No renderable structure data available
COC(=O)CCCCC(=O)ON1C(=O)CCC1=OChemical Intermediate
Structures, identifiers and computed properties have been matched to the database record by CAS.
| Intermediates | 6-O-(2,5-dioxopyrrolidin-1-yl) 1-O-methyl hexanedioate |
|---|---|
| IUPAC Name | — |
| CAS Number | 118380-06-6 |
| Database ID | 4458286 |
| Molecular Formula | — |
| Molecular Weight | — |
Product Information
6-O-(2,5-dioxopyrrolidin-1-yl) 1-O-methyl hexanedioate (CAS 118380-06-6) product identity, structure identifiers and related reaction data for chemical intermediate research and sourcing review.
Potential Applications
For professional research and industrial use only
Database ID 4458286
Safety Notice
For professional research and industrial use only. Review the supplier safety data sheet before handling.
Synthesis data
12 reactions · 12 references
Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-61f2a60045fd461899e3f60ddf7577b4Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A solution of methyl succinimidyl adipate (4.5 g, 17.5 mmol), chlorotrimethylsilane (11.1 ml, 87.5 mmol) and sodium iodide (13.1 g, 87.5 mmol) in 10 ml of acetonitrile was heated at reflux for 12 hours. The mixture was then cooled to room temperature and diluted with ethyl acetate. The reaction mixture was washed repeatedly with 5 percent aqueous sodium bisulfite until the organic solution was colorless. Then it was washed with brine, dried over anhydrous magnesium sulfate, filtered and concentrated to provide 3.2 g (71 percent yield by weight) of adipic acid monosuccinimidyl ester as a white solid. at reflux for 12 hours The reaction mixture was washed repeatedly with 5 percent aqueous sodium bisulfite until the organic solution Then it was washed with brine dried over anhydrous magnesium sulfate filtered concentrated
Source ID: ord-b421e2ead8834c3facc6be62830614a1Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A solution of methyl succinimidyl adipate (4.5 g, 17.5 mmol), chlorotrimethylsilane (11.1 ml, 87.5 mmol) and sodium iodide (13.1 g, 87.5 mmol) in 10 ml of acetonitrile was heated at reflux for 12 hours. The mixture was then cooled to room temperature and diluted with ethyl acetate. The reaction mixture was washed repeatedly with 5 percent aqueous sodium bisulfite until the organic solution was colorless. Then it was washed with brine, dried over anhydrous magnesium sulfate, filtered and concentrated to provide 3.2 g (71 percent yield by weight) of adipic acid monosuccinimidyl ester as a white solid. at reflux for 12 hours The reaction mixture was washed repeatedly with 5 percent aqueous sodium bisulfite until the organic solution Then it was washed with brine dried over anhydrous magnesium sulfate filtered concentrated
Source ID: ord-0e4b65e135004351a70e7dc493482219Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A solution of methyl succinimidyl adipate (4.5 g, 17.5 mmol), chlorotrimethylsilane (11.1 ml, 87.5 mmol) and sodium iodide (13.1 g, 87.5 mmol) in 10 ml of acetonitrile was heated at reflux for 12 hours. The mixture was then cooled to room temperature and diluted with ethyl acetate. The reaction mixture was washed repeatedly with 5 percent aqueous sodium bisulfite until the organic solution was colorless. Then it was washed with brine, dried over anhydrous magnesium sulfate, filtered and concentrated to provide 3.2 g (71 percent yield by weight) of adipic acid monosuccinimidyl ester as a white solid. at reflux for 12 hours The reaction mixture was washed repeatedly with 5 percent aqueous sodium bisulfite until the organic solution Then it was washed with brine dried over anhydrous magnesium sulfate filtered concentrated
Source ID: ord-11ded5dc5bf84e10a5c9ac7f08bd70a1Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A solution of methyl succinimidyl adipate (4.5 g, 17.5 mmol), chlorotrimethylsilane (11.1 ml, 87.5 mmol) and sodium iodide (13.1 g, 87.5 mmol) in 10 ml of acetonitrile was heated at reflux for 12 hours. The mixture was then cooled to room temperature and diluted with ethyl acetate. The reaction mixture was washed repeatedly with 5 percent aqueous sodium bisulfite until the organic solution was colorless. Then it was washed with brine, dried over anhydrous magnesium sulfate, filtered and concentrated to provide 3.2 g (71 percent yield by weight) of adipic acid monosuccinimidyl ester as a white solid. at reflux for 12 hours The reaction mixture was washed repeatedly with 5 percent aqueous sodium bisulfite until the organic solution Then it was washed with brine dried over anhydrous magnesium sulfate filtered concentrated
Source ID: ord-6ee06cc338d74b2ebea19761b8727ee9Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-61f2a60045fd461899e3f60ddf7577b4Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A solution of methyl succinimidyl adipate (4.5 g, 17.5 mmol), chlorotrimethylsilane (11.1 ml, 87.5 mmol) and sodium iodide (13.1 g, 87.5 mmol) in 10 ml of acetonitrile was heated at reflux for 12 hours. The mixture was then cooled to room temperature and diluted with ethyl acetate. The reaction mixture was washed repeatedly with 5 percent aqueous sodium bisulfite until the organic solution was colorless. Then it was washed with brine, dried over anhydrous magnesium sulfate, filtered and concentrated to provide 3.2 g (71 percent yield by weight) of adipic acid monosuccinimidyl ester as a white solid. at reflux for 12 hours The reaction mixture was washed repeatedly with 5 percent aqueous sodium bisulfite until the organic solution Then it was washed with brine dried over anhydrous magnesium sulfate filtered concentrated
Source ID: ord-6ee06cc338d74b2ebea19761b8727ee9Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A solution of methyl succinimidyl adipate (4.5 g, 17.5 mmol), chlorotrimethylsilane (11.1 ml, 87.5 mmol) and sodium iodide (13.1 g, 87.5 mmol) in 10 ml of acetonitrile was heated at reflux for 12 hours. The mixture was then cooled to room temperature and diluted with ethyl acetate. The reaction mixture was washed repeatedly with 5 percent aqueous sodium bisulfite until the organic solution was colorless. Then it was washed with brine, dried over anhydrous magnesium sulfate, filtered and concentrated to provide 3.2 g (71 percent yield by weight) of adipic acid monosuccinimidyl ester as a white solid. at reflux for 12 hours The reaction mixture was washed repeatedly with 5 percent aqueous sodium bisulfite until the organic solution Then it was washed with brine dried over anhydrous magnesium sulfate filtered concentrated
Source ID: ord-5f655c6ba110436886cd9e450e375530Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A solution of methyl succinimidyl adipate (4.5 g, 17.5 mmol), chlorotrimethylsilane (11.1 ml, 7.5 mmol) and sodium iodide (13.1 g, 87.5 mmol) in 10 ml of acetonitrile was heated at reflux for 12 hours. The mixture was then cooled to room temperature and diluted with ethyl acetate. The reaction mixture was washed repeatedly with 5 percent aqueous sodium bisulfite until the organic solution was colorless. Then it was washed with brine, dried over anhydrous magnesium sulfate, filtered and concentrated to provide 3.2 pg (71 percent yield by weight) of adipic acid monosuccinimidyl ester as a white solid. at reflux for 12 hours The reaction mixture was washed repeatedly with 5 percent aqueous sodium bisulfite until the organic solution Then it was washed with brine dried over anhydrous magnesium sulfate filtered concentrated
Source ID: ord-208506fc77e1499ba20693221f23f956Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A solution of methyl succinimidyl adipate (4.5 g, 17.5 mmol), chlorotrimethylsilane (11.1 ml, 87.5 mmol) and sodium iodide (13.1 g, 87.5 mmol) in 10 ml of acetonitrile was heated at reflux for 12 hours. The mixture was then cooled to room temperature and diluted with ethyl acetate. The reaction mixture was washed repeatedly with 5 percent aqueous sodium bisulfite until the organic solution was colorless. Then it was washed with brine, dried over anhydrous magnesium sulfate, filtered and concentrated to provide 3.2 g (71 percent yield by weight) of adipic acid monosuccinimidyl ester as a white solid. at reflux for 12 hours The reaction mixture was washed repeatedly with 5 percent aqueous sodium bisulfite until the organic solution Then it was washed with brine dried over anhydrous magnesium sulfate filtered concentrated
Source ID: ord-b421e2ead8834c3facc6be62830614a1Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A solution of methyl succinimidyl adipate (4.5 g, 17.5 mmol), chlorotrimethylsilane (11.1 ml, 87.5 mmol) and sodium iodide (13.1 g, 87.5 mmol) in 10 ml of acetonitrile was heated at reflux for 12 hours. The mixture was then cooled to room temperature and diluted with ethyl acetate. The reaction mixture was washed repeatedly with 5 percent aqueous sodium bisulfite until the organic solution was colorless. Then it was washed with brine, dried over anhydrous magnesium sulfate, filtered and concentrated to provide 3.2 g (71 percent yield by weight) of adipic acid monosuccinimidyl ester as a white solid. at reflux for 12 hours The reaction mixture was washed repeatedly with 5 percent aqueous sodium bisulfite until the organic solution Then it was washed with brine dried over anhydrous magnesium sulfate filtered concentrated
Source ID: ord-0e4b65e135004351a70e7dc493482219Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A solution of methyl succinimidyl adipate (4.5 g, 17.5 mmol), chlorotrimethylsilane (11.1 ml, 87.5 mmol) and sodium iodide (13.1 g, 87.5 mmol) in 10 ml of acetonitrile was heated at reflux for 12 hours. The mixture was then cooled to room temperature and diluted with ethyl acetate. The reaction mixture was washed repeatedly with 5 percent aqueous sodium bisulfite until the organic solution was colorless. Then it was washed with brine, dried over anhydrous magnesium sulfate, filtered and concentrated to provide 3.2 g (71 percent yield by weight) of adipic acid monosuccinimidyl ester as a white solid. at reflux for 12 hours The reaction mixture was washed repeatedly with 5 percent aqueous sodium bisulfite until the organic solution Then it was washed with brine dried over anhydrous magnesium sulfate filtered concentrated
Source ID: ord-11ded5dc5bf84e10a5c9ac7f08bd70a1PubChem References
These sources are listed in the compound's public database record.
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