2-(3-methylbutyl)-2-propan-2-ylpropane-1,3-diol

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: To 7.5 g (0.04 mol) 2-isoamyl-2-isopropyl-1,3-propandiol, which was prepared according to the process described in synthetic example 63, was added 50 ml tetrahydrofuran, then added 9.7 ml (0.12 mol) pyridine with stirring. To the resulting homogenous mixture was slowly added 16.7 g(0.1 mol) cinnamoyl chloride. The mixture was stirred at room temperature for 1 hour, and heated refluxing for 4 hours. Upon completing the reaction, 50 ml water was added to dissolve the resulting salt. The mixture was extracted with ethyl acetate. The organic phase was separated, washed with saturated saline for two times, and dried over anhydrous sodium sulfate. The solvent was removed. Column chromatography gave 2-isoamyl-2-isopropyl-1,3-propandiol dicinnamate as a yellow viacous liquid, and the yield was 51%. 1HNMR: δ (ppm) 0.88(d, 6H, CH3 of isoamyl), 0.99(d, 6H, CH3 of isopropyl), 1.21(m, 2H, CH2 of isoamy), 1.47(m, 2H, CH2 of isoamyl), 1.51(m, 1H, CH of isoamyl), 1.96(m, 1H, CH of isopropyl), 4.26(m, 4H, CH2O of 1,3-propandiol), 6.45(d, 2H, CH linked to carbonyl), 7.26-7.70(m, 12H, ArH and ═CH—) The mixture was stirred at room temperature for 1 hour heated refluxing for 4 hours was added to dissolve the resulting salt The mixture was extracted with ethyl acetate The organic phase was separated washed with saturated saline for two times dried over anhydrous sodium sulfate The solvent was removed

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: To 7.5 g (0.05 mol) 2-isoamyl-2-isopropyl-1,3-propandiol, which was prepared according to the process described in synthetic example 63, was added 50 ml tetrahydrofuran, then added 4.8 ml (0.06 mol) pyridine with stirring. To the resulting homogenous mixture was slowly added 4.6 ml (0.04 mol) benzoyl chloride. The mixture was stirred at room temperature for 1 hour and heated refluxing for 5 hours. Upon completing the reaction, the reaction mixture was cooled to room temperature. To the mixture was added 30 ml tetrahydrofuran, then added 4.8 ml (0.06 mol) pyridine with stirring. To the resulting homogenous mixture was slowly added 3.5 ml (0.04 mol) propionyl chloride. The mixture was stirred at room temperature for 1 hour, and heated refluxing for 5 hours. Upon completing the reaction, 40 ml water was added to dissolve the resulting salt. The mixture was extracted with ethyl acetate. The organic phase was separated, washed with saturated saline for two times, and dried over anhydrous sodium sulfate. The solvent was removed. Distillation under reduced pressure gave colorless liquid 2-isoamyl-2-isopropyl-1,3-propandiol monobenzoate monopropionate, and the yield was 91%. 1HNMR: δ (ppm) 0.87(d, 6H, CH3 of isoamyl), 0.93(d, 6H, CH3 of isopropyl), 0.99(t, 2H, CH3 of propionyl), 1.06(m, 4H, CH2 of isoamy), 1.11(m, 1H, CH of isoamyl), 1.14(m, 1H, CH of isopropyl), 2.29(m, 2H, CH2O of 1,3-propandiol), 4.28(m, 2H, CH2O of 1,3-propandiol), 4.38 (m, 2H, CH2 of propionyl), 7.41-8.03(m, 5H, ArH) The mixture was stirred at room temperature for 1 hour heated refluxing for 5 hours the reaction with stirring The mixture was stirred at room temperature for 1 hour heated refluxing for 5 hours was added to dissolve the resulting salt The mixture was extracted with ethyl acetate The organic phase was separated washed with saturated saline for two times dried over anhydrous sodium sulfate The solvent was removed Distillation under reduced pressure

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: To 7.5 g (0.04 mol) 2-isoamyl-2-isopropyl-1,3-propandiol, which was prepared according to the process described in synthetic example 63, was added 50 ml tetrahydrofuran, then added 9.7 ml (0.12 mol) pyridine with stirring. To the resulting homogenous mixture was slowly added 16.7 g(0.1 mol) cinnamoyl chloride. The mixture was stirred at room temperature for 1 hour, and heated refluxing for 4 hours. Upon completing the reaction, 50 ml water was added to dissolve the resulting salt. The mixture was extracted with ethyl acetate. The organic phase was separated, washed with saturated saline for two times, and dried over anhydrous sodium sulfate. The solvent was removed. Column chromatography gave 2-isoamyl-2-isopropyl-1,3-propandiol dicinnamate as a yellow viacous liquid, and the yield was 51%. 1HNMR: δ (ppm) 0.88(d, 6H, CH3 of isoamyl), 0.99(d, 6H, CH3 of isopropyl), 1.21(m, 2H, CH2 of isoamy), 1.47(m, 2H, CH2 of isoamyl), 1.51(m, 1H, CH of isoamyl), 1.96(m, 1H, CH of isopropyl), 4.26(m, 4H, CH2O of 1,3-propandiol), 6.45(d, 2H, CH linked to carbonyl), 7.26-7.70(m, 12H, ArH and ═CH—) The mixture was stirred at room temperature for 1 hour heated refluxing for 4 hours was added to dissolve the resulting salt The mixture was extracted with ethyl acetate The organic phase was separated washed with saturated saline for two times dried over anhydrous sodium sulfate The solvent was removed

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: To 7.5 g (0.05 mol) 2-isoamyl-2-isopropyl-1,3-propandiol, which was prepared according to the process described in synthetic example 63, was added 50 ml tetrahydrofuran, then added 4.8 ml (0.06 mol) pyridine with stirring. To the resulting homogenous mixture was slowly added 4.6 ml (0.04 mol) benzoyl chloride. The mixture was stirred at room temperature for 1 hour and heated refluxing for 5 hours. Upon completing the reaction, the reaction mixture was cooled to room temperature. To the mixture was added 30 ml tetrahydrofuran, then added 4.8 ml (0.06 mol) pyridine with stirring. To the resulting homogenous mixture was slowly added 3.5 ml (0.04 mol) propionyl chloride. The mixture was stirred at room temperature for 1 hour, and heated refluxing for 5 hours. Upon completing the reaction, 40 ml water was added to dissolve the resulting salt. The mixture was extracted with ethyl acetate. The organic phase was separated, washed with saturated saline for two times, and dried over anhydrous sodium sulfate. The solvent was removed. Distillation under reduced pressure gave colorless liquid 2-isoamyl-2-isopropyl-1,3-propandiol monobenzoate monopropionate, and the yield was 91%. 1HNMR: δ (ppm) 0.87(d, 6H, CH3 of isoamyl), 0.93(d, 6H, CH3 of isopropyl), 0.99(t, 2H, CH3 of propionyl), 1.06(m, 4H, CH2 of isoamy), 1.11(m, 1H, CH of isoamyl), 1.14(m, 1H, CH of isopropyl), 2.29(m, 2H, CH2O of 1,3-propandiol), 4.28(m, 2H, CH2O of 1,3-propandiol), 4.38 (m, 2H, CH2 of propionyl), 7.41-8.03(m, 5H, ArH) The mixture was stirred at room temperature for 1 hour heated refluxing for 5 hours the reaction with stirring The mixture was stirred at room temperature for 1 hour heated refluxing for 5 hours was added to dissolve the resulting salt The mixture was extracted with ethyl acetate The organic phase was separated washed with saturated saline for two times dried over anhydrous sodium sulfate The solvent was removed Distillation under reduced pressure

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: To 7.5 g (0.04 mol) 2-isoamyl-2-isopropyl-1,3-propandiol, which was prepared according to the process described in synthetic example 63, was added 50 ml tetrahydrofuran, then added 9.7 ml (0.12 mol) pyridine with stirring. To the resulting homogenous mixture was slowly added 16.7 g(0.1 mol) cinnamoyl chloride. The mixture was stirred at room temperature for 1 hour, and heated refluxing for 4 hours. Upon completing the reaction, 50 ml water was added to dissolve the resulting salt. The mixture was extracted with ethyl acetate. The organic phase was separated, washed with saturated saline for two times, and dried over anhydrous sodium sulfate. The solvent was removed. Column chromatography gave 2-isoamyl-2-isopropyl-1,3-propandiol dicinnamate as a yellow viacous liquid, and the yield was 51%. 1HNMR: δ (ppm) 0.88(d, 6H, CH3 of isoamyl), 0.99(d, 6H, CH3 of isopropyl), 1.21(m, 2H, CH2 of isoamy), 1.47(m, 2H, CH2 of isoamyl), 1.51(m, 1H, CH of isoamyl), 1.96(m, 1H, CH of isopropyl), 4.26(m, 4H, CH2O of 1,3-propandiol), 6.45(d, 2H, CH linked to carbonyl), 7.26-7.70(m, 12H, ArH and ═CH—) The mixture was stirred at room temperature for 1 hour heated refluxing for 4 hours was added to dissolve the resulting salt The mixture was extracted with ethyl acetate The organic phase was separated washed with saturated saline for two times dried over anhydrous sodium sulfate The solvent was removed

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: To 7.5 g (0.05 mol) 2-isoamyl-2-isopropyl-1,3-propandiol, which was prepared according to the process described in synthetic example 63, was added 50 ml tetrahydrofuran, then added 4.8 ml (0.06 mol) pyridine with stirring. To the resulting homogenous mixture was slowly added 4.6 ml (0.04 mol) benzoyl chloride. The mixture was stirred at room temperature for 1 hour and heated refluxing for 5 hours. Upon completing the reaction, the reaction mixture was cooled to room temperature. To the mixture was added 30 ml tetrahydrofuran, then added 4.8 ml (0.06 mol) pyridine with stirring. To the resulting homogenous mixture was slowly added 3.5 ml (0.04 mol) propionyl chloride. The mixture was stirred at room temperature for 1 hour, and heated refluxing for 5 hours. Upon completing the reaction, 40 ml water was added to dissolve the resulting salt. The mixture was extracted with ethyl acetate. The organic phase was separated, washed with saturated saline for two times, and dried over anhydrous sodium sulfate. The solvent was removed. Distillation under reduced pressure gave colorless liquid 2-isoamyl-2-isopropyl-1,3-propandiol monobenzoate monopropionate, and the yield was 91%. 1HNMR: δ (ppm) 0.87(d, 6H, CH3 of isoamyl), 0.93(d, 6H, CH3 of isopropyl), 0.99(t, 2H, CH3 of propionyl), 1.06(m, 4H, CH2 of isoamy), 1.11(m, 1H, CH of isoamyl), 1.14(m, 1H, CH of isopropyl), 2.29(m, 2H, CH2O of 1,3-propandiol), 4.28(m, 2H, CH2O of 1,3-propandiol), 4.38 (m, 2H, CH2 of propionyl), 7.41-8.03(m, 5H, ArH) The mixture was stirred at room temperature for 1 hour heated refluxing for 5 hours the reaction with stirring The mixture was stirred at room temperature for 1 hour heated refluxing for 5 hours was added to dissolve the resulting salt The mixture was extracted with ethyl acetate The organic phase was separated washed with saturated saline for two times dried over anhydrous sodium sulfate The solvent was removed Distillation under reduced pressure