No renderable structure data available
CC(C)(C)OC(=O)NCCCC(=O)C1=CC(=CC=C1)FChemical Intermediate
Structures, identifiers and computed properties have been matched to the database record by CAS.
| Intermediates | tert-butyl N-[4-(3-fluorophenyl)-4-oxobutyl]carbamate |
|---|---|
| IUPAC Name | — |
| CAS Number | 1223405-24-0 |
| Database ID | 67330612 |
| Molecular Formula | — |
| Molecular Weight | — |
Product Information
tert-butyl N-[4-(3-fluorophenyl)-4-oxobutyl]carbamate (CAS 1223405-24-0) product identity, structure identifiers and related reaction data for chemical intermediate research and sourcing review.
Potential Applications
For professional research and industrial use only
Database ID 67330612
Safety Notice
For professional research and industrial use only. Review the supplier safety data sheet before handling.
Synthesis data
10 reactions · 10 references
Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-c2bb3b693cfa415d9715dd4dcf232456Conditions: temp:-78.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: In a round-bottomed flask was charged tert-butyl 2-oxopyrrolidine-1-carboxylate (2.2 g, 11.9 mmol) and THF (25 mL). The mixture was cooled down to −78° C. first, followed by slow addition of (3-fluorophenyl)magnesium bromide (17.8 mL, 17.8 mmol, 1.0 M solution in THF) over 15 minutes. The mixture was stirred for 3 hours, during which time the bath temperature rose from −78° C. to −10° C. The reaction was quenched by drop-wise addition of 1N HCl (2 mL) and warmed up to ambient temperature, followed by addition of EtOAc and water. After separating the organic layer, the aqueous layer was extracted with EtOAc three times. The combined organic layers was dried over Na2SO4 and concentrated to yield the product as a clear oil. rose from −78° C. to −10° C The reaction was quenched by drop-wise addition of 1N HCl (2 mL) warmed up to ambient temperature followed by addition of EtOAc and water After separating the organic layer the aqueous layer was extracted with EtOAc three times The combined organic layers was dried over Na2SO4 concentrated
Source ID: ord-274f67140ff64dffb426ac3f96e73c7bConditions: temp:-78.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: In a round-bottomed flask was charged tert-butyl 2-oxopyrrolidine-1-carboxylate (2.2 g, 11.9 mmol) and THF (25 mL). The mixture was cooled down to −78° C. first, followed by slow addition of (3-fluorophenyl)magnesium bromide (17.8 mL, 17.8 mmol, 1.0 M solution in THF) over 15 minutes. The mixture was stirred for 3 hours, during which time the bath temperature rose from −78° C. to −10° C. The reaction was quenched by drop-wise addition of 1N HCl (2 mL) and warmed up to ambient temperature, followed by addition of EtOAc and water. After separating the organic layer, the aqueous layer was extracted with EtOAc three times. The combined organic layers was dried over Na2SO4 and concentrated to yield the product as a clear oil. rose from −78° C. to −10° C The reaction was quenched by drop-wise addition of 1N HCl (2 mL) warmed up to ambient temperature followed by addition of EtOAc and water After separating the organic layer the aqueous layer was extracted with EtOAc three times The combined organic layers was dried over Na2SO4 concentrated
Source ID: ord-274f67140ff64dffb426ac3f96e73c7bConditions: temp:-78.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: In a round-bottomed flask was charged tert-butyl 2-oxopyrrolidine-1-carboxylate (2.2 g, 11.9 mmol) and THF (25 mL). The mixture was cooled down to −78° C. first, followed by slow addition of (3-fluorophenyl)magnesium bromide (17.8 mL, 17.8 mmol, 1.0 M solution in THF) over 15 minutes. The mixture was stirred for 3 hours, during which time the bath temperature rose from −78° C. to −10° C. The reaction was quenched by drop-wise addition of 1N HCl (2 mL) and warmed up to ambient temperature, followed by addition of EtOAc and water. After separating the organic layer, the aqueous layer was extracted with EtOAc three times. The combined organic layers was dried over Na2SO4 and concentrated to yield the product as a clear oil. rose from −78° C. to −10° C The reaction was quenched by drop-wise addition of 1N HCl (2 mL) warmed up to ambient temperature followed by addition of EtOAc and water After separating the organic layer the aqueous layer was extracted with EtOAc three times The combined organic layers was dried over Na2SO4 concentrated
Source ID: ord-0e0d6802bbec4410b6ba92c729e66ce8Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-c2bb3b693cfa415d9715dd4dcf232456Conditions: temp:-78.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: In a round-bottomed flask was charged tert-butyl 2-oxopyrrolidine-1-carboxylate (2.2 g, 11.9 mmol) and THF (25 mL). The mixture was cooled down to −78° C. first, followed by slow addition of (3-fluorophenyl)magnesium bromide (17.8 mL, 17.8 mmol, 1.0 M solution in THF) over 15 minutes. The mixture was stirred for 3 hours, during which time the bath temperature rose from −78° C. to −10° C. The reaction was quenched by drop-wise addition of 1N HCl (2 mL) and warmed up to ambient temperature, followed by addition of EtOAc and water. After separating the organic layer, the aqueous layer was extracted with EtOAc three times. The combined organic layers was dried over Na2SO4 and concentrated to yield the product as a clear oil. rose from −78° C. to −10° C The reaction was quenched by drop-wise addition of 1N HCl (2 mL) warmed up to ambient temperature followed by addition of EtOAc and water After separating the organic layer the aqueous layer was extracted with EtOAc three times The combined organic layers was dried over Na2SO4 concentrated
Source ID: ord-0e0d6802bbec4410b6ba92c729e66ce8Conditions: temp:-78.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: In a round-bottomed flask was charged tert-butyl 2-oxopyrrolidine-1-carboxylate (2.2 g, 11.9 mmol) and THF (25 mL). The mixture was cooled down to −78° C. first, followed by slow addition of (3-fluorophenyl)magnesium bromide (17.8 mL, 17.8 mmol, 1.0 M solution in THF) over 15 minutes. The mixture was stirred for 3 hours, during which time the bath temperature rose from −78° C. to −10° C. The reaction was quenched by drop-wise addition of 1N HCl (2 mL) and warmed up to ambient temperature, followed by addition of EtOAc and water. After separating the organic layer, the aqueous layer was extracted with EtOAc three times. The combined organic layers was dried over Na2SO4 and concentrated to yield the product as a clear oil. rose from −78° C. to −10° C The reaction was quenched by drop-wise addition of 1N HCl (2 mL) warmed up to ambient temperature followed by addition of EtOAc and water After separating the organic layer the aqueous layer was extracted with EtOAc three times The combined organic layers was dried over Na2SO4 concentrated
Source ID: ord-77a50d4f3c10483a9e22609fae4a53caConditions: temp:-78.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: In a round-bottomed flask was charged tert-butyl 2-oxopyrrolidine-1-carboxylate (2.2 g, 11.9 mmol) and THF (25 mL). The mixture was cooled down to −78° C. first, followed by slow addition of (3-fluorophenyl)magnesium bromide (17.8 mL, 17.8 mmol, 1.0 M solution in THF) over 15 minutes. The mixture was stirred for 3 hours, during which time the bath temperature rose from −78° C. to −10° C. The reaction was quenched by drop-wise addition of 1N HCl (2 mL) and warmed up to ambient temperature, followed by addition of EtOAc and water. After separating the organic layer, the aqueous layer was extracted with EtOAc three times. The combined organic layers was dried over Na2SO4 and concentrated to yield the product as a clear oil. rose from −78° C. to −10° C The reaction was quenched by drop-wise addition of 1N HCl (2 mL) warmed up to ambient temperature followed by addition of EtOAc and water After separating the organic layer the aqueous layer was extracted with EtOAc three times The combined organic layers was dried over Na2SO4 concentrated
Source ID: ord-60fe492f43d248fbb509432194bb4e54Conditions: temp:-78.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: In a round-bottomed flask was charged tert-butyl 2-oxopyrrolidine-1-carboxylate (2.2 g, 11.9 mmol) and THF (25 mL). The mixture was cooled down to −78° C. first, followed by slow addition of (3-fluorophenyl)magnesium bromide (17.8 mL, 17.8 mmol, 1.0 M solution in THF) over 15 minutes. The mixture was stirred for 3 hours, during which time the bath temperature rose from −78° C. to −10° C. The reaction was quenched by drop-wise addition of 1N HCl (2 mL) and warmed up to ambient temperature, followed by addition of EtOAc and water. After separating the organic layer, the aqueous layer was extracted with EtOAc three times. The combined organic layers was dried over Na2SO4 and concentrated to yield the product as a clear oil. rose from −78° C. to −10° C The reaction was quenched by drop-wise addition of 1N HCl (2 mL) warmed up to ambient temperature followed by addition of EtOAc and water After separating the organic layer the aqueous layer was extracted with EtOAc three times The combined organic layers was dried over Na2SO4 concentrated
Source ID: ord-274f67140ff64dffb426ac3f96e73c7bConditions: temp:-78.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: In a round-bottomed flask was charged tert-butyl 2-oxopyrrolidine-1-carboxylate (2.2 g, 11.9 mmol) and THF (25 mL). The mixture was cooled down to −78° C. first, followed by slow addition of (3-fluorophenyl)magnesium bromide (17.8 mL, 17.8 mmol, 1.0 M solution in THF) over 15 minutes. The mixture was stirred for 3 hours, during which time the bath temperature rose from −78° C. to −10° C. The reaction was quenched by drop-wise addition of 1N HCl (2 mL) and warmed up to ambient temperature, followed by addition of EtOAc and water. After separating the organic layer, the aqueous layer was extracted with EtOAc three times. The combined organic layers was dried over Na2SO4 and concentrated to yield the product as a clear oil. rose from −78° C. to −10° C The reaction was quenched by drop-wise addition of 1N HCl (2 mL) warmed up to ambient temperature followed by addition of EtOAc and water After separating the organic layer the aqueous layer was extracted with EtOAc three times The combined organic layers was dried over Na2SO4 concentrated
Source ID: ord-0e0d6802bbec4410b6ba92c729e66ce8PubChem References
These sources are listed in the compound's public database record.
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