5-acetamidopentanoic acid

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: The procedure is as in Example 24, but starting with 5-acetamidopentanoic acid (5 g) in dimethylformamide (66 cc), 3-chloro-2-(7-chloro-1,8-naphthyridin-2-yl)-1-isoindolinone (6.6 g) and 1,8-diazabicyclo[5.4.0]undec-7-ene (4.7 cc). After recrystallization in acetonitrile, 2-(7-chloro-1,8-naphthyridin-2-yl)-3-oxo-1-isoindolinyl 5-acetamidopentanoate (3.3 g), m.p. 185° C., is obtained. After recrystallization in acetonitrile

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: The procedure is as in Example 24, but starting with 5-acetamidopentanoic acid (5 g) in dimethylformamide (66 cc), 3-chloro-2-(7-chloro-1,8-naphthyridin-2-yl)-1-isoindolinone (6.6 g) and 1,8-diazabicyclo[5.4.0]undec-7-ene (4.7 cc). After recrystallization in acetonitrile, 2-(7-chloro-1,8-naphthyridin-2-yl)-3-oxo-1-isoindolinyl 5-acetamidopentanoate (3.3 g), m.p. 185° C., is obtained. After recrystallization in acetonitrile

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: The procedure is as in Example 24, but starting with 5-acetamidopentanoic acid (5 g) in dimethylformamide (66 cc), 3-chloro-2-(7-chloro-1,8-naphthyridin-2-yl)-1-isoindolinone (6.6 g) and 1,8-diazabicyclo[5.4.0]undec-7-ene (4.7 cc). After recrystallization in acetonitrile, 2-(7-chloro-1,8-naphthyridin-2-yl)-3-oxo-1-isoindolinyl 5-acetamidopentanoate (3.3 g), m.p. 185° C., is obtained. After recrystallization in acetonitrile