No renderable structure data available
CC1=C(C=CC(=C1)N)NC(=O)C2=CC=CC=C2Chemical Intermediate
Structures, identifiers and computed properties have been matched to the database record by CAS.
| Intermediates | N-(4-amino-2-methylphenyl)benzamide |
|---|---|
| IUPAC Name | — |
| CAS Number | 104478-99-1 |
| Database ID | 3245571 |
| Molecular Formula | — |
| Molecular Weight | — |
Product Information
N-(4-amino-2-methylphenyl)benzamide (CAS 104478-99-1) product identity, structure identifiers and related reaction data for chemical intermediate research and sourcing review.
Potential Applications
For professional research and industrial use only
Database ID 3245571
Safety Notice
For professional research and industrial use only. Review the supplier safety data sheet before handling.
Synthesis data
12 reactions · 12 references
Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-f7b7e6a1757447a0926d2ce859619bc1Conditions: temp:70.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A suspension of N-(2-methyl-4-nitrophenyl)benzamide (0.256 g, 1.0 mmol) and tin(II) chloride dihydrate (0.89 g, 3.96 mmol) in ethyl acetate (6 mL) was heated at 70° C. for 19 hr. The reaction mixture was then chilled, poured onto 50 mL ice, basified with 5% NaHCO3 (20 mL), extracted into EtOAc, washed with brine, dried and concentrated in vacuo to give N-(4-amino-2-methylphenyl)-benzamide (0.22 g, 97%). ES-MS (M+H)+=227, (M+Na)+=249. The reaction mixture was then chilled extracted into EtOAc washed with brine dried concentrated in vacuo
Source ID: ord-ef776f3c4c6d4e7e8b9ba48d9f61fbe6Conditions: temp:70.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A suspension of N-(2-methyl-4-nitrophenyl)benzamide (0.256 g, 1.0 mmol) and tin (II) chloride dihydrate (0.89 g, 3.96 mmol) in ethyl acetate (6 mL) was heated at 70° C. for 19 hr. The reaction mixture was then chilled, poured onto 50 mL ice, basified with 5% NaHCO3 (20 mL), extracted into EtOAc, washed with brine, dried and concentrated in vacuo to give N-(4-amino-2-methylphenyl)-benzamide (0.22 g, 97%). ES-MS (M+H)+=227, (M+Na)+=249. The reaction mixture was then chilled extracted into EtOAc washed with brine dried concentrated in vacuo
Source ID: ord-5b5df69fcada408b9ab6ab3cdcb4afe3Conditions: temp:70.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A suspension of N-(2-methyl-4-nitrophenyl)benzamide (0.256 g, 1.0 mmol) and tin(II) chloride dihydrate (0.89 g, 3.96 mmol) in ethyl acetate (6 mL) was heated at 70° C. for 19 hr. The reaction mixture was then chilled, poured onto 50 mL ice, basified with 5% NaHCO3 (20 mL), extracted into EtOAc, washed with brine, dried and concentrated in vacuo to give N-(4-amino-2-methylphenyl)-benzamide (0.22 g, 97%). ES-MS (M+H)+=227, (M+Na)+=249. The reaction mixture was then chilled extracted into EtOAc washed with brine dried concentrated in vacuo
Source ID: ord-fad3ad333e5743fea00ebe425e67a7c6Conditions: temp:70.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A suspension of N-(2-methyl-4-nitrophenyl)benzamide (0.256 g, 1.0 mmol) and tin(II) chloride dihydrate (0.89 g, 3.96 mmol) in ethyl acetate (6 mL) was heated at 70° C. for 19 hr. The reaction mixture was then chilled, poured onto 50 mL ice, basified with 5% NaHCO3 (20 mL), extracted into EtOAc, washed with brine, dried and concentrated in vacuo to give N-(4-amino-2-methylphenyl)-benzamide (0.22 g, 97%). ES-MS (M+H)+=227, (M+Na)+=249. The reaction mixture was then chilled extracted into EtOAc washed with brine dried concentrated in vacuo
Source ID: ord-433482186fb34f1bbd2aba6159511ec9Conditions: temp:70.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A suspension of N-(2-methyl-4-nitrophenyl)benzamide (0.256 g, 1.0 mmol) and tin(II) chloride dihydrate (0.89 g, 3.96 mmol) in ethyl acetate (6 mL) was heated at 70° C. for 19 hr. The reaction mixture was then chilled, poured onto 50 mL ice, basified with 5% NaHCO3 (20 mL), extracted into EtOAc, washed with brine, dried and concentrated in vacuo to give N-(4-amino-2-methylphenyl)-benzamide (0.22 g, 97%). ES-MS (M+H)+=227, (M+Na)+=249. The reaction mixture was then chilled extracted into EtOAc washed with brine dried concentrated in vacuo
Source ID: ord-433482186fb34f1bbd2aba6159511ec9Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-f7b7e6a1757447a0926d2ce859619bc1Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A mixture of N-benzoyl 2-methyl-4-nitroaniline (2.93 g, 11.4 mmol) and tin (II) chloride (12.9 g, 57.2 mmol) were heated in ethyl acetate (100 ml) at reflux for 2 hours under an inert atmosphere. The reaction was allowed to cool to ambient temperature and concentrated aqueous ammonia (20 ml) was added. The reaction was filtered, the solid material was washed with ethyl acetate (3×30 ml) and then the combined organic layers were evaporated in vacuo. Drying of the resultant solid in vacuo, yielded N-benzoyl 2-methyl-4-aminoaniline (1.03 g, 40% yield) as a white crystalline solid: at reflux for 2 hours under an inert atmosphere The reaction was filtered the solid material was washed with ethyl acetate (3×30 ml) the combined organic layers were evaporated in vacuo Drying of the resultant solid in vacuo
Source ID: ord-90a21e47eec34958ad2883162a8952b0Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A mixture of N-benzoyl 2-methyl-4-nitroaniline (2.93 g, 11.4 mmol) and tin (II) chloride (12.9 g, 57.2 mmol) were heated in ethyl acetate (100 ml) at reflux for 2 hours under an inert atmosphere. The reaction was allowed to cool to ambient temperature and concentrated aqueous ammonia (20 ml) was added. The reaction was filtered, the solid material was washed with ethyl acetate (3×30 ml) and then the combined organic layers were evaporated in vacuo. Drying of the resultant solid in vacuo, yielded N-benzoyl 2-methyl-4-aminoaniline (1.03 g, 40% yield) as a white crystalline solid: at reflux for 2 hours under an inert atmosphere The reaction was filtered the solid material was washed with ethyl acetate (3×30 ml) the combined organic layers were evaporated in vacuo Drying of the resultant solid in vacuo
Source ID: ord-90a21e47eec34958ad2883162a8952b0Conditions: temp:70.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A suspension of N-(2-methyl-4-nitrophenyl)benzamide (0.256 g, 1.0 mmol) and tin(II) chloride dihydrate (0.89 g, 3.96 mmol) in ethyl acetate (6 mL) was heated at 70° C. for 19 hr. The reaction mixture was then chilled, poured onto 50 mL ice, basified with 5% NaHCO3 (20 mL), extracted into EtOAc, washed with brine, dried and concentrated in vacuo to give N-(4-amino-2-methylphenyl)-benzamide (0.22 g, 97%). ES-MS (M+H)+=227, (M+Na)+=249. The reaction mixture was then chilled extracted into EtOAc washed with brine dried concentrated in vacuo
Source ID: ord-f8bd3ce2daa5402cb4801c138279f56bConditions: temp:70.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A suspension of N-(2-methyl-4-nitrophenyl)benzamide (0.256 g, 1.0 mmol) and tin(II) chloride dihydrate (0.89 g, 3.96 mmol) in ethyl acetate (6 mL) was heated at 70° C. for 19 hr. The reaction mixture was then chilled, poured onto 50 mL ice, basified with 5% NaHCO3 (20 mL), extracted into EtOAc, washed with brine, dried and concentrated in vacuo to give N-(4-amino-2-methylphenyl)-benzamide (0.22 g, 97%). ES-MS (M+H)+=227, (M+Na)+=249. The reaction mixture was then chilled extracted into EtOAc washed with brine dried concentrated in vacuo
Source ID: ord-79298a4b722143d581c73f2d0ae297f5Conditions: temp:70.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A suspension of N-(2-methyl-4-nitrophenyl)benzamide (0.256 g, 1.0 mmol) and tin(II) chloride dihydrate (0.89 g, 3.96 mmol) in ethyl acetate (6 mL) was heated at 70° C. for 19 hr. The reaction mixture was then chilled, poured onto 50 mL ice, basified with 5% NaHCO3 (20 mL), extracted into EtOAc, washed with brine, dried and concentrated in vacuo to give N-(4-amino-2-methylphenyl)-benzamide (0.22 g, 97%). ES-MS (M+H)+=227, (M+Na)+=249. The reaction mixture was then chilled extracted into EtOAc washed with brine dried concentrated in vacuo
Source ID: ord-ef776f3c4c6d4e7e8b9ba48d9f61fbe6PubChem References
These sources are listed in the compound's public database record.
Related Products
12 related records
CAS 328546-66-3
CAS 556-08-1
CAS 6876-66-0
CAS 59755-25-8
CAS 6957-81-9
CAS 316138-75-7
CAS 366-63-2
CAS 53205-69-9
CAS 14359-73-0
CAS 41378-23-8
CAS 890707-29-6
CAS 32212-38-7
Request a Quote
Send the required specification, quantity, destination and intended use. The CATO team will review availability and respond.