1-methoxy-2,2,6,6-tetramethylpiperidin-4-ol

Conditions: temp:0.00; pressure:0.00; stir:

Conditions: temp:0.00; pressure:0.00; stir:

Conditions: temp:0.00; pressure:0.00; stir:

Conditions: temp:0.00; pressure:0.00; stir:

Conditions: temp:0.00; pressure:0.00; stir:

Conditions: temp:0.00; pressure:0.00; stir:

Conditions: temp:0.00; pressure:0.00; stir:

Conditions: temp:0.00; pressure:0.00; stir:

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: The title compound is prepared by reacting 1-methoxy-2,2,6,6-tetramethylpiperidin-4-ol (1 mole) with methylchloroformate (1 mole).

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: The title compound is prepared by reacting 1-methoxy-2,2,6,6-tetramethyl-piperidin-4-ol (1 mole) with methylchloroformate (1 mole).

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: To a mixture of 15.8 g of 1-methoxy-2,2,6,6-tetramethylpiperidin-4-ol and 5.9 g of dimethyl hydrazine-1,2-dicarboxylate is added 1.4 g of tetrabutyl titanate at room temperature. The mixture is heated at 135°-145° C. for 12 hours and methanol is collected in a Dean-Stark trap. The reaction mixture is partitioned between toluene and water. The organic phase is then washed with water, brine, dried over anhydrous sodium sulfate and evaporated to leave 19.1 g of the crude desired product. Recrystallization of the crude product from acetonitrile affords 11.7 g of the title compound as an off-white solid; mp 147°-149° C. The mixture is heated at 135°-145° C. for 12 hours methanol is collected in a Dean-Stark trap The reaction mixture is partitioned between toluene and water The organic phase is then washed with water, brine dried over anhydrous sodium sulfate evaporated to leave 19.1 g of the crude desired product Recrystallization of the crude product from acetonitrile

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: 3-(5-Chlorobenzotriazol-2-yl)-5-tert-butyl-4-hydroxyhydrocinnamic acid (12.0 g, 0.032 mol) and 1-methoxy-2,2,6,6-tetramethyl-4-hydroxypiperidine (6.66 g, 0.036 mol) are reacted together according to the procedure given in Example 3. The title compound is obtained in a yield of 8.79 g (50.5%) as a light yellow solid, melting at 132-137° C., whose structure is consistent with 1Hnmr and mass spectrometry. The compound has a molar absorptivity of 17,210 l/mole cm.