methyl (2R)-2-amino-3-[[(2R)-2-amino-3-methoxy-3-oxopropyl]disulfanyl]propanoate

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: 5 g of polymer (2) and 5.3 g of cystine dimethyl ester hydrochloride are dissolved in 100 ml of water. 6 g of N-dimethylaminopropyl-N'-ethylcarbodiimide (EDC) are then dissolved in 5 ml of water and immediately added to the reaction mixture. The mixture immediately turns dark red and, after a few seconds, a pink precipitate is then formed. The reaction is stopped after 3 hours and 200 ml of water are added. The precipitate is recovered by filtration, washed several times with water and then oven-dried under vacuum. immediately added to the reaction mixture The mixture immediately turns dark red and, after a few seconds a pink precipitate is then formed The precipitate is recovered by filtration washed several times with water oven-dried under vacuum