viscous and could only be stirred with difficulty. 500 ml of methylene chloride were added at -10° C. and the mixture was stirred for a further hour. The solid was filtered off with suction, washed with a little cold methylene chloride, suspended in 1.5 1 of 2N sulfuric acid and stirred at room temperature until all the solid had been converted into an oil. The organic phase was separated off, and the aqueous phase was extracted using methylene chloride. The combined organic phases were washed with sodium chloride solution and dried, and the solvent was removed in vacuo. The residue was distilled through a 30 cm Vigreux column in a water jet vacuum. The mixture was stirred for a further 30 min the organic phase was then separated off the aqueous phase was extracted twice The combined organic phases were dried briefly over magnesium sulfate filtered After adding about 2/3 of the filtrate a solid formed could only be stirred with difficulty the mixture was stirred for a further hour The solid was filtered off with suction washed with a little cold methylene chloride stirred at room temperature until all the solid The organic phase was separated off the aqueous phase was extracted The combined organic phases were washed with sodium chloride solution dried the solvent was removed in vacuo The residue was distilled through a 30 cm Vigreux column in a water jet vacuum

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: 198.1 ml (3.85 mol) of bromine were added dropwise at -5° to 0° to a solution of 470 g of sodium hydroxide in 2 l of water. The mixture was stirred at this temperature for a further 10 min. The resulting sodium hypobromite solution was added dropwise at -5° to 0° C. to a solution of 464 g of a 40% strength aqueous dimethylamine solution (4.11 mol) in 50 ml of water. The mixture was stirred for a further 30 min, then the organic phase was separated off and the aqueous phase was extracted twice using 750 ml portions of methylene chloride. The combined organic phases were briefly dried over magnesium sulfate and filtered. The filtrate was added dropwise at -10° C. to a solution of 500 g (3.67 mol) of ortho-isopropylphenol in 900 ml of methylene chloride. After addition of about 2/3 of the filtrate, a solid formed and the reaction mixture became viscous and difficult to stir. 500 ml of methylene chloride were added at -10° C. and the mixture was stirred for a further hour. The solid was filtered off with suction, washed with a little cold methylene chloride, suspended in 1.5 l of 2N sulfuric acid and stirred at room temperature until all the solid had changed to an oil. The organic phase was separated off and the aqueous phase was extracted with methylene chloride. The combined organic phases were washed with sodium chloride solution and dried, end the solvent was removed in vacuo. The residue was distilled through a 30 cm Vigreux column in a water jet vacuum. The mixture was stirred for a further 30 min the organic phase was separated off the aqueous phase was extracted twice The combined organic phases were briefly dried over magnesium sulfate filtered After addition of about 2/3 of the filtrate a solid formed difficult to stir the mixture was stirred for a further hour The solid was filtered off with suction washed with a little cold methylene chloride stirred at room temperature until all the solid The organic phase was separated off the aqueous phase was extracted with methylene chloride The combined organic phases were washed with sodium chloride solution dried was removed in vacuo The residue was distilled through a 30 cm Vigreux column in a water jet vacuum