methyl (2R)-2-amino-2-methylbutanoate

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: The (R)-isovaline methyl ester hydrochloride may be converted to (R)-N-(3-chloro-1-ethyl- 1-methyl-2-oxopropyl)-3,5-dichloro-4-methylbenzamide (mp. 155.5-156° C., [α]D=+4.14 in ethanol) using the above-described sequence for preparation of the (S)-enantiomer. for preparation of the (S)-enantiomer

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: The (R)-isovaline methyl ester hydrochloride may be converted to (R)-N-(3-chloro-1-ethyl- 1-methyl-2-oxopropyl)-3,5-dichloro-4-methylbenzamide (mp. 155.5-156° C., [α]D=+4.14 in ethanol) using the above-described sequence for preparation of the (S)-enantiomer. for preparation of the (S)-enantiomer

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: The (R)-isovaline methyl ester hydrochloride may be converted to (R)-N-(3-chloro-1-ethyl- 1-methyl-2-oxopropyl)-3,5-dichloro-4-methylbenzamide (mp. 155.5-156° C., [α]D=+4.14 in ethanol) using the above-described sequence for preparation of the (S)-enantiomer. for preparation of the (S)-enantiomer

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: The (R)-isovaline methyl ester hydrochloride may be converted to (R)-N-(3-chloro-1-ethyl- 1-methyl-2-oxopropyl)-3,5-dichloro-4-methylbenzamide (mp. 155.5-156° C., [α]D=+4.14 in ethanol) using the above-described sequence for preparation of the (S)-enantiomer. for preparation of the (S)-enantiomer