No renderable structure data available
CC1=C(C=C[N+](=C1C)[O-])OCCCOCChemical Intermediate
Structures, identifiers and computed properties have been matched to the database record by CAS.
| Intermediates | 4-(3-methoxypropoxy)-2,3-dimethyl-1-oxidopyridin-1-ium |
|---|---|
| IUPAC Name | — |
| CAS Number | 117977-18-1 |
| Database ID | 10013379 |
| Molecular Formula | — |
| Molecular Weight | — |
Product Information
4-(3-methoxypropoxy)-2,3-dimethyl-1-oxidopyridin-1-ium (CAS 117977-18-1) product identity, structure identifiers and related reaction data for chemical intermediate research and sourcing review.
Potential Applications
For professional research and industrial use only
Database ID 10013379
Safety Notice
For professional research and industrial use only. Review the supplier safety data sheet before handling.
Synthesis data
12 reactions · 12 references
Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-43e7a1f4426540f69a855fdd114cbb28Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 20 ml of acetic anhydride was added to 760 mg (3.6 mmol) of 4-(3-methoxypropoxy)-2,3-dimethylpyridine N-oxide to carry out the reaction at 90° C. for one hour. The reaction mixture was distilled to remove the acetic anhydride, followed by the addition of a saturated aqueous solution of sodium hydrogencarbonate. The obtained mixture was extracted with chloroform. The extract was concentrated to obtain 700 mg of 2-acetoxymethyl-4-(3-methoxypropoxy)-3-methylpyridine as a brown oil. the reaction at 90° C. for one hour The reaction mixture was distilled to remove the acetic anhydride followed by the addition of a saturated aqueous solution of sodium hydrogencarbonate The obtained mixture was extracted with chloroform The extract was concentrated
Source ID: ord-8708b14f43ea47bba3c96cd1cdc4ce54Conditions: temp:60.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 2.0 g (22 mmol) of 3-methoxypropanol was dissolved in 50 ml of dimethyl sulfoxide to obtain a solution. 2.7 g (66 mmol) of sodium hydride was added to this solution at a room temperature. The obtained mixture was stirred at 60° C. for one hour and cooled to a room temperature by allowing to stand, followed by the addition of 3.0 g (19 mmol) of 4-chloro-2,3-dimethylpyridine N-oxide. The obtained mixture was stirred at 40° C. for one hour. After the completion of the reaction, the reaction mixture was distilled to remove the dimethyl sulfoxide. The obtained residue was purified by silica gel column chromatography to obtain 760 mg of 4-(3-methoxypropoxy)-2,3-dimethylpyridine N-oxide. to obtain a solution cooled to a room temperature The obtained mixture was stirred at 40° C. for one hour After the completion of the reaction the reaction mixture was distilled to remove the dimethyl sulfoxide The obtained residue was purified by silica gel column chromatography
Source ID: ord-c62d67866a9944eb97404d24bbe4f243Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 20 ml of acetic anhydride was added to 760 mg (3.6 mmol) of 4-(3-methoxypropoxy)-2,3-dimethylpyridine N-oxide to carry out the reaction at 90° C. for one hour. The reaction mixture was distilled to remove the acetic anhydride, followed by the addition of a saturated aqueous solution of sodium hydrogencarbonate. The obtained mixture was extracted with chloroform. The extract was concentrated to obtain 700 mg of 2-acetoxymethyl-4-(3-methoxypropoxy)-3-methylpyridine as a brown oil. the reaction at 90° C. for one hour The reaction mixture was distilled to remove the acetic anhydride followed by the addition of a saturated aqueous solution of sodium hydrogencarbonate The obtained mixture was extracted with chloroform The extract was concentrated
Source ID: ord-9c5b0d1ffbbd493daaf378fa7540fc51Conditions: temp:60.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 2.0 g (22 mmol) of 3-methoxypropanol was dissolved in 50 ml of dimethyl sulfoxide to obtain a solution. 2.7 g (66 mmol) of sodium hydride was added to this solution at a room temperature. The obtained mixture was stirred at 60° C. for one hour and cooled to a room temperature by allowing to stand, followed by the addition of 3.0 g (19 mmol) of 4-chloro-2,3-dimethylpyridine N-oxide. The obtained mixture was stirred at 40° C. for one hour. After the completion of the reaction, the reaction mixture was distilled to remove the dimethyl sulfoxide. The obtained residue was purified by silica gel column chromatography to obtain 760 mg of 4-(3-methoxypropoxy)-2,3-dimethylpyridine N-oxide. to obtain a solution cooled to a room temperature The obtained mixture was stirred at 40° C. for one hour After the completion of the reaction the reaction mixture was distilled to remove the dimethyl sulfoxide The obtained residue was purified by silica gel column chromatography
Source ID: ord-6065832ac4f342808f337ee295a7027fConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 20 ml of acetic anhydride was added to 760 mg (3.6 mmol) of 4-(3-methoxypropoxy)-2,3-dimethyl-pyridine N-oxide to carry out the reaction at 90° C. for one hour. The reaction mixture was distilled to remove the acetic anhydride, followed by the addition of a saturated aqueous solution of sodium hydrogen-carbonate. The obtained mixture was extracted with chloroform. The extract was concentrated to obtain 700 mg of 2-acetoxymethyl-4-(3-methoxypropoxy)-3-methylpyridine as a brown oil. 500 mg of sodium hydroxide and 15 cc of ethanol were added to the 2-acetoxymethyl-4-(3-methoxypropoxy)-3-methylpyridine prepared above. The obtained mixture was stirred at 50° C. for one hour. After the completion of the reaction, the reaction mixture was distilled to remove the ethanol, followed by the addition of water. The obtained mixture was extracted with chloroform. The obtained chloroform layer was concentrated to obtain 450 mg of 2-hydroxymethyl-4-(3-methoxypropoxy)-3-methylpyridine as a brown oil. the reaction at 90° C. for one hour The reaction mixture was distilled to remove the acetic anhydride followed by the addition of a saturated aqueous solution of sodium hydrogen-carbonate The obtained mixture was extracted with chloroform The extract was concentrated
Source ID: ord-f3cb4e8f863847d4bfd08e36a4b0e29fConditions: temp:60.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 2.0 g (22 mmol) of 3-methoxypropanol was dissolved in 50 ml of dimethyl sulfoxide to obtain a solution. 2.7 g (66 mmol) of sodium hydride was added to this solution at a room temperature. The obtained mixture was stirred at 60° C. for one hour and cooled to a room temperature by allowing to stand, followed by the addition of 3.0 g (19 mmol) of 4-chloro-2,3-dimethylpyridine N-oxide. The obtained mixture was stirred at 40° C. for one hour. After the completion of the reaction, the reaction mixture was distilled to remove the dimethyl sulfoxide. The obtained residue was purified by silica gel column chromatography to obtain 760 mg of 4-(3-methoxypropoxy)-2,3-dimethyl-pyridine N-oxide. to obtain a solution cooled to a room temperature The obtained mixture was stirred at 40° C. for one hour After the completion of the reaction the reaction mixture was distilled to remove the dimethyl sulfoxide The obtained residue was purified by silica gel column chromatography
Source ID: ord-587aa44822454a5f84f794e15d2c9f6dConditions: temp:60.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 2.0 g (22 mmol) of 3-methoxypropanol was dissolved in 50 ml of dimethyl sulfoxide to obtain a solution. 2.7 g (66 mmol) of sodium hydride was added to this solution at a room temperature. The obtained mixture was stirred at 60° C. for one hour and cooled to a room temperature by allowing to stand, followed by the addition of 3.0 g (19 mmol) of 4-chloro-2,3-dimethylpyridine N-oxide. The obtained mixture was stirred at 40° C. for one hour. After the completion of the reaction, the reaction mixture was distilled to remove the dimethyl sulfoxide. The obtained residue was purified by silica gel column chromatography to obtain 760 mg of 4-(3-methoxypropoxy)-2,3-dimethyl-pyridine N-oxide. to obtain a solution cooled to a room temperature The obtained mixture was stirred at 40° C. for one hour After the completion of the reaction the reaction mixture was distilled to remove the dimethyl sulfoxide The obtained residue was purified by silica gel column chromatography
Source ID: ord-587aa44822454a5f84f794e15d2c9f6dConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 20 ml of acetic anhydride was added to 760 mg (3.6 mmol) of 4-(3-methoxypropoxy)-2,3-dimethylpyridine N-oxide to carry out the reaction at 90° C. for one hour. The reaction mixture was distilled to remove the acetic anhydride, followed by the addition of a saturated aqueous solution of sodium hydrogencarbonate. The obtained mixture was extracted with chloroform. The extract was concentrated to obtain 700 mg of 2-acetoxymethyl-4-(3-methoxypropoxy)-3-methylpyridine as a brown oil. the reaction at 90° C. for one hour The reaction mixture was distilled to remove the acetic anhydride followed by the addition of a saturated aqueous solution of sodium hydrogencarbonate The obtained mixture was extracted with chloroform The extract was concentrated
Source ID: ord-8708b14f43ea47bba3c96cd1cdc4ce54Conditions: temp:60.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 2.0 g (22 mmol) of 3-methoxypropanol was dissolved in 50 ml of dimethyl sulfoxide to obtain a solution. 2.7 g (66 mmol) of sodium hydride was added to this solution at a room temperature. The obtained mixture was stirred at 60° C. for one hour and cooled to a room temperature by allowing to stand, followed by the addition of 3.0 g (19 mmol) of 4-chloro-2,3-dimethylpyridine N-oxide. The obtained mixture was stirred at 40° C. for one hour. After the completion of the reaction, the reaction mixture was distilled to remove the dimethyl sulfoxide. The obtained residue was purified by silica gel column chromatography to obtain 760 mg of 4-(3-methoxypropoxy)-2,3-dimethylpyridine N-oxide. to obtain a solution cooled to a room temperature The obtained mixture was stirred at 40° C. for one hour After the completion of the reaction the reaction mixture was distilled to remove the dimethyl sulfoxide The obtained residue was purified by silica gel column chromatography
Source ID: ord-c62d67866a9944eb97404d24bbe4f243Conditions: temp:60.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 2.0 g (22 mmol) of 3-methoxypropanol was dissolved in 50 ml of dimethyl sulfoxide to obtain a solution. 2.7 g (66 mmol) of sodium hydride was added to this solution at a room temperature. The obtained mixture was stirred at 60° C. for one hour and cooled to a room temperature by allowing to stand, followed by the addition of 3.0 g (19 mmol) of 4-chloro-2,3-dimethylpyridine N-oxide. The obtained mixture was stirred at 40° C. for one hour. After the completion of the reaction, the reaction mixture was distilled to remove the dimethyl sulfoxide. The obtained residue was purified by silica gel column chromatography to obtain 760 mg of 4-(3-methoxypropoxy)-2,3-dimethylpyridine N-oxide. to obtain a solution cooled to a room temperature The obtained mixture was stirred at 40° C. for one hour After the completion of the reaction the reaction mixture was distilled to remove the dimethyl sulfoxide The obtained residue was purified by silica gel column chromatography
Source ID: ord-c62d67866a9944eb97404d24bbe4f243Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-43e7a1f4426540f69a855fdd114cbb28PubChem References
These sources are listed in the compound's public database record.
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