1-benzylpiperidine-4-carbonitrile;hydrochloride

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: Dissolve 1-Benzyl-piperidine-4-carbonitrile hydrochloride (1.00 equiv; 57.3 mmoles; 13.57 g) in 75 mL MeOH and cool in ice bath. Saturate with HCl gas for 25 minutes, then remove ice bath and stir for 3 hours. Evaporate under reduced pressure to give 17.47 g (65.0 mmol, 113%) 1-benzyl-piperidine-4-carboximidic acid methyl ester hydrochloride. cool in ice bath Saturate with HCl gas for 25 minutes Evaporate under reduced pressure

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: Dissolve 1-Benzyl-piperidine-4-carbonitrile hydrochloride (1.00 equiv; 57.3 mmoles; 13.57 g) in 75 mL MeOH and cool in ice bath. Saturate with HCl gas for 25 minutes, then remove ice bath and stir for 3 hours. Evaporate under reduced pressure to give 17.47 g (65.0 mmol, 113%) 1-benzyl-piperidine-4-carboximidic acid methyl ester hydrochloride. cool in ice bath Saturate with HCl gas for 25 minutes Evaporate under reduced pressure

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: Dissolve 1-Benzyl-piperidine-4-carbonitrile hydrochloride (1.00 equiv; 57.3 mmoles; 13.57 g) in 75 mL MeOH and cool in ice bath. Saturate with HCl gas for 25 minutes, then remove ice bath and stir for 3 hours. Evaporate under reduced pressure to give 17.47 g (65.0 mmol, 113%) 1-benzyl-piperidine-4-carboximidic acid methyl ester hydrochloride. cool in ice bath Saturate with HCl gas for 25 minutes Evaporate under reduced pressure