No renderable structure data available
CC(C)(C)C(=O)OC1CC(=O)C1Chemical Intermediate
Structures, identifiers and computed properties have been matched to the database record by CAS.
| Intermediates | (3-oxocyclobutyl) 2,2-dimethylpropanoate |
|---|---|
| IUPAC Name | — |
| CAS Number | 1071194-23-4 |
| Database ID | 53396992 |
| Molecular Formula | — |
| Molecular Weight | — |
Product Information
(3-oxocyclobutyl) 2,2-dimethylpropanoate (CAS 1071194-23-4) product identity, structure identifiers and related reaction data for chemical intermediate research and sourcing review.
Potential Applications
For professional research and industrial use only
Database ID 53396992
Safety Notice
For professional research and industrial use only. Review the supplier safety data sheet before handling.
Synthesis data
12 reactions · 12 references
Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-1b66cc15fe464a05b73de112368f0912Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To a stirred solution of 3-oxocyclobutyl pivalate (15.1 g, 88.7 mmol) in ethanol (100 ml) at 0° C. was added sodium borohydride (4.69 ml, 133 mmol) in several portions. The reaction was stirred for 30 min, slowly quenched with 10% aqueous HCl and concentrated to remove ethanol. The solution was taken up with more 10% HCl, extracted with DCM (3×), washed with brine, dried over MgSO4 and concentrated to give the title compound as a light yellow oil. slowly quenched with 10% aqueous HCl concentrated to remove ethanol extracted with DCM (3×) washed with brine dried over MgSO4 concentrated
Source ID: ord-c8e3a9220eda47d988c3014f778eab0eConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To a stirred suspension of zinc dust (103 g, 1568 mmol) in HOAc (200 ml) was added a solution of 2,2-dichloro-3-oxocyclobutyl pivalate (75 g, 314 mmol) in HOAc (400 ml) dropwise in an ice bath. The reaction mixture was stirred for 1 h, filtered the solid through celite and washed with DCM. The DCM layer was washed with H2O, NaHCO3, brine, dried over MgSO4, filtered and concentrated. The crude material was purified by ISCO (10% EtOAc/Hexanes) to give the title compound as a light yellow oil. filtered the solid through celite washed with DCM The DCM layer was washed with H2O, NaHCO3, brine dried over MgSO4 filtered concentrated The crude material was purified by ISCO (10% EtOAc/Hexanes)
Source ID: ord-0b2e31a489e347f68e0074489dd476faConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To a stirred solution of 3-oxocyclobutyl pivalate (15.1 g, 88.7 mmol) in ethanol (100 ml) at 0° C. was added sodium borohydride (4.69 ml, 133 mmol) in several portions. The reaction was stirred for 30 min, slowly quenched with 10% aqueous HCl and concentrated to remove ethanol. The solution was taken up with more 10% HCl, extracted with DCM (3×), washed with brine, dried over MgSO4 and concentrated to give the title compound as a light yellow oil. slowly quenched with 10% aqueous HCl concentrated to remove ethanol extracted with DCM (3×) washed with brine dried over MgSO4 concentrated
Source ID: ord-eb16f1145739487d9699aaef36c1fd10Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To a stirred suspension of zinc dust (103 g, 1568 mmol) in HOAc (200 ml) was added a solution of 2,2-dichloro-3-oxocyclobutyl pivalate (75 g, 314 mmol) in HOAc (400 ml) dropwise in an ice bath. The reaction mixture was stirred for 1 h, filtered the solid through celite and washed with DCM. The DCM layer was washed with H2O, NaHCO3, brine, dried over MgSO4, filtered and concentrated. The crude material was purified by ISCO (10% EtOAc/Hexanes) to give the title compound as a light yellow oil. filtered the solid through celite washed with DCM The DCM layer was washed with H2O, NaHCO3, brine dried over MgSO4 filtered concentrated The crude material was purified by ISCO (10% EtOAc/Hexanes)
Source ID: ord-033e3c76d0f245f8b8d8069e7fa725d6Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To a stirred solution of 3-oxocyclobutyl pivalate (15.1 g, 88.7 mmol) in ethanol (100 ml) at 0° C. was added sodium borohydride (4.69 ml, 133 mmol) in several portions. The reaction was stirred for 30 min, slowly quenched with 10% aqueous HCl and concentrated to remove ethanol. The solution was taken up with more 10% HCl, extracted with DCM (3×), washed with brine, dried over MgSO4 and concentrated to give the title compound as a light yellow oil. slowly quenched with 10% aqueous HCl concentrated to remove ethanol extracted with DCM (3×) washed with brine dried over MgSO4 concentrated
Source ID: ord-20e779befb2f4ce69df5e797cbcd9afbConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To a stirred solution of 3-oxocyclobutyl pivalate (15.1 g, 88.7 mmol) in ethanol (100 ml) at 0° C. was added sodium borohydride (4.69 ml, 133 mmol) in several portions. The reaction was stirred for 30 min, slowly quenched with 10% aqueous HCl and concentrated to remove ethanol. The solution was taken up with more 10% HCl, extracted with DCM (3×), washed with brine, dried over MgSO4 and concentrated to give the title compound as a light yellow oil. slowly quenched with 10% aqueous HCl concentrated to remove ethanol extracted with DCM (3×) washed with brine dried over MgSO4 concentrated
Source ID: ord-20e779befb2f4ce69df5e797cbcd9afbConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To a stirred suspension of zinc dust (103 g, 1568 mmol) in HOAc (200 ml) was added a solution of 2,2-dichloro-3-oxocyclobutyl pivalate (75 g, 314 mmol) in HOAc (400 ml) dropwise in an ice bath. The reaction mixture was stirred for 1 h, filtered the solid through celite and washed with DCM. The DCM layer was washed with H2O, NaHCO3, brine, dried over MgSO4, filtered and concentrated. The crude material was purified by ISCO (10% EtOAc/Hexanes) to give the title compound as a light yellow oil. filtered the solid through celite washed with DCM The DCM layer was washed with H2O, NaHCO3, brine dried over MgSO4 filtered concentrated The crude material was purified by ISCO (10% EtOAc/Hexanes)
Source ID: ord-e1b750b305d849ea930c984b1e95ea7eConditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-1b66cc15fe464a05b73de112368f0912Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To a stirred solution of 3-oxocyclobutyl pivalate (15.1 g, 88.7 mmol) in ethanol (100 ml) at 0° C. was added sodium borohydride (4.69 ml, 133 mmol) in several portions. The reaction was stirred for 30 min, slowly quenched with 10% aqueous HCl and concentrated to remove ethanol. The solution was taken up with more 10% HCl, extracted with DCM (3×), washed with brine, dried over MgSO4 and concentrated to give the title compound as a light yellow oil. slowly quenched with 10% aqueous HCl concentrated to remove ethanol extracted with DCM (3×) washed with brine dried over MgSO4 concentrated
Source ID: ord-0ae921b79cb342d9be17eff0cdf135e9Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To a stirred suspension of zinc dust (103 g, 1568 mmol) in HOAc (200 ml) was added a solution of 2,2-dichloro-3-oxocyclobutyl pivalate (75 g, 314 mmol) in HOAc (400 ml) dropwise in an ice bath. The reaction mixture was stirred for 1 h, filtered the solid through celite and washed with DCM. The DCM layer was washed with H2O, NaHCO3, brine, dried over MgSO4, filtered and concentrated. The crude material was purified by ISCO (10% EtOAc/Hexanes) to give the title compound as a light yellow oil. filtered the solid through celite washed with DCM The DCM layer was washed with H2O, NaHCO3, brine dried over MgSO4 filtered concentrated The crude material was purified by ISCO (10% EtOAc/Hexanes)
Source ID: ord-a1c0857b421541e49c96b880bb59740cConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To a stirred solution of 3-oxocyclobutyl pivalate (15.1 g, 88.7 mmol) in ethanol (100 ml) at 0° C. was added sodium borohydride (4.69 ml, 133 mmol) in several portions. The reaction was stirred for 30 min, slowly quenched with 10% aqueous HCl and concentrated to remove ethanol. The solution was taken up with more 10% HCl, extracted with DCM (3×), washed with brine, dried over MgSO4 and concentrated to give the title compound as a light yellow oil. slowly quenched with 10% aqueous HCl concentrated to remove ethanol extracted with DCM (3×) washed with brine dried over MgSO4 concentrated
Source ID: ord-52397bddaa924ffab0e99960c05b2439PubChem References
These sources are listed in the compound's public database record.
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