No renderable structure data available
C1COC(=O)N1C2=C(C=C(C=C2)Cl)C#NChemical Intermediate
Structures, identifiers and computed properties have been matched to the database record by CAS.
| Intermediates | 5-chloro-2-(2-oxo-1,3-oxazolidin-3-yl)benzonitrile |
|---|---|
| IUPAC Name | — |
| CAS Number | 1192348-50-7 |
| Database ID | 66896096 |
| Molecular Formula | — |
| Molecular Weight | — |
Product Information
5-chloro-2-(2-oxo-1,3-oxazolidin-3-yl)benzonitrile (CAS 1192348-50-7) product identity, structure identifiers and related reaction data for chemical intermediate research and sourcing review.
Potential Applications
For professional research and industrial use only
Database ID 66896096
Safety Notice
For professional research and industrial use only. Review the supplier safety data sheet before handling.
Synthesis data
10 reactions · 10 references
Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-e7d2cd6f996c4926b5e2d9c2bf1a1d8dConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: (Step 1) To a solution (of 2-oxazolidone (1.23 g) in N,N-dimethylformamide (20 ml) was added sodium hydride (0.62 g) under ice-cooling, and the mixture was stirred for 5 min. 5-Chloro-2-fluorobenzonitrile (2.0 g) was added, and the mixture was stirred at room temperature for 2 hr. Saturated brine was added to the reaction solution, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, dried over magnesium sulfate, and filtered. The solvent was evaporated under reduced pressure. The residue was crystallized from ethyl acetate-hexane to give 5-chloro-2-(2-oxo-1,3-oxazolidin-3-yl)benzonitrile (1.8 g) as a white solid. cooling the mixture was stirred at room temperature for 2 hr the mixture was extracted with ethyl acetate The organic layer was washed with saturated brine dried over magnesium sulfate filtered The solvent was evaporated under reduced pressure The residue was crystallized from ethyl acetate-hexane
Source ID: ord-0afdf24e873940578bf25a280dc12500Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: (Step 1) To a solution (of 2-oxazolidone (1.23 g) in N,N-dimethylformamide (20 ml) was added sodium hydride (0.62 g) under ice-cooling, and the mixture was stirred for 5 min. 5-Chloro-2-fluorobenzonitrile (2.0 g) was added, and the mixture was stirred at room temperature for 2 hr. Saturated brine was added to the reaction solution, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, dried over magnesium sulfate, and filtered. The solvent was evaporated under reduced pressure. The residue was crystallized from ethyl acetate-hexane to give 5-chloro-2-(2-oxo-1,3-oxazolidin-3-yl)benzonitrile (1.8 g) as a white solid. cooling the mixture was stirred at room temperature for 2 hr the mixture was extracted with ethyl acetate The organic layer was washed with saturated brine dried over magnesium sulfate filtered The solvent was evaporated under reduced pressure The residue was crystallized from ethyl acetate-hexane
Source ID: ord-0afdf24e873940578bf25a280dc12500Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: (Step 1) To a solution (of 2-oxazolidone (1.23 g) in N,N-dimethylformamide (20 ml) was added sodium hydride (0.62 g) under ice-cooling, and the mixture was stirred for 5 min. 5-Chloro-2-fluorobenzonitrile (2.0 g) was added, and the mixture was stirred at room temperature for 2 hr. Saturated brine was added to the reaction solution, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, dried over magnesium sulfate, and filtered. The solvent was evaporated under reduced pressure. The residue was crystallized from ethyl acetate-hexane to give 5-chloro-2-(2-oxo-1,3-oxazolidin-3-yl)benzonitrile (1.8 g) as a white solid. cooling the mixture was stirred at room temperature for 2 hr the mixture was extracted with ethyl acetate The organic layer was washed with saturated brine dried over magnesium sulfate filtered The solvent was evaporated under reduced pressure The residue was crystallized from ethyl acetate-hexane
Source ID: ord-b0f9eb6921f54d4391d748845324f4ecConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: (Step 1) To a solution (of 2-oxazolidone (1.23 g) in N,N-dimethylformamide (20 ml) was added sodium hydride (0.62 g) under ice-cooling, and the mixture was stirred for 5 min. 5-Chloro-2-fluorobenzonitrile (2.0 g) was added, and the mixture was stirred at room temperature for 2 hr. Saturated brine was added to the reaction solution, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, dried over magnesium sulfate, and filtered. The solvent was evaporated under reduced pressure. The residue was crystallized from ethyl acetate-hexane to give 5-chloro-2-(2-oxo-1,3-oxazolidin-3-yl)benzonitrile (1.8 g) as a white solid. cooling the mixture was stirred at room temperature for 2 hr the mixture was extracted with ethyl acetate The organic layer was washed with saturated brine dried over magnesium sulfate filtered The solvent was evaporated under reduced pressure The residue was crystallized from ethyl acetate-hexane
Source ID: ord-37cec8130bfc4cb79db17d94661bfd42Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: (Step 1) To a solution (of 2-oxazolidone (1.23 g) in N,N-dimethylformamide (20 ml) was added sodium hydride (0.62 g) under ice-cooling, and the mixture was stirred for 5 min. 5-Chloro-2-fluorobenzonitrile (2.0 g) was added, and the mixture was stirred at room temperature for 2 hr. Saturated brine was added to the reaction solution, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, dried over magnesium sulfate, and filtered. The solvent was evaporated under reduced pressure. The residue was crystallized from ethyl acetate-hexane to give 5-chloro-2-(2-oxo-1,3-oxazolidin-3-yl)benzonitrile (1.8 g) as a white solid. cooling the mixture was stirred at room temperature for 2 hr the mixture was extracted with ethyl acetate The organic layer was washed with saturated brine dried over magnesium sulfate filtered The solvent was evaporated under reduced pressure The residue was crystallized from ethyl acetate-hexane
Source ID: ord-37cec8130bfc4cb79db17d94661bfd42Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-e7d2cd6f996c4926b5e2d9c2bf1a1d8dConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: (Step 1) To a solution (of 2-oxazolidone (1.23 g) in N,N-dimethylformamide (20 ml) was added sodium hydride (0.62 g) under ice-cooling, and the mixture was stirred for 5 min. 5-Chloro-2-fluorobenzonitrile (2.0 g) was added, and the mixture was stirred at room temperature for 2 hr. Saturated brine was added to the reaction solution, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, dried over magnesium sulfate, and filtered. The solvent was evaporated under reduced pressure. The residue was crystallized from ethyl acetate-hexane to give 5-chloro-2-(2-oxo-1,3-oxazolidin-3-yl)benzonitrile (1.8 g) as a white solid. cooling the mixture was stirred at room temperature for 2 hr the mixture was extracted with ethyl acetate The organic layer was washed with saturated brine dried over magnesium sulfate filtered The solvent was evaporated under reduced pressure The residue was crystallized from ethyl acetate-hexane
Source ID: ord-0afdf24e873940578bf25a280dc12500Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: (Step 1) To a solution (of 2-oxazolidone (1.23 g) in N,N-dimethylformamide (20 ml) was added sodium hydride (0.62 g) under ice-cooling, and the mixture was stirred for 5 min. 5-Chloro-2-fluorobenzonitrile (2.0 g) was added, and the mixture was stirred at room temperature for 2 hr. Saturated brine was added to the reaction solution, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, dried over magnesium sulfate, and filtered. The solvent was evaporated under reduced pressure. The residue was crystallized from ethyl acetate-hexane to give 5-chloro-2-(2-oxo-1,3-oxazolidin-3-yl)benzonitrile (1.8 g) as a white solid. cooling the mixture was stirred at room temperature for 2 hr the mixture was extracted with ethyl acetate The organic layer was washed with saturated brine dried over magnesium sulfate filtered The solvent was evaporated under reduced pressure The residue was crystallized from ethyl acetate-hexane
Source ID: ord-b0f9eb6921f54d4391d748845324f4ecConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: (Step 1) To a solution (of 2-oxazolidone (1.23 g) in N,N-dimethylformamide (20 ml) was added sodium hydride (0.62 g) under ice-cooling, and the mixture was stirred for 5 min. 5-Chloro-2-fluorobenzonitrile (2.0 g) was added, and the mixture was stirred at room temperature for 2 hr. Saturated brine was added to the reaction solution, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, dried over magnesium sulfate, and filtered. The solvent was evaporated under reduced pressure. The residue was crystallized from ethyl acetate-hexane to give 5-chloro-2-(2-oxo-1,3-oxazolidin-3-yl)benzonitrile (1.8 g) as a white solid. cooling the mixture was stirred at room temperature for 2 hr the mixture was extracted with ethyl acetate The organic layer was washed with saturated brine dried over magnesium sulfate filtered The solvent was evaporated under reduced pressure The residue was crystallized from ethyl acetate-hexane
Source ID: ord-37cec8130bfc4cb79db17d94661bfd42PubChem References
These sources are listed in the compound's public database record.
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