No renderable structure data available
ClC1C=CC2=C(C=1)C=C(C)N2[H]Chemical Intermediate
Structures, identifiers and computed properties have been matched to the database record by CAS.
| Intermediates | 5-CHLORO-2-METHYLINDOLE |
|---|---|
| IUPAC Name | — |
| CAS Number | 1075-35-0 |
| Database ID | 70636 |
| Molecular Formula | — |
| Molecular Weight | — |
Product Information
5-CHLORO-2-METHYLINDOLE (CAS 1075-35-0) product identity, structure identifiers and related reaction data for chemical intermediate research and sourcing review.
Potential Applications
For professional research and industrial use only
Database ID 70636
Safety Notice
For professional research and industrial use only. Review the supplier safety data sheet before handling.
Synthesis data
12 reactions · 12 references
Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-d6a928b7c19f496eb1a4a25011cb8880Conditions: temp:60.01; pressure:0.00; stir:
Source ID: ord-2c33c866d4e348449996e934f2708a85Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: The sub-title compound was prepared by the method of Example 40 step a, using 5-chloro-2-methyl-1H-indole and 8-methanesulphonyl-4-chloroquinoline.
Source ID: ord-0f7e6023f6454c3e946e32dd81ea6053Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-d6a928b7c19f496eb1a4a25011cb8880Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-d6a928b7c19f496eb1a4a25011cb8880Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 3,3-Dimethyl-dihydro-furan-2,5-dione (7.8 mmol, 1.0 g), 5-chloro-2-methylindole (13.8 mmol, 2.28 g), and AlCl3 (9.0 mmol, 1.2 g) were stirred in 100 mL DCE overnight at 65° C. The reaction was cooled and quenched with 10 mL water. The resultant precipitate was filtered and washed with a small amount of DCE giving 1.06 g of the sub-titled compound. The reaction was cooled quenched with 10 mL water The resultant precipitate was filtered washed with a small amount of DCE giving 1.06 g of the sub-titled compound
Source ID: ord-fdea7c0e784241ecb857ce778f08894cConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 3,3-Dimethyl-dihydro-furan-2,5-dione (7.8 mmol, 1.0 g), 5-chloro-2-methylindole (13.8 mmol, 2.28 g), and AlCl3 (9.0 mmol, 1.2 g) were stirred in 100 mL DCE overnight at 65° C. The reaction was cooled and quenched with 10 mL water. The resultant precipitate was filtered and washed with a small amount of DCE giving 1.06 g of the sub-titled compound. The reaction was cooled quenched with 10 mL water The resultant precipitate was filtered washed with a small amount of DCE giving 1.06 g of the sub-titled compound
Source ID: ord-fdea7c0e784241ecb857ce778f08894cConditions: temp:65.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 5-Chloro-2-methylindole (0.74 g, 2.26 mmol) and 1,4-dichloro-phthalazine (0.45 g, 2.26 mmol) were treated with 30 mL of 1,2-dichloroethane and 3.2=mmol of AlCl3 (427 mg). The resulting suspension was heated to 65° C. overnight. The reaction was cooled and quenched with 3 mL water. The resultant precipitate was filtered and dried under vacuum to give 0.65 g of the sub-title compound. MS: ESI (negative): 326, 328 (M−H). The reaction was cooled quenched with 3 mL water The resultant precipitate was filtered dried under vacuum
Source ID: ord-41e10260748e46b5ac0bb23c2a6b50aeConditions: temp:65.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 5-Chloro-2-methylindole (0.74 g, 2.26 mmol) and 1,4-dichloro-phthalazine (0.45 g, 2.26 mmol) were treated with 30 mL of 1,2-dichloroethane and 3.2=mmol of AlCl3 (427 mg). The resulting suspension was heated to 65° C. overnight. The reaction was cooled and quenched with 3 mL water. The resultant precipitate was filtered and dried under vacuum to give 0.65 g of the sub-title compound. MS: ESI (negative): 326, 328 (M−H). The reaction was cooled quenched with 3 mL water The resultant precipitate was filtered dried under vacuum
Source ID: ord-41e10260748e46b5ac0bb23c2a6b50aeConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 3,3-Dimethyl-dihydro-furan-2,5-dione (7.8 mmol, 1.0 g), 5-chloro-2-methylindole (13.8 mmol, 2.28 g), and AlCl3 (9.0 mmol, 1.2 g) were stirred in 100 mL DCE overnight at 65° C. The reaction was cooled and quenched with 10 mL water. The resultant precipitate was filtered and washed with a small amount of DCE giving 1.06 g of the sub-titled compound. The reaction was cooled quenched with 10 mL water The resultant precipitate was filtered washed with a small amount of DCE giving 1.06 g of the sub-titled compound
Source ID: ord-7c5e951ea48447a3bd7b0672c648a2e7Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 3,3-Dimethyl-dihydro-furan-2,5-dione (7.8 mmol, 1.0 g), 5-chloro-2-methylindole (13.8 mmol, 2.28 g), and AlCl3 (9.0 mmol, 1.2 g) were stirred in 100 mL DCE overnight at 65° C. The reaction was cooled and quenched with 10 mL water. The resultant precipitate was filtered and washed with a small amount of DCE giving 1.06 g of the sub-titled compound. The reaction was cooled quenched with 10 mL water The resultant precipitate was filtered washed with a small amount of DCE giving 1.06 g of the sub-titled compound
Source ID: ord-7c5e951ea48447a3bd7b0672c648a2e7Conditions: temp:65.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 5-Chloro-2-methylindole (0.74 g, 2.26 mmol) and 1,4-dichloro-phthalazine (0.45 g, 2.26 mmol) were treated with 30 mL of 1,2-dichloroethane and 3.2 mmol of AlCl3 (427 mg). The resulting suspension was heated to 65° C. overnight. The reaction was cooled and quenched with 3 mL water. The resultant precipitate was filtered and dried under vacuum to give 0.65 g of the sub-title compound. MS: ESI (negative): 326, 328 (M−H). The reaction was cooled quenched with 3 mL water The resultant precipitate was filtered dried under vacuum
Source ID: ord-6599291c2ae44f3da0ff32935552d507PubChem References
These sources are listed in the compound's public database record.
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