tert-butyl N-[(2S)-1-cyclopropyl-1-oxopropan-2-yl]carbamate

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: A solution of diisopropylamine (4.06 g) in tetrahydrofuran (40 mL) was ice-cooled under a nitrogen atmosphere, and 1.6 mol/L n-butyllithium-hexane solution (24.6 mL) was added. The mixture was stirred at the same temperature for 20 min, and the reaction solution was cooled with dry ice/acetone. Ethyl acetate (3.88 ml) was added to the reaction solution, the mixture was stirred at the same temperature for 30 min, and a solution of tert-butyl [(1S)-2-cyclopropyl-1-methyl-2-oxoethyl]carbamate (3.65 g) in tetrahydrofuran (10 mL) was added. The mixture was stirred at the same temperature for 7 hr, saturated aqueous ammonium chloride solution (100 mL) was added, and the mixture was extracted with ethyl acetate. The obtained organic layer was washed with water and saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: ethyl acetate/hexane=0→30%), the obtained oil was dissolved in 4 mol/L hydrogen chloride-ethyl acetate solution (30 mL), and the mixture was stirred at room temperature for 2 hr. The reaction solution was concentrated under reduced pressure, the residue was dissolved in tetrahydrofuran (80 mL), and diisopropylethylamine (8.09 mL) was added. The reaction solution was refluxed under heating for 4 hr, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: methanol/ethyl acetate=0→5%), and the obtained solid was recrystallized from ethyl acetate/hexane to give the title compound as colorless crystals (yield: 1.65 g, 71%). cooled under a nitrogen atmosphere 1.6 mol/L n-butyllithium-hexane solution (24.6 mL) was added the mixture was stirred at the same temperature for 30 min The mixture was stirred at the same temperature for 7 hr the mixture was extracted with ethyl acetate The obtained organic layer was washed with water and saturated brine dried over anhydrous magnesium sulfate concentrated under reduced pressure The residue was purified by silica gel column chromatography (eluent: ethyl acetate/hexane=0→30%) the obtained oil was dissolved in 4 mol/L hydrogen chloride-ethyl acetate solution (30 mL) the mixture was stirred at room temperature for 2 hr The reaction solution was concentrated under reduced pressure the residue was dissolved in tetrahydrofuran (80 mL) diisopropylethylamine (8.09 mL) was added The reaction solution was refluxed under heating for 4 hr concentrated under reduced pressure The residue was purified by silica gel column chromatography (eluent: methanol/ethyl acetate=0→5%) the obtained solid was recrystallized from ethyl acetate/hexane

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: A solution of tert-butyl {(15)-1-[methoxy(methyl)carbamoyl]ethyl}carbamate (10.0 g) in tetrahydrofuran (110 mL) was cooled using dry ice/acetone under a nitrogen atmosphere, and 1.0 mol/L-cyclopropylmagnesium bromide/tetrahydrofuran solution (100 mL) was added. The mixture was warmed to room temperature and stirred for 5 hr, saturated aqueous ammonium chloride solution (200 mL) was added to the reaction solution, and the mixture was extracted with ethyl acetate. The obtained organic layer was washed with water and saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: ethyl acetate/hexane=0→30%) to give the title compound as a yellow oil (yield: 3.65 g, 40%). the mixture was extracted with ethyl acetate The obtained organic layer was washed with water and saturated brine dried over anhydrous magnesium sulfate concentrated under reduced pressure The residue was purified by silica gel column chromatography (eluent: ethyl acetate/hexane=0→30%)

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: A solution of diisopropylamine (4.06 g) in tetrahydrofuran (40 mL) was ice-cooled under a nitrogen atmosphere, and 1.6 mol/L n-butyllithium-hexane solution (24.6 mL) was added. The mixture was stirred at the same temperature for 20 min, and the reaction solution was cooled with dry ice/acetone. Ethyl acetate (3.88 mL) was added to the reaction solution, the mixture was stirred at the same temperature for 30 min, and a solution of tert-butyl[(1S)-2-cyclopropyl-1-methyl-2-oxoethyl]carbamate (3.65 g) in tetrahydrofuran (10 mL) was added. The mixture was stirred at the same temperature for 7 hr, saturated aqueous ammonium chloride solution (100 mL) was added, and the mixture was extracted with ethyl acetate. The obtained organic layer was washed with water and saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: ethyl acetate/hexane=0→30%), the obtained oil was dissolved in 4 mol/L hydrogen chloride-ethyl acetate solution (30 mL), and the mixture was stirred at room temperature for 2 hr. The reaction solution was concentrated under reduced pressure, the residue was dissolved in tetrahydrofuran (80 mL), and diisopropylethylamine (8.09 mL) was added. The reaction solution was refluxed under heating for 4 hr, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: methanol/ethyl acetate=0→5%), and the obtained solid was recrystallized from ethyl acetate/hexane to give the title compound as colorless crystals (yield: 1.65 g, 71%). cooled under a nitrogen atmosphere 1.6 mol/L n-butyllithium-hexane solution (24.6 mL) was added the mixture was stirred at the same temperature for 30 min The mixture was stirred at the same temperature for 7 hr the mixture was extracted with ethyl acetate The obtained organic layer was washed with water and saturated brine dried over anhydrous magnesium sulfate concentrated under reduced pressure The residue was purified by silica gel column chromatography (eluent: ethyl acetate/hexane=0→30%) the obtained oil was dissolved in 4 mol/L hydrogen chloride-ethyl acetate solution (30 mL) the mixture was stirred at room temperature for 2 hr The reaction solution was concentrated under reduced pressure the residue was dissolved in tetrahydrofuran (80 mL) diisopropylethylamine (8.09 mL) was added The reaction solution was refluxed under heating for 4 hr concentrated under reduced pressure The residue was purified by silica gel column chromatography (eluent: methanol/ethyl acetate=0→5%) the obtained solid was recrystallized from ethyl acetate/hexane

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: A solution of tert-butyl{(1S)-1-[methoxy(methyl)carbamoyl]ethyl}carbamate (10.0 g) in tetrahydrofuran (110 mL) was cooled using dry ice/acetone under a nitrogen atmosphere, and 1.0 mol/L-cyclopropylmagnesium bromide/tetrahydrofuran solution (100 mL) was added. The mixture was warmed to room temperature and stirred for 5 hr, saturated aqueous ammonium chloride solution (200 mL) was added to the reaction solution, and the mixture was extracted with ethyl acetate. The obtained organic layer was washed with water and saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: ethyl acetate/hexane=0→30%) to give the title compound as a yellow oil (yield: 3.65 g, 40%). the mixture was extracted with ethyl acetate The obtained organic layer was washed with water and saturated brine dried over anhydrous magnesium sulfate concentrated under reduced pressure The residue was purified by silica gel column chromatography (eluent: ethyl acetate/hexane=0→30%)