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CCCCOC1=CC(=CC(=C1)F)FChemical Intermediate
Structures, identifiers and computed properties have been matched to the database record by CAS.
| Intermediates | 1-butoxy-3,5-difluorobenzene |
|---|---|
| IUPAC Name | — |
| CAS Number | 123843-64-1 |
| Database ID | 19010183 |
| Molecular Formula | — |
| Molecular Weight | — |
Product Information
1-butoxy-3,5-difluorobenzene (CAS 123843-64-1) product identity, structure identifiers and related reaction data for chemical intermediate research and sourcing review.
Potential Applications
For professional research and industrial use only
Database ID 19010183
Safety Notice
For professional research and industrial use only. Review the supplier safety data sheet before handling.
Synthesis data
8 reactions · 8 references
Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-92d5773a6f9341b083b36a5e534951bdConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A solution of n-butyllithium (10.5M in hexane; 3.60 ml, 0.038 mol) was added dropwise to a stirred, cooled (-78° C.) solution of compound 16 (7.00 g, 0.038 mol) in dry THF (35 ml) under dry nitrogen. The stirred mixture was maintained under these conditions for 2.5 h and then poured onto a slurry of solid carbon dioxide and dry ether. The product was extracted into 10% sodium hydroxide which was then acidified with 36% hydrochloric acid. The product was filtered off and dried (CaCl2) in vacuo to give a colourless solid. The stirred mixture was maintained under these conditions for 2.5 h The product was extracted into 10% sodium hydroxide which The product was filtered off dried (CaCl2) in vacuo to give a colourless solid
Source ID: ord-29507184b0814406ac19cfb9bafe6920Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A solution of n-butyllithium (10.5M in hexane; 3.60 ml, 0.038 mol) was added dropwise to a stirred, cooled (-78° C.) solution of compound 16 (7.00 g, 0.038 mol) in dry THF (35 ml) under dry nitrogen. The stirred mixture was maintained under these conditions for 2.5 h and then poured onto a slurry of solid carbon dioxide and dry ether. The product was extracted into 10% sodium hydroxide which was then acidified with 36% hydrochloric acid. The product was filtered off and dried (CaCl2) in vacuo to give a colourless solid. The stirred mixture was maintained under these conditions for 2.5 h The product was extracted into 10% sodium hydroxide which The product was filtered off dried (CaCl2) in vacuo to give a colourless solid
Source ID: ord-29507184b0814406ac19cfb9bafe6920Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A solution of 1-bromobutane (11.0 g, 0.08 mol) in acetone (30 ml) was added dropwise to a stirred, refluxing mixture of 3,5-difluorophenol (9.1 g, 0.07 mol) and potassium carbonate (30 g, 0.2 mol) in acetone (200 ml). The stirred mixture was heated under reflux for 24 h (glc analysis revealed absence of starting material). The product was extracted into ether (twice), and the combined ethereal extracts were washed with water, 5% sodium hydroxide, water and dried (MgSO4). Most of the solvent was removed in vacuo, and after the removal of the final amount of solvent and the excess of 1-bromobutane at atmospheric pressure, the residue was distilled to yield a colourless liquid. refluxing The stirred mixture was heated under reflux for 24 h (glc analysis revealed absence of starting material) The product was extracted into ether (twice), and the combined ethereal extracts were washed with water, 5% sodium hydroxide, water dried (MgSO4) Most of the solvent was removed in vacuo after the removal of the final amount of solvent the excess of 1-bromobutane at atmospheric pressure, the residue was distilled to yield a colourless liquid
Source ID: ord-330a52f4c11f4178a0cceb90945e1584Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-92d5773a6f9341b083b36a5e534951bdConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A solution of 1-bromobutane (11.0 g, 0.08 mol) in acetone (30 ml) was added dropwise to a stirred, refluxing mixture of 3,5-difluorophenol (9.1 g, 0.07 mol) and potassium carbonate (30 g, 0.2 mol) in acetone (200 ml). The stirred mixture was heated under reflux for 24 h (glc analysis revealed absence of starting material). The product was extracted into ether (twice), and the combined ethereal extracts were washed with water, 5% sodium hydroxide, water and dried (MgSO4). Most of the solvent was removed in vacuo, and after the removal of the final amount of solvent and the excess of 1-bromobutane at atmospheric pressure, the residue was distilled to yield a colourless liquid. refluxing The stirred mixture was heated under reflux for 24 h (glc analysis revealed absence of starting material) The product was extracted into ether (twice), and the combined ethereal extracts were washed with water, 5% sodium hydroxide, water dried (MgSO4) Most of the solvent was removed in vacuo after the removal of the final amount of solvent the excess of 1-bromobutane at atmospheric pressure, the residue was distilled to yield a colourless liquid
Source ID: ord-5f9c616dc41a4fbdab9a8ecbb9042829Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A solution of n-butyllithium (10.5M in hexane; 3.60 ml, 0.038 mol) was added dropwise to a stirred, cooled (-78° C.) solution of compound 16 (7.00 g, 0.038 mol) in dry THF (35 ml) under dry nitrogen. The stirred mixture was maintained under these conditions for 2.5 h and then poured onto a slurry of solid carbon dioxide and dry ether. The product was extracted into 10% sodium hydroxide which was then acidified with 36% hydrochloric acid. The product was filtered off and dried (CaCl2) in vacuo to give a colourless solid. The stirred mixture was maintained under these conditions for 2.5 h The product was extracted into 10% sodium hydroxide which The product was filtered off dried (CaCl2) in vacuo to give a colourless solid
Source ID: ord-29507184b0814406ac19cfb9bafe6920Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A solution of 1-bromobutane (11.0 g, 0.08 mol) in acetone (30 ml) was added dropwise to a stirred, refluxing mixture of 3,5-difluorophenol (9.1 g, 0.07 mol) and potassium carbonate (30 g, 0.2 mol) in acetone (200 ml). The stirred mixture was heated under reflux for 24 h (glc analysis revealed absence of starting material). The product was extracted into ether (twice), and the combined ethereal extracts were washed with water, 5% sodium hydroxide, water and dried (MgSO4). Most of the solvent was removed in vacuo, and after the removal of the final amount of solvent and the excess of 1-bromobutane at atmospheric pressure, the residue was distilled to yield a colourless liquid. refluxing The stirred mixture was heated under reflux for 24 h (glc analysis revealed absence of starting material) The product was extracted into ether (twice), and the combined ethereal extracts were washed with water, 5% sodium hydroxide, water dried (MgSO4) Most of the solvent was removed in vacuo after the removal of the final amount of solvent the excess of 1-bromobutane at atmospheric pressure, the residue was distilled to yield a colourless liquid
Source ID: ord-330a52f4c11f4178a0cceb90945e1584PubChem References
These sources are listed in the compound's public database record.
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