3-bromopropyl trifluoromethanesulfonate

Conditions: temp:80.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: To a mixture of (4-methoxy-cyclohexyl)-methanol (1.25 g, 8.7 mmol) and trifluoromethanesulfonic acid 3-bromo-propyl ester (2.58 g, 9.55 mmol) in nitromethane (15 ml) was added 2,6-di-tert-butylpyridine (1.83 ml, 9.55 mmol). The reaction mixture was heated at 80° C. for 18 hours. The mixture was concentrated in vacuo and the residue purified by flash column chromatography on silica eluting with 20% ethyl acetate in hexane to give the title compound as a yellow oil (1.4 g, 61%). The mixture was concentrated in vacuo the residue purified by flash column chromatography on silica eluting with 20% ethyl acetate in hexane

Conditions: temp:80.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: To a mixture of (4-methoxy-cyclohexyl)-methanol (1.25 g, 8.7 mmol) and trifluoromethanesulfonic acid 3-bromo-propyl ester (2.58 g, 9.55 mmol) in nitromethane (15 ml) was added 2,6-di-tert-butylpyridine (1.83 ml, 9.55 mmol). The reaction mixture was heated at 80° C. for 18 hours. The mixture was concentrated in vacuo and the residue purified by flash column chromatography on silica eluting with 20% ethyl acetate in hexane to give the title compound as a yellow oil (1.4 g, 61%). The mixture was concentrated in vacuo the residue purified by flash column chromatography on silica eluting with 20% ethyl acetate in hexane

Conditions: temp:80.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: To a mixture of (4-methoxy-cyclohexyl)-methanol (1.25 g, 8.7 mmol) and trifluoromethanesulfonic acid 3-bromo-propyl ester (2.58 g, 9.55 mmol) in nitromethane (15 ml) was added 2,6-di-tert-butylpyridine (1.83 ml, 9.55 mmol). The reaction mixture was heated at 80° C. for 18 hours. The mixture was concentrated in vacuo and the residue purified by flash column chromatography on silica eluting with 20% ethyl acetate in hexane to give the title compound as a yellow oil (1.4 g, 61%). The mixture was concentrated in vacuo the residue purified by flash column chromatography on silica eluting with 20% ethyl acetate in hexane