ethyl 3-(2,4-difluoroanilino)-2-methyl-3-oxopropanoate

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: The acid was prepared according to Procedure B using ethyl 3-(2,4-difluorophenylamino)-2-methyl-3-oxopropanoate (5.1 g, 19.83 mmol) in THF (19.8 mL) to give 3-(2,4-difluorophenylamino)-2-methyl-3-oxopropanoic acid. Mass Spectrum (ESI) m/e=230.1 (M+1). The acid was prepared

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: The ester was prepared according to Procedure A using diethyl 2-methylmalonate (5.99 mL, 34.9 mmol), pyridine (3.76 mL, 46.5 mmol) and 2,4-difluoroaniline (2.34 mL, 23.2 mmol). The residue was purified by column chromatography on silica gel (0-30% EtOAc/hexanes) to give ethyl 3-(2,4-difluorophenylamino)-2-methyl-3-oxopropanoate as a red oil. Mass Spectrum (ESI) m/e=258.1 (M+1). The ester was prepared The residue was purified by column chromatography on silica gel (0-30% EtOAc/hexanes)