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C1C(NCS1)C(=O)NChemical Intermediate
Structures, identifiers and computed properties have been matched to the database record by CAS.
| Intermediates | 1,3-thiazolidine-4-carboxamide |
|---|---|
| IUPAC Name | — |
| CAS Number | 103749-87-7 |
| Database ID | 9964101 |
| Molecular Formula | — |
| Molecular Weight | — |
Product Information
1,3-thiazolidine-4-carboxamide (CAS 103749-87-7) product identity, structure identifiers and related reaction data for chemical intermediate research and sourcing review.
Potential Applications
For professional research and industrial use only
Database ID 9964101
Safety Notice
For professional research and industrial use only. Review the supplier safety data sheet before handling.
Synthesis data
12 reactions · 12 references
Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-eb81ec449e0a40afbb36e255edf11c06Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-07b121c64e5847ddb030a5ba9c79e208Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-b38bded8771b4cdcb77f95a97a5da13bConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: In analogy to the procedure described in Example 47 b), 6-cyclopropylmethoxy-5-(3,3-difluoro-azetidin-1-yl)-pyridine-2-carboxylic acid (Example 1 b)) was reacted with and 4-thiazolidinecarboxamide (CAN 103749-87-7) in the presence of TBTU and DIEA to obtain the title compound as white solid; MS (EI): m/e=399.5 [MH+].
Source ID: ord-40bd7372dfd94feb8b5d259ea4fc9ebbConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: In analogy to the procedure described in Example 47 b), 6-cyclopropylmethoxy-5-(3,3-difluoro-azetidin-1-yl)-pyridine-2-carboxylic acid (Example 1 b)) was reacted with and 4-thiazolidinecarboxamide (CAN 103749-87-7) in the presence of TBTU and DIEA to obtain the title compound as white solid; MS (EI): m/e=399.5 [MH+].
Source ID: ord-40bd7372dfd94feb8b5d259ea4fc9ebbConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: In analogy to the procedure described in Example 47 b), 6-cyclopropylmethoxy-5-(3,3-difluoro-azetidin-1-yl)-pyridine-2-carboxylic acid (Example 1 b)) was reacted with and 4-thiazolidinecarboxamide (CAN 103749-87-7) in the presence of TBTU and DIEA. The mixture of enantiomers was separated by chiral HPLC (Reprosil Chiral NR). The (−) enantiomer was isolated as white solid; MS (EI): m/e=399.4 [MH+]; αD20 (DMSO)=−547.6°. The mixture of enantiomers was separated by chiral HPLC (Reprosil Chiral NR) The (−) enantiomer was isolated as white solid
Source ID: ord-0ac6b95bcb5641d3a4f1b1fd101c73b1Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: In analogy to the procedure described in Example 47 b), 6-cyclopropylmethoxy-5-(3,3-difluoro-azetidin-1-yl)-pyridine-2-carboxylic acid (Example 1 b)) was reacted with and 4-thiazolidinecarboxamide (CAN 103749-87-7) in the presence of TBTU and DIEA. The mixture of enantiomers was separated by chiral HPLC (Reprosil Chiral NR). The (−) enantiomer was isolated as white solid; MS (EI): m/e=399.4 [MH+]; αD20 (DMSO)=−547.6°. The mixture of enantiomers was separated by chiral HPLC (Reprosil Chiral NR) The (−) enantiomer was isolated as white solid
Source ID: ord-0ac6b95bcb5641d3a4f1b1fd101c73b1Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: The title compound was synthesized in analogy to Example 47 b, using 5-cyclopropyl-6-cyclopropylmethoxy-pyridine-2-carboxylic acid (Example 3 c, 100 mg, 429 μmol) and 4-thiazolidinecarboxamide (CAN 103749-87-7, 62.3 mg, 472 μmol) as starting materials and isolated (114 mg, 77%) as white solid; LC-MS (UV peak area, ESI) 100%, 348.1377 [MH+]. isolated (114 mg, 77%) as white solid
Source ID: ord-b6df4d90c15b4b1b85de68a7779c03d5Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: The title compound was synthesized in analogy to Example 47 b, using 5-cyclopropyl-6-cyclopropylmethoxy-pyridine-2-carboxylic acid (Example 3 c, 100 mg, 429 μmol) and 4-thiazolidinecarboxamide (CAN 103749-87-7, 62.3 mg, 472 μmol) as starting materials and isolated (114 mg, 77%) as white solid; LC-MS (UV peak area, ESI) 100%, 348.1377 [MH+]. isolated (114 mg, 77%) as white solid
Source ID: ord-b6df4d90c15b4b1b85de68a7779c03d5Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-eb81ec449e0a40afbb36e255edf11c06Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-07b121c64e5847ddb030a5ba9c79e208Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-b38bded8771b4cdcb77f95a97a5da13bPubChem References
These sources are listed in the compound's public database record.
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